1 results match your criteria: "and Center for Biotechnology and Drug Design Georgia State University[Affiliation]"
Rapid and specific post-synthesis modification of DNA through a biocompatible condensation of 1,2-aminothiols with 2-cyanobenzothiazole.
Chemistry
March 2013
Department of Chemistry, Center for Diagnostics and Therapeutics, and Center for Biotechnology and Drug Design Georgia State University, P.O. Box 4098, Atlanta, GA 30302-4098.
Post-synthesis modification of DNA is an important way of functionalizing DNA molecules. Herein, we describe a method that first enzymatically incorporates a cyanobenzothiazole (CBT)-modified thymidine. The side-chain handle CBT can undergo a rapid and site-specific cyclization reaction with 1,2-aminothiols to afford DNA functionalization in aqueous solution.
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