3 results match your criteria: "and Applied Translational Research (ATR) Center (G.F.)[Affiliation]"
Adipose Stromal Cell Spheroids for Cartilage Repair: A Promising Tool for Unveiling the Critical Maturation Point.
Bioengineering (Basel)
October 2023
Laboratorio RAMSES, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.
Article Synopsis
- Articular cartilage has limited regenerative abilities and existing treatments mainly provide temporary pain relief, spurring interest in tissue engineering.
- This study focused on the potential of adipose stromal cells to form spheroids and differentiate into cartilage-like structures for improved cartilage repair.
- Spheroids created using 3D chips showed promising characteristics and maturation, indicating they could be effective in developing cartilage organoids for future clinical applications, including personalized therapies.
Cell-Free Biomimetic Osteochondral Scaffold: Implantation Technique.
JBJS Essent Surg Tech
August 2019
II Orthopedic and Traumatologic Clinic (A.S., A.D.M., and S.Z.), Knee and Hip Replacement Department (F.P.), and Applied Translational Research (ATR) Center (G.F.), IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Unlabelled: This 1-stage cell-free scaffold-based technique is indicated for the treatment of full-thickness chondral and osteochondral lesions in the knee, regardless of the lesion size. The aim of the procedure is restoration of the osteochondral unit while avoiding the issues of donor site morbidity and those related to cell management.
Description: The surgical technique is simple and can be performed as a 1-stage procedure.
Cell-Free Osteochondral Scaffold for the Treatment of Focal Articular Cartilage Defects in Early Knee OA: 5 Years' Follow-Up Results.
J Clin Med
November 2019
Applied Translational Research (ATR) Center, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.
The purpose of this study was to investigate the clinical results at five years' follow-up of a tri-layered nanostructured biomimetic osteochondral scaffold used for focal articular cartilage defects in patients meeting the criteria of early osteoarthritis (EOA). The study population comprised 22 patients (mean age: 39 years), prospectively assessed before surgery, at 24 and 60 months' follow-up. Inclusion criteria were: at least two episodes of knee pain for more than 10 days in the last year, Kellgren-Lawrence OA grade 0, I or II and arthroscopic or MRI findings according to the European Society of Sports Traumatology, Knee Surgery & Arthroscopy (ESSKA) criteria.
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