Advances in Receptor-Targeted Radiolabeled Peptides for Melanoma Imaging and Therapy.

Melanocortin-1 receptor (MC1R) and very late antigen-4 (VLA-4, integrin αβ) are 2 attractive molecular targets for developing peptide radiopharmaceuticals for melanoma imaging and therapy. MC1R- and VLA-4-targeting peptides and peptide-conjugated Cornell prime dots (C' dots) can serve as delivery vehicles to target both diagnostic and therapeutic radionuclides to melanoma cells for imaging and therapy. This review highlights the advances of MC1R- and VLA-4-targeted radiolabeled peptides and peptide-conjugated C' dots for melanoma imaging and therapy.

Selenium exposure and depressive symptoms: the Coronary Artery Risk Development in Young Adults Trace Element Study.

Selenium is an essential trace element important to neurotransmission, but toxic at high levels. Some studies suggest beneficial effects on mood. We assessed the association of selenium exposure with presence of depressive symptoms.