2 results match your criteria: "and †Children's Hospital of Michigan[Affiliation]"
Acquired Aplastic Anemia: What Have We Learned and What Is in the Horizon?
Pediatr Clin North Am
June 2018
Division of Hematology/Oncology, Pediatric Blood and Marrow Transplant Program, Children's Hospital of Michigan, Barbara Ann Karmanos Cancer Center, Wayne State University School of Medicine, 3901 Beaubien Boulevard, Detroit, MI 48201, USA. Electronic address:
Acquired aplastic anemia (aAA) characterized by peripheral pancytopenia and bone marrow aplasia is a rare and serious disorder. Differential diagnosis includes constitutional bone marrow failure syndromes and myelodysplastic disorders. Autoimmune reaction to altered hematopoietic stem cells highlights the underlying mechanism.
View Article and Find Full Text PDFEvidence for Increased Response to Induced Endoplasmic Reticulum Stress in Myeloid Cells in Acquired Aplastic Anemia.
J Pediatr Hematol Oncol
April 2017
*Department of Pediatrics and Human Development, Michigan State University, East Lansing, MI †Department of Pediatrics, Wayne State University School of Medicine, Children's Hospital of Michigan ‡Molecular Therapeutics Program, Karmanos Cancer Institute §Pediatric Blood and Marrow Transplant Program, Children's Hospital of Michigan, Barbara Ann Karmanos Cancer Center, Detroit, MI.
Autoimmune response targeting the hematopoietic stem cells highlights the current understanding of acquired aplastic anemia (AAA) pathogenesis. Upregulation of the unfolded protein response is the cell's rejoinder to a variety of stresses, which either result in restoring homeostasis or cell death by increased expression of the transcription factor C/EBP homologous protein. We hypothesized that there is an inherent increased sensitivity to various cellular stressors, including the ones that target endoplasmic reticulum (ER) in AAA leading to a decreased proliferation and potentially contributing to susceptibility to autologous cytotoxicity.
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