6 results match your criteria: "and German Centre for Diabetes Research[Affiliation]"
Comorbidity of inflammatory bowel disease in children and adolescents with type 1 diabetes.
Acta Paediatr
April 2021
Institute of Epidemiology and Medical Biometry, ZIBMT, University of Ulm, and German Centre for Diabetes Research, DZD, Munich-Neuherberg, Germany.
Aim: To determine the prevalence of inflammatory bowel disease (IBD) in patients with type 1 diabetes (T1D) and to characterise patients with both diseases.
Methods: Data of 65.147 patients with T1D ≤18 years of 379 centres in Germany and Austria participating in the DPV initiative were analysed.
Lung Based Engineered Micro-Pancreas Sustains Human Beta Cell Survival and Functionality.
Horm Metab Res
December 2019
Betalin Therapeutics LTD, Jerusalem Bio-Park, Jerusalem, Israel.
Article Synopsis
- The global rise in diabetes cases is linked to β-cell dysfunction, which affects insulin production in both type 1 and type 2 diabetes.
- Traditional drug evaluations in the pharmaceutical industry rely on cell lines and rodent models, which do not accurately replicate human islet function, limiting the predictive power for new diabetes treatments.
- The innovative Engineered Micro-Pancreas, utilizing a decellularized lung-derived scaffold and human islets, shows promising viability and insulin secretion comparable to human islets, paving the way for more effective drug discovery methods.
3D Bioprinting of Functional Islets of Langerhans in an Alginate/Methylcellulose Hydrogel Blend.
Adv Healthc Mater
April 2019
Centre for Translational Bone, Joint and Soft Tissue Research, University Hospital Carl Gustav Carus and Faculty of Medicine of Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Germany.
Transplantation of pancreatic islets is a promising strategy to alleviate the unstable blood-glucose control that some patients with diabetes type 1 exhibit and has seen many advances over the years. Protection of transplanted islets from the immune system can be accomplished by encapsulation within a hydrogel, the most investigated of which is alginate. In this study, islet encapsulation is combined with 3D extrusion bioprinting, an additive manufacturing method which enables the fabrication of 3D structures with a precise geometry to produce macroporous hydrogel constructs with embedded islets.
View Article and Find Full Text PDFImpact of quality of life (QoL) on glycemic control (HbA1c) among adolescents and emerging adults with long-duration type 1 diabetes: A prospective cohort-study.
Pediatr Diabetes
December 2017
Institute for Biometrics and Epidemiology, German Diabetes Centre, Leibniz Centre for Diabetes Research, German Centre for Diabetes Research (DZD), Düsseldorf, Germany.
Objective: To evaluate the impact of self-reported chronic-generic and condition-specific quality of life (QoL) on glycemic control among adolescents and emerging adults with long-duration type 1 diabetes (T1D) in a longitudinal design.
Methods: The database used was a nationwide cohort study of patients with ≥10 years T1D duration at baseline in Germany. The baseline questionnaire survey was conducted in 2009-2010, the follow-up survey in 2012-2013; additional clinical data of routine care procedures were linked.
Sex Hormones and Sleep in Men and Women From the General Population: A Cross-Sectional Observational Study.
J Clin Endocrinol Metab
November 2016
Institute of Clinical Chemistry and Laboratory Medicine (H.K., H.W., M.N., R.H.), Departments of Internal Medicine B (R.E., A.O., B.S.) and Cardiology (S.G., M.D.), and Institute for Community Medicine (H.V.), University Medicine Greifswald, D-17475 Greifswald, Germany; Interdisciplinary Sleep Center (I.F., T.P.), Charité, University Medicine, 10117 Berlin, Germany; German Centre for Cardiovascular Research (S.G., H.V., M.D., M.N.) and German Centre for Diabetes Research (H.V.), partner site Greifswald, 13092 Greifswald, Germany; and Faculty of Applied Public Health (R.H.), European University of Applied Sciences, 18051 Rostock, Germany.
Context And Objectives: Associations between sex hormones and sleep habits originate mainly from small and selected patient-based samples. We examined data from a population-based sample with various sleep characteristics and the major part of sex hormones measured by mass spectrometry.
Design, Setting, And Participants: We used data from 204 men and 213 women of the cross-sectional Study of Health in Pomerania-TREND.
Incretin actions and consequences of incretin-based therapies: lessons from complementary animal models.
J Pathol
January 2016
Gene Centre, Centre for Innovative Medical Models (CiMM) and German Centre for Diabetes Research (DZD), Ludwig-Maximilians-Universität München, Germany.
The two incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP1), were discovered 45 and 30 years ago. Initially, only their insulinotropic effect on pancreatic β cells was known. Over the years, physiological and pharmacological effects of GIP and GLP1 in numerous extrapancreatic tissues were discovered which partially overlap, but may also be specific for GIP or GLP1 in certain target tissues.
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