1 results match your criteria: "and Galicia Sur Health Research Institute and University Hospital Complex of Vigo[Affiliation]"
Central Role of Semaphorin 3B in a Serum-Induced Arthritis Model and Reduced Levels in Patients With Rheumatoid Arthritis.
Arthritis Rheumatol
June 2022
University of Utrecht, Utrecht, The Netherlands, and Galicia Sur Health Research Institute and University Hospital Complex of Vigo, Vigo, Spain.
Objective: Semaphorin 3B (Sema3B) decreases the migratory and invasive capacities of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA) and suppresses expression of matrix metalloproteinases. We undertook this study to examine the role of Sema3B in a mouse model of arthritis and its expression in RA patients.
Methods: Clinical responses, histologic features, and FLS function were examined in wild-type (WT) and Sema3B mice in a K/BxN serum transfer model of arthritis.