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Cutaneous Squamous Cell Carcinoma: Review of the Eighth Edition of the American Joint Committee on Cancer Staging Guidelines, Prognostic Factors, and Histopathologic Variants.

Adv Anat Pathol

July 2017

*Department of Dermatology, University of Florida College of Medicine, Gainesville, FL †Miraca Life Sciences Research Institute, Irving, TX ‡Miraca Life Sciences Research Institute, Newton, and Department of Dermatology at Tufts Medical Center, Boston, MA.

Cutaneous squamous cell carcinoma is the second most common form of nonmelanoma skin cancer after basal cell carcinoma and accounts for the majority of nonmelanoma skin cancer-related deaths. In 2017, the American Joint Committee on Cancer revised the staging guidelines of cutaneous squamous cell carcinoma to reflect recent evidence concerning high-risk clinicopathologic features. This update reviews the literature on prognostic features and staging, including the eighth edition of the American Joint Committee on Cancer Staging Manual.

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