2 results match your criteria: "and Bronx Veteran's Affairs Geriatric Research Education and Clinical Center[Affiliation]"
Calcitonin: the other thyroid hormone.
Thyroid
September 2002
Mount Sinai Bone Program, Department of Medicine, Mount Sinai School of Medicine, and Bronx Veteran's Affairs Geriatric Research Education and Clinical Center (GRECC), New York, New York 10029, USA.
Calcitonin was originally discovered as a hypocalcemic factor synthesized by thyroid parafollicular C cells. Early experiments demonstrated that calcitonin inhibited bone resorption and decreased calcium efflux from isolated cat tibiae and subsequent histologic and culture studies confirmed the osteoclast as its major site of action. Its potent antiresorptive effect and analgesic action have led to its clinical use in treatment of Paget's bone disease, osteoporosis, and hypercalcemia of malignancy.
View Article and Find Full Text PDFIdentification and characterization of a sodium/calcium exchanger, NCX-1, in osteoclasts and its role in bone resorption.
Biochem Biophys Res Commun
May 2001
Mount Sinai Bone Program, Department of Medicine, Mount Sinai School of Medicine, and Bronx Veteran's Affairs Geriatric Research Education and Clinical Center, New York, New York 10029, USA.
We provide the first demonstration for a Na+/Ca2+ exchanger, NCX-1, in the osteoclast. We speculate that by using Na+ exchange, NCX-1 couples H+ extrusion with Ca2+ fluxes during bone resorption. Microspectrofluorimetry of fura-2-loaded osteoclasts revealed a rapid and sustained, but reversible, cytosolic Ca2+ elevation upon Na+ withdrawal.
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