2 results match your criteria: "and Biotechnologies University of Perugia Perugia Italy.[Affiliation]"

Chronic lithium administration in a mouse model for Krabbe disease.

JIMD Rep

January 2022

NEST, Istituto Nanoscienze-CNR and Scuola Normale Superiore, Piazza San Silvestro Pisa Italy.

Krabbe disease (KD; or globoid cell leukodystrophy) is an autosomal recessive lysosomal storage disorder caused by deficiency of the galactosylceramidase (GALC) enzyme. No cure is currently available for KD. Clinical applied treatments are supportive only.

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Article Synopsis
  • Salmonids in Mediterranean rivers, particularly in the Tiber River basin, face threats from habitat changes, overfishing, climate change, and hybridization with non-native species, complicating conservation efforts.
  • The study aims to understand how climate change affects trout populations by examining their distribution and ecological status over the past few decades, with data collected from 129 sites across three census periods.
  • Findings indicate trout populations show resilience despite environmental changes, but declining body conditions and age imbalances present concerns for their future, as habitat availability becomes critical amidst rising temperatures and altered water conditions.
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