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Dominant T cells in idiopathic nephrotic syndrome of childhood.
Kidney Int
February 2000
Children's Hospital and Institute for Clinical Immunology, Friedrich-Alexander University, Erlangen-Nuremberg, and Children's Rheumatology Hospital, Garmisch-Partenkirchen, Germany.
Background: Because of several studies, idiopathic nephrotic syndrome (INS) of childhood is suspected to have an immunologic pathogenesis with T cells playing a major role. To investigate this hypothesis further, we studied the diversity of the CDR3 region of the T-cell receptor (TCR) beta-chain from peripheral T cells isolated from patients with INS.
Methods: The study was performed over a three-year period to obtain longitudinal data on the repertoire of peripheral T cells.