10 results match your criteria: "and George Washington School of Medicine and Health Sciences[Affiliation]"
Proteomic profiling of the local and systemic immune response to pediatric respiratory viral infections.
mSystems
January 2025
Department of Pediatrics, Critical Care, University of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock, Arkansas, USA.
Article Synopsis
- Viral lower respiratory tract infection (vLRTI) significantly impacts global child health, prompting research into the host immune responses using proteomics for better understanding and diagnosis.
- The study analyzed 1,305 proteins from tracheal aspirate and plasma of 62 critically ill children, finding 200 differentially expressed proteins that reveal key immune responses, with a robust nine-protein TA classifier showing high diagnostic accuracy (AUC of 0.96).
- It also highlighted the limited correlation between tracheal aspirate and plasma proteins and examined how viral load and bacterial co-infections influence immune signaling pathways.
Proteomic profiling of the local and systemic immune response to pediatric respiratory viral infections.
bioRxiv
October 2024
Department of Pediatrics, Critical Care, University of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock, AR.
Article Synopsis
- Viral lower respiratory tract infection (vLRTI) is a major cause of pediatric hospitalization and mortality globally, yet the immune responses involved are not well understood.
- A study analyzed over 1,300 proteins in tracheal aspirate and plasma from critically ill children, identifying significant protein changes linked to vLRTI and developing a diagnostic tool with high accuracy.
- Key findings included increased interferon and T cell responses in the lower airway, distinct protein profiles in plasma, and novel protein biomarkers that could enhance diagnostic approaches for severe vLRTI.
A randomized, controlled trial of an innovative, multimedia instructional program for acquiring auditory skill in identifying pediatric heart murmurs.
Front Pediatr
January 2024
Division of Biostatistics, Children's National Hospital and George Washington School of Medicine and Health Sciences, Washington, DC, United States.
Objective: To create a brief, acceptable, innovative method for self-paced learning to enhance recognition of pediatric heart murmurs by medical students, and to demonstrate this method's effectiveness in a randomized, controlled trial.
Materials And Methods: A curriculum of six 10-min online learning modules was designed to enable deliberate practice of pediatric cardiac auscultation, using recordings of patients' heart murmurs. Principles of andragogy and multimedia learning were applied to optimize acquisition of this skill.
Brentuximab Vedotin with Chemotherapy in Pediatric High-Risk Hodgkin's Lymphoma.
N Engl J Med
November 2022
From the Department of Pediatrics, Emory University School of Medicine (S.M.C., F.G.K.), and Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta (S.M.C., F.G.K.) - both in Atlanta; the Department of Biostatistics, Children's Oncology Group, Statistics and Data Center, University of Florida, Gainesville (Q.P., Y.W.), and the Department of Radiation Oncology, Mayo Clinic Florida, Jacksonville (B.S.H.); the Institute for Clinical Research and Health Policy Studies and Tufts Cancer Center, Tufts Medical Center, Boston (S.K.P.); the Department of Radiation Oncology, Princess Margaret Cancer Centre and University of Toronto (D.H.), and the Division of Hematology-Oncology, Hospital for Sick Children and University of Toronto (A.P.), Toronto, and the Department of Radiation Oncology, Centre Hospitalier de l'Université de Montréal, Montreal (A.-M.C.) - all in Canada; Imaging and Radiation Oncology Core Rhode Island, Lincoln (K.M.); the Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston (T.H.); the Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison (S.C.); the Department of Pediatrics, Children's National Hospital, and George Washington School of Medicine and Health Sciences, Washington, DC (H.D.); the Department of Pediatrics, University of Chicago Pritzker School of Medicine, Comer Children's Hospital, Chicago (T.O.H.); and the Department of Pediatrics, Roswell Park Comprehensive Cancer Center, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY (K.M.K.).
Background: In adults with advanced-stage Hodgkin's lymphoma, the CD30-directed antibody-drug conjugate brentuximab vedotin combined with multiagent chemotherapy has been shown to have greater efficacy, but also more toxic effects, than chemotherapy alone. The efficacy of this targeted therapy approach in children and adolescents with Hodgkin's lymphoma is unclear.
Methods: We conducted an open-label, multicenter, randomized, phase 3 trial involving patients 2 to 21 years of age with previously untreated Hodgkin's lymphoma of stage IIB with bulk tumor or stage IIIB, IVA, or IVB.
Temporal airway microbiome changes related to ventilator-associated pneumonia in children.
Eur Respir J
March 2021
Biostatistics and Informatics, University of Colorado, Colorado School of Public Health, Aurora, CO, USA.
We sought to determine whether temporal changes in the lower airway microbiome are associated with ventilator-associated pneumonia (VAP) in children.Using a multicentre prospective study of children aged 31 days to 18 years requiring mechanical ventilation support for >72 h, daily tracheal aspirates were collected and analysed by sequencing of the 16S rRNA gene. VAP was assessed using 2008 Centers for Disease Control and Prevention paediatric criteria.
View Article and Find Full Text PDFAge at Craniosynostosis Surgery and Its Impact on Ophthalmologic Diagnoses: A Single-Center Retrospective Review.
Plast Reconstr Surg
September 2020
Department of Plastic and Oral Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Mass.
Interdisciplinary Communication: Documentation of Advance Care Planning and End-of-Life Care in Adolescents and Young Adults With Cancer.
J Hosp Palliat Nurs
June 2019
Anne Watson, PhD, MSc, BSN, RN, is case manager, Children's National Health System, Washington, DC. Meaghann Weaver, MD, MPH, is attending physician, Children's Hospital and Medical Center Omaha, NE. Shana Jacobs, MD, is attending physician, Children's National Health System, Washington, DC. Maureen E. Lyon, PhD, is research scientist, Division of Adolescent and Young Adult Medicine, Center for Translational Science/Children's Research Institute, and Department of Pediatrics, Children's National Health System; and George Washington School of Medicine and Health Sciences, Washington, DC.
Advance care planning is being increasingly recognized as a component of quality in end-of-life care, but standardized documentation in the electronic health record has not yet been achieved, undermining interdisciplinary communication about care needs and limiting research opportunities.We examined the electronic health records of nine adolescent and young adults with cancer who died after participation in an advance care planning clinical trial (N = 30). In this secondary analysis of this subgroup, disease trajectory and end-of-life information were abstracted from the electronic health record, and treatment preferences from the original study were obtained.
View Article and Find Full Text PDFSpirituality in HIV-infected adolescents and their families: FAmily CEntered (FACE) Advance Care Planning and medication adherence.
J Adolesc Health
June 2011
Children's National Medical Center, Division of Adolescent and Young Adult Medicine, and George Washington School of Medicine and Health Sciences, Washington, District of Columbia 20010-2970, USA.
Purpose: To explore the effect of spirituality and religious beliefs on FAmily CEntered (FACE) Advance Care Planning and medication adherence among human immunodeficiency virus (HIV) positive adolescents and their surrogate decision-makers.
Methods: A sample of HIV-positive adolescents (n = 40) and their surrogates, aged ≥ 21 years, (n = 40), was randomized to an active Healthy Living Control group or the FACE Advance Care Planning intervention, guided by transactional stress and coping theory. Adolescents' spirituality and their belief that HIV is a punishment from God were assessed at baseline and 3 months after the intervention, using the Functional Assessment of Chronic Illness Therapy-Spiritual Well Being Scale, Expanded, Version 4.
Is it safe? Talking to teens with HIV/AIDS about death and dying: a 3-month evaluation of Family Centered Advance Care (FACE) planning - anxiety, depression, quality of life.
HIV AIDS (Auckl)
November 2011
Children's National Medical Center and George Washington School of Medicine and Health Sciences, Washington, District of Columbia.
Purpose: To determine the safety of engaging HIV-positive (HIV+) adolescents in a Family Centered Advance Care (FACE) planning intervention.
Patients And Methods: We conducted a 2-armed, randomized controlled clinical trial in 2 hospital-based outpatient clinics from 2006-2008 with HIV+ adolescents and their surrogates (n = 76). Three 60-90 minutes sessions were conducted weekly.