Non-enzymatic cholesterol biosensor: Electrochemical sensing based on peptide-polylactic acid thin film.

Cholesterol is a fundamental lipid prevalent in eukaryotic cell membranes and circulating in the bloodstream bound to lipoproteins. It serves as a precursor to steroid hormones and is regarded as a biomarker for cardiovascular disease and other metabolic disorders. Numerous cholesterol detection methods predominantly rely on enzymes, which suffer from instability, leading to non-cost-effective biosensors with low sensitivity and poor reusability.

Microencapsulation of hop bioactive compounds by spray drying: Role of inlet temperature and wall material.

This study explores the effect of spray-drying (SD) inlet temperatures (T 120 and 150 °C) and wall material on the chemical and physico-chemical properties of microencapsulated hop extracts (MHE). Hop extract was formulated with maltodextrin (MD) and gum Arabic (GA) used in single or in combination with β-cyclodextrin (βCD). MHE were evaluated for physical properties, bitter acids (BA), total polyphenol content (TPC) and encapsulation efficiency (TPC EE), and antioxidant capacity (AOC).

First Insight into the Neuroprotective and Antibacterial Effects of Phlorotannins Isolated from the Cell Walls of Brown Algae and .

Phaeophyceae (brown algae) essentially contribute to biotopes of cold and temperate seas. Their thalli are rich in biologically active natural products, which are strongly and universally dominated with phlorotannins-polyphenols of complex and diverse structure based on multiple differently arranged phloroglucinol units and well known as strong antioxidants with a broad spectrum of biological activities. In the algal cells, phlorotannins can either accumulate in the cytoplasm or can be secreted into the cell wall (CW).

Epigenetic regulation of DAT gene promoter modulates the risk of externalizing and internalizing behaviors on a normative population: An explorative study.

Accumulating research addressed epigenetic modifications and their role on behavioral phenotypes. We recently proposed to study methylation dynamics of two CpG motifs within the 5'-UTR of dopamine transporter (DAT) gene. Starting from a normative population sample of young adults, we selected three sub-groups based on their prevalent symptoms: subjects were assigned to Internalizing, Externalizing and Low-risk sub-groups according to elevated scores in specific phenotypic scales.

Erratum: Sanz del Olmo, N.; et al. Antioxidant and Antibacterial Properties of Carbosilane Dendrimers Functionalized with Polyphenolic Moieties. 2020, , 698.

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Effect of phenolic compounds-capped AgNPs on growth inhibition of Aspergillus niger.

An exponential increase of scientific works dealing with the use of polyphenol-rich 'natural products' for the synthesis of bioactive AgNPs is in progress. However, a lack of fundamental studies on phytochemical compounds involved, and their role is evident. In this work, a comprehensive study of the antifungal performances of silver nanoparticles (AgNPs) synthesized exclusively with phenolic compounds (PCs) with different structures and different antioxidant capacity is presented.

Corrigendum to "Peripheral Blood Mononuclear Cells as a Laboratory to Study Dementia in the Elderly".

[This corrects the article DOI: 10.1155/2014/169203.].

Antioxidant and Antibacterial Properties of Carbosilane Dendrimers Functionalized with Polyphenolic Moieties.

A new family of polyphenolic carbosilane dendrimers functionalized with ferulic, caffeic, and gallic acids has been obtained through a straightforward amidation reaction. Their antioxidant activity has been studied by different techniques such as DPPH (2,2'-diphenyl-1-picrylhydrazyl) radical scavenging assay, FRAP assay (ferric reducing antioxidant power), and cyclic voltammetry. The antioxidant analysis showed that polyphenolic dendrimers exhibited higher activities than free polyphenols in all cases.

Cocoa powder and catechins as natural mediators to modify carbon-black based screen-printed electrodes. Application to free and total glutathione detection in blood.

In this work, for the first time, the direct usability of natural products, catechins (CT) and cocoa powder (CO), as electrochemical mediators able to modify a carbon black modified screen-printed electrode (SPE-CB) is proved, and, as proof of applicability, free (GSH) and total glutathione (GSH + GSSG) in blood samples is successfully determined. Noteworthy, the cocoa powder (naturally rich in catechins), dissolved in DMSO, was able to give rise to a useful highly redox-active catechol-quinone surface-confined system onto a carbon black nanoparticles modified screen-printed electrode (SPE-CB-CO - Cocoatrode), giving rise to a similar behaviour obtained with pure catechins (SPE-CB-CT). The electrodeposition process has been carefully studied, the resulting immobilized natural mediator (obtained using both CT and CO) features investigated, and the performance of the resulting sensors (SPE-CB-CT and Cocoatrode) tested and compared.

Nanohybrid carbon black-molybdenum disulfide transducers for preconcentration-free voltammetric detection of the olive oil o-diphenols hydroxytyrosol and oleuropein.

A new hybrid nanomaterial is used in a screen-printed electrode (SPE) for sensing of the ortho-diphenols oleuropein (OLEU) and hydroxytyrosol (HYT) in extra virgin olive oil (EVOO) and related samples. The hybrid material consists of carbon black (CB) and molybdenum disulfide (MoS). In comparison with individual nanomaterials, CB-MoS exhibits improved charge-transfer ability, low charge-transfer resistance, high electrical conductivity and enhanced electrocatalysis.

Peripheral blood mononuclear cells as a laboratory to study dementia in the elderly.

The steady and dramatic increase in the incidence of Alzheimer's disease (AD) and the lack of effective treatments have stimulated the search for strategies to prevent or delay its onset and/or progression. Since the diagnosis of dementia requires a number of established features that are present when the disease is fully developed, but not always in the early stages, the need for a biological marker has proven to be urgent, in terms of both diagnosis and monitoring of AD. AD has been shown to affect peripheral blood mononuclear cells (PBMCs) that are a critical component of the immune system which provide defence against infection.