3 results match your criteria: "and Autonomous University of Madrid (UAM)[Affiliation]"
Atherosclerotic plaque development in mice is enhanced by myeloid ZEB1 downregulation.
Nat Commun
December 2023
Group of Gene Regulation in Stem Cells, Cell Plasticity, Differentiation, and Cancer, IDIBAPS, 08036, Barcelona, Spain.
Article Synopsis
- Accumulation of lipid-laden macrophages is vital in forming atherosclerotic plaques, and reduced ZEB1 levels in these cells lead to larger plaques and increased cardiovascular risk.
- Male mice lacking ZEB1 in myeloid cells show significant lipid build-up and metabolic issues, indicating that ZEB1 deficiency worsens atherosclerosis.
- Targeted delivery of ZEB1 using nanoparticles can reverse lipid accumulation and reduce plaque formation, suggesting that ZEB1 could be an important therapeutic target for atherosclerosis.
Inflammatory macrophages reprogram to immunosuppression by reducing mitochondrial translation.
Nat Commun
November 2023
Group of Gene Regulation in Stem Cells, Cell Plasticity, Differentiation, and Cancer, IDIBAPS, 08036, Barcelona, Spain.
Acute inflammation can either resolve through immunosuppression or persist, leading to chronic inflammation. These transitions are driven by distinct molecular and metabolic reprogramming of immune cells. The anti-diabetic drug Metformin inhibits acute and chronic inflammation through mechanisms still not fully understood.
View Article and Find Full Text PDFEuropean Registry on the management of Helicobacter pylori infection (Hp-EuReg): analysis of 2360 patients receiving first-line therapy in Russia.
Ter Arkh
February 2018
Gastroenterology Unit, University Hospital «Princess», the Institute of Research in Health "Princess" (IIS-IP), Biomedical Research Centre Network of Hepatic and Digestive Diseases (CIBERehd), and Autonomous University of Madrid (UAM), Madrid, Spain.
Aim: European Registry on the management of Helicobacter pylori infection («Hp-EuReg») - a multicenter prospective observational study initiated by the European Helicobacter and Microbiota Study Group, conducted in 27 European countries in order to evaluate the real clinical practice of diagnosis and treatment of H. pylori and its comparison with international recommendations.
Materials And Methods: The analysis of 2360 patients entered in the register by the Russian centres of «Hp-EuReg» in 2013-2017, who were underwent 1st line eradication therapy.