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The role of CKIP-1 in osteoporosis development and treatment.
Bone Joint Res
February 2018
Department of Orthopaedics and Traumatology, People's Hospital of Bao'an District, Affiliated to Southern Medical University, and Affiliated to Guangdong Medical University, Longjing 2nd Rd, Bao'an District, Shenzhen, China.
Osteoporosis is a systemic skeletal disorder characterized by reduced bone mass and deterioration of bone microarchitecture, which results in increased bone fragility and fracture risk. Casein kinase 2-interacting protein-1 (CKIP-1) is a protein that plays an important role in regulation of bone formation. The effect of CKIP-1 on bone formation is mainly mediated through negative regulation of the bone morphogenetic protein pathway.
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