The Role of Insulin Within the Socio-Psycho-Biological Framework in Type 2 Diabetes-A Perspective from Psychoneuroimmunology.

The interplay between socio-psychological factors and biological systems is pivotal in defining human health and disease, particularly in chronic non-communicable diseases. Recent advancements in psychoneuroimmunology and mitochondrial psychobiology have emphasized the significance of psychological factors as critical determinants of disease onset, progression, recurrence, and severity. These insights align with evolutionary biology, psychology, and psychiatry, highlighting the inherent social nature of humans.

School leadership fostering mental health in the times of crisis: synthesis of school principals' views and PISA 2022.

Administration and governance of schools including many complex processes like bureaucracy, teaching, and school improvement is responsibility school principals. They are like bridges between micro-level dynamics and macro-level policies. Additionally, Turkey has experienced crises like pandemic and natural disasters in the recent years.

Investigating the impact of COVID-19 related worries and loneliness on alcohol consumption: an ecological momentary assessment.

Adverse alcohol consumption is a major public health concern, which might have been further increased by the COVID-19 pandemic. In this study we investigated the impact of a lockdown stage on the association between alcohol consumption, loneliness, and COVID-19-related worries. We used smartphone-based Ecological Momentary Assessment (EMA) conducted during the COVID-19 pandemic in Germany.

Implementation strategies to support recovery support workers serving criminal legal involved people who use drugs.

Introduction: Recovery support workers (RSWs) who provide social support interventions for people who use drugs (PWUD) often face challenges that can jeopardize the well-being, efficacy and sustainability of this essential workforce. To date, little has been reported on the types of implementation strategies used to support RSWs. We describe and evaluate a multifaceted implementation strategy package to support Reducing Opioid Mortality in Illinois (ROMI), a paired peer recovery coach and case manager (PRC-CM) intervention for PWUD with recent criminal-legal involvement in urban and rural settings.

Utilization of Vestibular Information for Balance Control in Children with Chiari I Malformation.

(1) Background: Surgery for Chiari I malformation (CMI) is indicated when typical clinic-radiological features (syringomyelia, exertional headaches, sleep apnea syndrome, and tetraparesis) are present. Sometimes, patients have atypical complaints suggestive of otolaryngological (ENT) involvement, and it is sometimes difficult for the neurosurgeon to determine if these complaints are related to the CMI. Our aim was to describe postural control patterns in children with CMI using computerized dynamic posturography.

Defense mechanisms in individuals with depressive and anxiety symptoms: a network analysis.

Background: Defense mechanisms play a crucial role in depression and anxiety. The current study aimed at estimating the network structure of defense mechanisms in individuals with symptoms of depression and anxiety to understand the most central defenses and relevant connections. Moreover, we aimed at examining the associations between defense mechanisms and symptoms.

Neural divergence between individuals with and without minor depression during dynamic emotion processing: a movie-fMRI Study.

Research on the neuropathological mechanisms underlying minor depression (MD), particularly in individuals with a history of recurrent minor depressive episodes, is very limited. This study focuses on the abnormality in processing real-life emotional stimuli among individuals with MD. Thirty-two individuals with MD and 31 normal controls (NC) were recruited and underwent comprehensive clinical interview, cognitive assessment, and magnetic resonance imaging (MRI) scans.

Anxiety modulators elicit different behavioral outcomes in adult zebrafish: Emphasis on homebase-related parameters and spatio-temporal exploration.

Anxiety is an emotion that represents a crucial anticipatory reaction of aversive stimuli, with clinical relevance in cases of disproportional and severe occurrences. Although distinct animal models have contributed to elucidate anxiety-related mechanisms, the influence of anxiogenic and anxiolytic modulations on both locomotion and exploration-related parameters in the open field test (OFT) is not fully elucidated. Here, we aimed to assess the influence of anxiogenic and anxiolytic manipulations on the exploratory dynamics of adult zebrafish (Danio rerio) focusing on homebase-related behaviors.

Nurturing humanism and professionalism in a clinical setting: A multicenter study to develop a framework for a learning module for clinical students.

Introduction: Professionalism represents a contract between physicians and society, with humanism at its core. Humanism must be developed in medical education, especially in clinical settings, as students meet real-life professional situations. However, dynamic and unpredictable clinical settings might expose students to authentic yet unexpected far-from-ideal situations that might hinder the humanism and professionalism process.

Aligning Visual Prosthetic Development With Implantee Needs.

Purpose: Visual prosthetics are a promising assistive technology for vision loss, yet research often overlooks the human aspects of this technology. While previous studies focus on the perceptual experiences or attitudes of implant recipients (implantees), a systematic account of how current implants are being used in everyday life is still lacking.

Methods: We interviewed six recipients of the most widely used visual implants (Argus II and Orion) and six leading researchers in the field.

You Are as Old as the Connectivity You Keep: Distinct Neurophysiological Mechanisms Underlying Age-Related Changes in Hand Dexterity and Strength.

Background: Aging can lead to a decline in motor control. While age-related motor impairments have been documented, the underlying changes in cortico-cortical interactions remain poorly understood.

Methods: We took advantage of the high temporal resolution of dual-site transcranial magnetic stimulation (dsTMS) to investigate how communication between higher-order rostral premotor regions and the primary motor cortex (M1) influences motor control in young and elderly adults.

Transitioning to Adulthood: Pediatric Spinal Cord Injury Care and Beyond.

The transition to adulthood is a complex and dynamic process for youth with spinal cord injury (SCI). A key goal of SCI rehabilitation is to develop the skillsets necessary to successfully transition to adulthood, lead a meaningful life, engage in one's community, and maintain a good quality of life. This article provides an overview of transition outcomes and interventions within a biopsychosocial framework, with regard to physiologic functioning, participation in education and employment, emotional and social well-being, and the health care system.

Defenses and Attachment in Clinical Practice: What Came First?

Richardson, Beath, and Boag (this issue) developed a questionnaire designed to measure attachment-related defense mechanisms with considerable promise for research, practice, and training. Their robust design and the sophisticated psychometric techniques used to generate and validate the measure are notable. The goal of this commentary is to situate the measure in contemporary research on defenses, draw a distinction between defenses linked specifically to attachment and defenses more generally, and to stimulate a constructive dialogue with the (DMRS; Di Giuseppe & Perry, 2021; Perry, 1990, 2014), a model and set of measures that has dominated defense mechanism research for half a century.

Ethical issues in vaccine trial participation by adolescents: qualitative insights on family decision making from a human papillomavirus vaccine trial in Tanzania.

Background: Research in children is essential for them to benefit from the outcomes of research but involvement must be weighed against potential harms. In many countries and circumstances, medical research legally requires parental consent until the age of 18 years, with poorly defined recommendations for assent prior to this. However, there is little research exploring how these decisions are made by families and the ethical implications of this.

A qualitative study exploring the clinical phenomenology and impact of hypersexuality in patients with Parkinson's Disease.

Hypersexuality (HS) is a complex yet underreported phenomenon in Parkinson's disease (PD), profoundly impacting patients' lives. This study aims to systematically investigate the clinical phenomenology and manifestations of HS using qualitative methodologies. This phenomenological qualitative research study employed semi-structured interviews to examine hypersexuality and its impact among nine English-speaking individuals with PD.

Reconfiguration of functional brain network organization and dynamics with changing cognitive demands in children with attention-deficit/hyperactivity disorder.

Background: The pathophysiology of attention-deficit/hyperactivity disorder (ADHD) is characterized by atypical brain network organization and dynamics. Although functional brain networks adaptively reconfigure across cognitive contexts, previous studies have largely focused on network dysfunction during the resting-state. This preliminary study examined how functional brain network organization and dynamics flexibly reconfigure across rest and two cognitive control tasks with different cognitive demands in 30 children with ADHD and 36 typically developing (TD) children (8-12 years).

Cross-Cultural Validation of the Sexual Desire Inventory (SDI-2) in 42 Countries and 26 Languages.

Sexual desire is a complex construct with important implications for sexual functioning and well-being. In this research, we translated the Sexual Desire Inventory (SDI-2), a widely used scale for assessing sexual (desire), into 25 languages from English and used data from the International Sex Survey (ISS) to (a) investigate its psychometric properties (i.e.

Long-term taurine supplementation regulates brain mitochondrial dynamics in mice.

Background: Taurine (TAU) is the most abundant non-protein amino acid in the central nervous system (CNS). However, the molecular mechanism of TAU in the CNS is still poorly understood. Meanwhile, disruption in mitochondrial dynamics is evident in CNS disorders.

Identifying Key Competencies for Ambulance Nurses in Italy: Findings from a Modified Delphi Study.

Introduction: Prehospital emergency nursing is a critical domain requiring specialized competencies and robust clinical preparation. Nurses in this sector manage high-complexity situations necessitating a broad range of competencies. This study aimed to identify and validate the essential competencies required for specialized ambulance nurses in Italy using a modified Delphi methodology.