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Vitamin E uncouples joint destruction and clinical inflammation in a transgenic mouse model of rheumatoid arthritis.
Arthritis Rheum
February 2002
INSERM U479, Faculté Xavier Bichat, and Centre Hospitalo-Universitaire Xavier Bichat, 46 rue Henri Huchard, Paris 75018, France.
Objective: Reactive oxygen species are thought to play a role in rheumatoid arthritis (RA) in humans. We postulated that antioxidant treatment could have a beneficial effect in this disease. We therefore investigated the effects of vitamin E in the transgenic KRN/NOD mouse model of RA.
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