1 results match your criteria: "and Fujikoshi Hospital[Affiliation]"
Roles of PDGF receptor-beta in the structure and function of postnatal kidney glomerulus.
Nephrol Dial Transplant
February 2011
Second Department of Internal Medicine, Graduate School of Medicine and Pharmaceutical Sciences for Research, University ofToyama, and Fujikoshi Hospital, 2630, Sugitani, Toyama 930-0194, Japan.
Background: Mesangial cell functions are critically regulated by platelet-derived growth factor receptor (PDGFR)-β signals. In contrast to the well-established role of PDGFR-β in the development of kidney glomerulus, its role in adult kidney glomerulus remains controversial.
Methods: We deleted the PDGFR-β gene postnatally using the Cre-loxP system and analysed the long-term effects of PDGFR-β inhibition on glomerular changes associated with ageing and subtotal nephrectomy.