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Synergistic relaxing effect of the paracetamol and pyrilamine combination in isolated human myometrium.

Eur J Obstet Gynecol Reprod Biol

July 2011

Área Académica de Medicina del Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, and Hospital General de los SSH, Pachuca, Hidalgo, Mexico.

Objective: To evaluate the interaction type of the human uterine relaxant effect of the paracetamol-pyrilamine combination (PPC) in vitro.

Study Design: Uterine strips were contracted with KCl (60 mM) and treated with vehicle or increasing concentrations of paracetamol (100-3200 μM), pyrilamine (3.2-100 μM) or the PPC.

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