703 results match your criteria: "and Dalhousie University[Affiliation]"
Cancer
January 2025
Division of Pediatric Hematology-Oncology, Department of Pediatrics, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire (CHU) de Sainte-Justine, Montreal, Quebec, Canada.
Background: Childhood obesity can result in adverse health outcomes. The objectives of this study were to describe the prevalence of obesity and determine the association between obesity at cancer diagnosis and event-free survival (EFS) and overall survival (OS) in children diagnosed with cancer in Canada.
Methods: The authors conducted a retrospective cohort study using the Cancer in Young People in Canada database, including all children with newly diagnosed cancer aged 2-18 years across Canada from 2001 to 2020.
Chest
January 2025
Florence Nightingale Faculty of Nursing, Midwifery and Palliative Care, King's College London.
Background: Delirium is a common and serious syndrome of acute brain dysfunction associated with negative outcomes. Melatonin may have a role in delirium prevention for critically ill adults based on data from non-critically ill patient populations. Our objective was to assess the feasibility of a multi-centre, randomized, placebo-controlled trial testing the hypothesis that low-dose melatonin prevents delirium in critically ill adults.
View Article and Find Full Text PDFCan Assoc Radiol J
December 2024
Rm c-159 Departments of Radiology and Epidemiology, University of Ottawa, Ottawa, ON, Canada.
Guidelines suggest the Liver Imaging Reporting and Data System (LI-RADS) may not be applicable for some populations at risk for hepatocellular carcinoma (HCC). However, data assessing the association of HCC risk factors with LI-RADS major features are lacking. To evaluate whether the association between HCC risk factors and each CT/MRI LI-RADS major feature differs among individuals at-risk for HCC.
View Article and Find Full Text PDFEur Radiol
December 2024
Department of Diagnostic Radiology, Queen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, Canada.
Objectives: To assess the natural history of incidental pancreatic cystic lesions (PCLs) and the sensitivity of surveillance guidelines to detect malignancy.
Materials And Methods: We performed a single-center retrospective analysis of incidental PCLs discovered between 2012 and 2017. Patients were identified by searching radiology reports for relevant keywords, then search results were manually reviewed to exclude patients with < 5 years of follow-up, non-incidental PCLs, known pancreatic cancer, or pancreatitis.
Curr Probl Diagn Radiol
December 2024
Department of Diagnostic Radiology, Queen Elizabeth II Health Sciences Centre and Dalhousie University. Victoria General Building, 3rd floor, 1276 South Park Street, Halifax, Nova Scotia B3H 2Y9, Canada. Electronic address:
Interpreting imaging examinations of the pancreas can be a challenge. Several different entities can mimic or mask pancreatic neoplasms, including normal anatomic variants, non-pancreatic lesions, and both acute and chronic pancreatitis. It is important to distinguish these entities from pancreatic neoplasms, as the management and prognosis of a pancreatic neoplasm, particularly adenocarcinoma, have considerable impact on patients.
View Article and Find Full Text PDFBrain Spine
November 2024
Department of Neurosurgery, University Neurosurgical Centre Holland (UNCH), Leiden University Medical Centre, Haaglanden Medical Center and Haga Teaching Hospital, Leiden, The Hague, the Netherlands.
Introduction: In 1960, Lazorthes and Campman introduced the concept of a which gained prominence in the field of traumatic brain injury (TBI), where it relates to neurological deterioration on the third day after injury. However, evidence regarding this phenomenon remains scarce.
Research Question: This study aimed to analyze posttraumatic intracranial pressure (ICP) patterns in a large European cohort to investigate the existence of a third-day crisis and its impact on 12-month functional outcomes.
J Neurotrauma
December 2024
Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands.
To compare the incremental prognostic value of pupillary reactivity captured as part of the Glasgow Coma Scale-Pupils (GCS-P) score or added as separate variable to the GCS+P, in traumatic brain injury (TBI). We analyzed patients enrolled between 2014 and 2018 in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI, = 3521) and the Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI, = 1439) cohorts. Logistic regression was utilized to quantify the prognostic performances of GCS-P (GCS minus number of unreactive pupils) and GCS+P versus GCS alone according to Nagelkerke's .
View Article and Find Full Text PDFJ Rheumatol
December 2024
Alexandra Legge, MD, MSc, Division of Rheumatology and Department of Medicine, QEII Health Sciences Centre and Dalhousie University, Halifax, Nova Scotia; Arthritis Research Canada, Richmond, British Columbia, Canada.
J Cutan Med Surg
December 2024
Department of Diagnostic and Molecular Pathology, Memorial University of Newfoundland, Health Sciences Centre, St. John's, NL, Canada.
The emergence of pathologist-driven molecular reflex testing for tumoural biomarkers is a significant advancement in cancer diagnostics, facilitating targeted cancer therapy for our patients. Based on our experience, the Canadian landscape of pathologist-driven reflex biomarker testing for melanoma lacks standardization and is plagued by a lack of awareness by pathologists and clinicians. This paper comprehensively examines the approaches to reflex biomarker testing for melanoma patients across Canada, highlighting the regional variations in the criteria for initiating molecular testing, the biomarkers tested, and the molecular techniques employed.
View Article and Find Full Text PDFFront Oncol
November 2024
Cross Cancer Institute, Edmonton, AB, Canada.
Background: T-cell-redirecting therapies, such as bispecific antibodies and chimeric antigen receptor T-cells, exploit the cytotoxic capabilities of the immune system to destroy cells expressing specific surface antigens, including malignant cells. These therapies have demonstrated unprecedented rates, depth, and duration of responses in relapsed and refractory multiple myeloma. However, there are significant challenges in implementing these therapies into practice, which require multidisciplinary and multicenter coordination and significant healthcare resources to effectively manage these patients.
View Article and Find Full Text PDFHeart Rhythm
December 2024
Department of Medicine, QEII Health Sciences Centre and Dalhousie University, Halifax, Nova Scotia, Canada. Electronic address:
Background: The long-term effects of catheter ablation (CA) compared with medical therapy on cardiovascular outcomes for atrial fibrillation (AF) remain undetermined.
Objective: Using a population-based cohort, we sought to determine what the association between CA and medical therapy was on these outcomes.
Methods: By use of Alberta administrative data, patients with AF as the primary diagnosis during hospitalization, emergency department visit, or physician visit were included between October 1, 2008, and March 31, 2018.
Can J Surg
November 2024
From St. Michael's Hospital (Naveed, Deshpande, Gomez, Rezende-Neto, Ahmed, Beckett), and the University of Toronto (Naveed).
J Glob Health
November 2024
University Neurosurgical Centre Holland (UNCH), Leiden University Medical Centre, Haaglanden Medical Centre and Haga Teaching Hospital, Department of Neurosurgery, Leiden and The Hague, The Netherlands.
Lancet Reg Health Am
November 2024
Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, United States.
Background: Contemporary surgical practices for traumatic brain injury (TBI) remain unclear. We describe the clinical profile of an 18-centre US TBI cohort with cranial surgery.
Methods: The prospective, observational Transforming Research and Clinical Knowledge in Traumatic Brain Injury Study (2014-2018; ClinicalTrials.
Arthritis Care Res (Hoboken)
October 2024
British Columbia Children's Hospital, Vancouver, British Columbia, Canada.
J Otolaryngol Head Neck Surg
October 2024
Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, Queen Elizabeth II Health Science Centre and Dalhousie University, Halifax, NS, Canada.
Can Assoc Radiol J
October 2024
The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.
Pediatr Blood Cancer
January 2025
Department of Pediatrics, Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas, USA.
Cancer Med
October 2024
Department of Pathology, QEII Health Sciences Centre and Dalhousie University, Halifax, Nova Scotia, Canada.
N Engl J Med
September 2024
From the Department of Medicine, University of British Columbia, Vancouver, and Dalhousie University, Halifax, NS - both in Canada (L.Y.C.C.); and the Departments of Radiology (A.J.H.), Medicine (J.H.S.), and Pathology (J.A.F.), Massachusetts General Hospital, and the Departments of Radiology (A.J.H.), Medicine (J.H.S.), and Pathology (J.A.F.), Harvard Medical School - both in Boston.
Temperature (Austin)
June 2024
Human and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa, Ottawa, ON, Canada.
The likelihood of exposure to overheated indoor environments is increasing as climate change is exacerbating the frequency and severity of hot weather and extreme heat events (EHE). Consequently, vulnerable populations will face serious health risks from indoor overheating. While the relationship between EHE and human health has been assessed in relation to outdoor temperature, indoor temperature patterns can vary markedly from those measured outside.
View Article and Find Full Text PDFBrain Spine
July 2024
University Neurosurgical Center Holland (UNCH), Leiden University Medical Center (LUMC), Haaglanden Medical Center (HMC) and Haga Teaching Hospital, Department of Neurosurgery, Leiden and The Hague, the Netherlands.
Introduction: Acute subdural hematoma (ASDH) due to traumatic brain injury (TBI) constitutes an increasing global health problem, especially in the elderly population. Treatment decisions on surgical versus conservative management pose a neurosurgical dilemma. Large practice variation exists between countries, hospitals, and individual neurosurgeons, illustrating the presence of 'clinical equipoise'.
View Article and Find Full Text PDFPLoS One
August 2024
Public Health Ontario, Toronto, Ontario, Canada.
Introduction: The incidence of varicella in Canada has decreased by almost 99% since vaccination was introduced. However, variation in the timing and eligibility of vaccination programs across the country has resulted in some cohorts being under-vaccinated and therefore potentially susceptible to infection.
Methods: We used nationally representative specimens from the Biobank of Statistics Canada's Canadian Health Measures Survey (CHMS) as well as residual specimens from Ontario collected between 2009-2014 to estimate population immunity across age-groups and geography, and identify any groups at increased risk of varicella infection.
Can J Hosp Pharm
August 2024
MD, PhD, FRCPC, is a Clinician Scientist, Division of Infectious Diseases, Nova Scotia Health, and Assistant Professor, Division of Infectious Diseases, Department of Medicine, Dalhousie University, Halifax, Nova Scotia.
Sci Transl Med
July 2024
Charles Perkins Centre, Dr. John and Anne Chong Lab for Functional Genomics, and School of Life and Environmental Sciences, University of Sydney, Camperdown, NSW 2006, Australia.
Snakebites affect about 1.8 million people annually. The current standard of care involves antibody-based antivenoms, which can be difficult to access and are generally not effective against local tissue injury, the primary cause of morbidity.
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