2 results match your criteria: "and Developmental Biology and the Molecular Biology Institute[Affiliation]"
Inhibition of angiogenesis by thrombospondin-1 is mediated by 2 independent regions within the type 1 repeats.
Circulation
September 1999
Department of Molecular, Cell, and Developmental Biology and the Molecular Biology Institute, UCLA, Los Angeles, Calif 90095, USA.
Background: Suppression of tumor growth by thrombospondin-1 (TSP-1) has been associated with its ability to inhibit neovascularization. The antiangiogenic activity of TSP-1, as defined by cornea pocket assays, was previously mapped to the amino-terminal portion of the protein within the procollagen region and the type 1 repeats.
Methods And Results: We evaluated the specificity and efficacy of different regions of TSP-1 using recombinant fragments of the protein on chorioallantoic membrane (CAM) angiogenesis and endothelial cell proliferation assays.
Toward a cancer therapy with boron-rich oligomeric phosphate diesters that target the cell nucleus.
Proc Natl Acad Sci U S A
January 1999
Department of Molecular, Cell, and Developmental Biology and the Molecular Biology Institute, University of California, 405 Hilgard Avenue, Los Angeles, CA 90095, USA.
The viability of boron neutron capture therapy depends on the development of tumor-targeting agents that contain large numbers of boron-10 (10B) atoms and are readily taken up by cells. Here we report on the selective uptake of homogeneous fluorescein-labeled nido-carboranyl oligomeric phosphate diesters (nido-OPDs) by the cell nucleus and their long-term retention after their delivery into the cytoplasm of TC7 cells by microinjection. All nido-OPDs accumulated in the cell nucleus within 2 h after microinjection.
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