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Hepatitis C virus among blood donors: follow-up study.

Transfusion

June 1994

Institut National de la Santé et de la Recherche Médicale, Centre International de Recherche sur le Cancer, and Centre Regional de Transfusion Sanguine, Lyon, France.

Background: The exact significance of antibodies to hepatitis C virus (HCV) in blood donors remains unknown. Confirmatory tests of anti-HCV-reactive serum and HCV RNA by polymerase chain reaction (PCR) are used to refute a large proportion of false-positive results.

Study Design And Methods: Ninety-two blood donors who were anti-HCV reactive in a first-generation enzyme-linked immunosorbent assay (ELISA) were reevaluated 10 months later with a second-generation ELISA (ELISA-2) as well as with second-generation recombinant immunoblot assay (RIBA-2) and by PCR.

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