298 results match your criteria: "affiliated with the Sackler School of Medicine[Affiliation]"

Article Synopsis
  • The study aimed to compare LASIK surgery outcomes among patients with varying corneal curvatures (flat, normal, and steep).
  • A total of 300 eyes from each curvature group were analyzed after matching for baseline characteristics, with primary outcomes including visual acuity and astigmatism.
  • Results showed no significant differences in postoperative effectiveness or safety between the groups, indicating that LASIK is equally safe and effective regardless of corneal curvature.
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Prevalence and Risk Factors for Chronic Postsurgical Pain After Thoracic Surgery: A Prospective Cohort Study.

J Cardiothorac Vasc Anesth

February 2024

Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, Ontario, Canada; Department of Anesthesia and Pain Management, Toronto General Hospital, Toronto, Ontario, Canada.

Objective: Thoracic surgery is associated with one of the highest rates of chronic postsurgical pain (CPSP) among all surgical subtypes. Chronic postsurgical pain carries significant medical, psychological, and economic consequences, and further interventions are needed to prevent its development. This study aimed to determine the prevalence, characteristics, and risk factors associated with CPSP after thoracic surgery.

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Introduction: The femur is a common site for Multiple Myeloma (MM) involvement. This study explores the impact of preventive surgery for anticipated femoral pathological fractures (IFF), based on Mirels classification, versus treatment of pathological femur fracture (PFF) on MM patient mortality and morbidity.

Methods: Retrospective cohort of 33 patients undergoing surgery due to femoral MM involvement (2004-2015), 18 patients with PFF, 15 patients with IFF, followed up until deceased or to July 2016.

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Purpose: Hypotension after induction of general anesthesia is common and is associated with significant adverse events. Identification of patients at high risk can inform the use of preoperative mitigation strategies. We conducted a systematic review and meta-analysis to assess the diagnostic accuracy of the inferior vena cava collapsibility index (IVC-CI) and maximal diameter (dIVC) in predicting postinduction hypotension and to identify their predictive performance across different threshold ranges.

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Background: Retroperitoneal sarcomas (RPSs) present a surgical challenge, with complex anatomic relationships to organs and vascular structures. This pilot study investigated the role of three-dimensional (3D) augmented reality (3DAR) compared with standard imaging in preoperative planning and resection strategies.

Methods: For the study, 13 patients who underwent surgical resection of their RPS were selected based on the location of their tumor (right, left, pelvis).

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Objectives: As point-of-care ultrasound (POCUS) has emerged as a valuable tool for intussusception screening, this quality improvement study aimed to implement a "POCUS-first" pathway in a Pediatric Emergency Department (ED) to streamline workflow and expedite care for children with suspected intussusception.

Methods: This was a prospective analysis of children diagnosed with ileocolic intussusception in a Pediatric ED between June 2022 and June 2023. The study compared the "POCUS-first" cohort with the group receiving only radiology-performed ultrasound.

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Purpose: To summarize our experience in the management of congenital anomalies in the kidney and urinary tract (CAKUT) in adults.

Materials And Methods: We conducted a retrospective chart review of all adult patients who underwent primary surgical intervention for CAKUT between 1998 and 2021.

Results: The study included 102 patients with a median age of 25 (interquartile range, 23-36.

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Decidual-tissue-resident memory T cells protect against nonprimary human cytomegalovirus infection at the maternal-fetal interface.

Cell Rep

February 2024

Clinical Virology Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel; Lautenberg Center for General and Tumor Immunology, Faculty of Medicine, The Hebrew University, Jerusalem, Israel. Electronic address:

Article Synopsis
  • Congenital cytomegalovirus (cCMV) is a major cause of neurodevelopmental disabilities in infants, highlighting the need for better prevention strategies.
  • Researchers studied human CMV infection in decidual tissues from women with and without immunity, finding that those with preconception immunity show resistance to the virus and stimulate specific immune cells upon reinfection.
  • The study suggests that enhancing the immune response in decidual tissues could help develop a vaccine for cCMV and improve understanding of immune defenses at the maternal-fetal interface.
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Photorefractive keratectomy in flat, normal, and steep corneas.

J Cataract Refract Surg

January 2024

From the Department of Ophthalmology, Tel Aviv Medical Center affiliated with the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel (Levinger); Department of Ophthalmology, Assuta-Samson Ashdod Hospital affiliated with the Faculty of Medicine, Ben Gurion University, Beer-Sheva, Israel (Arnon, Pikkel, Yahalomi); Department of Ophthalmology, Rambam Health Care Campus, Haifa, Israel (Mimouni); Bruce and Ruth Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel (Mimouni); Care-Vision Laser Centers, Tel-Aviv, Israel (Sela, Munzer, Mimouni).

Purpose: To compare photorefractive keratectomy (PRK) outcomes in patients with different corneal steepness.

Setting: Care-Vision Laser Center, Tel-Aviv, Israel.

Design: Retrospective comparative chart review.

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Background: Hiatal hernia (HH) and gastroesophageal reflux disease (GERD) are risk factors for esophageal adenocarcinoma. High positive margin rates and poor survival were described among HH patients undergoing esophagectomy. We sought to describe incidence and impact of HH on outcomes following esophagectomy.

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Sugammadex-Induced Anaphylactic Shock Reversed With Short-Term Continuous Veno-Venous Hemodiafiltration: A Case Report.

A A Pract

November 2023

From the Department of Anesthesiology, Intensive Care and Pain Medicine, Meir Medical Center, Kfar Saba, Israel, affiliated with the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Anaphylaxis is a life-threatening, systemic, hypersensitivity reaction, manifested by urticaria, hypotension, and respiratory symptoms. Antigens that are cleared renally may have protracted exposure in patients with impaired renal function, resulting in prolonged and refractory anaphylactic shock. After administration of sugammadex, a 47-year-old man developed prolonged, refractory anaphylactic shock, with anuria due to acute kidney injury.

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Repositioning of Ureteropelvic Junction in Robot-assisted Laparoscopic Pyeloplasty.

Urology

February 2024

Affiliated with the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Department of Urology, Meir Medical Center, Kfar Saba, Israel.

Objective: To describe the technique of ureteropelvic junction (UPJ) repositioning in robot-assisted dismembered pyeloplasty as a modified approach during which the UPJ is brought to a new location to facilitate the anastomosis.

Materials And Methods: Retrospective review of pediatric and adult cases of robot-assisted laparoscopic pyeloplasty performed between the years 2016 and 2022. In a select group of patients, repositioning of the UPJ was performed.

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Self-reported diagnostic confidence predicts diagnostic accuracy in axial spondyloarthritis imaging.

Rheumatology (Oxford)

August 2024

Department of Radiology, Charité - Universitätsmedizin Berlin, Campus Mitte, Humboldt-Universität zu Berlin, Freie Universität Berlin, Berlin, Germany.

Objectives: Reporting diagnostic confidence (DC) in axial spondyloarthritis (axSpA) imaging is recommended by the ASAS guidelines. Our aim was to investigate whether self-reported DC predicts diagnostic accuracy in axSpA imaging using X-ray (XR), computed tomography (CT) and magnetic resonance imaging (MRI).

Methods: We performed a post hoc analysis including 163 patients with low back pain (89 axSpA and 56 non-axSpA).

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Objectives: The effects of oxytocin (OT) administration on psychotherapeutic processes have thus far been elusive. This study explored the effect of OT administration on patient-therapist congruence of the working alliance.

Method: Inpatients with mental disorders (= 87) participating in a randomized controlled trial received OT (= 44) or placebo (= 43) intranasally twice a day, for four weeks.

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The purpose of this study was to evaluate the quality of life (QoL), early post-operative complications, and hernia recurrence rate following laparoscopic enhanced-view Totally Extra-Peritoneal (eTEP) Rives-Stoppa (RS) for incisional and primary ventral hernia repair. Retrospective review of a prospectively maintained database of all patients undergoing eTEP-RS between 2017 and 2020. Data retrieved included demographics, and clinical and operative variables.

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Combined Utero-Ovarian and Round Ligament Oophoropexy for Recurrent Torsion of Normal Adnexa: A Case Series.

J Pediatr Adolesc Gynecol

October 2023

Department of Obstetrics and Gynecology, Shamir (Assaf Harofe) Medical Center, Zerifin, Israel; affiliated with the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Study Objective: Recurrent torsion of otherwise normal adnexa (not involving adnexal cysts) has been reported in young girls and adolescents. Previous ovarian fixation techniques (oophoropexy), such as plication of the utero-ovarian ligament, appear to have limited efficacy in preventing recurrent torsion. A novel technique combining plication of the utero-ovarian ligament and suturing of the ovary to the round ligament has recently been described.

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Purpose: Assess the subjective impact of gastro-esophageal reflux disease (GERD) symptoms on patients undergoing revision from laparoscopic sleeve gastrectomy (LSG) to one-anastomosis gastric bypass (OAGB) using the Reflux Disease Questionnaire for GERD (RDQ) and the GERD-health related quality of life score (GERD-HRQL), prior to- and following conversion.

Methods: Patients undergoing revision from LSG to OAGB were prospectively followed between May 2015 and December 2020. Data retrieved included demographics, anthropometrics, previous bariatric history, time interval between LSG and OAGB, weight loss, and co-morbidities.

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IOeRT in retroperitoneal sarcoma: Towards more organ preservation with comparable oncological outcomes.

Surg Oncol

June 2023

The Department of General and Oncological Surgery - Surgery C, Sheba Medical Center, Tel Hashomer, Affiliated with the Sackler School of Medicine, Tel Aviv University Israel, Israel.

Background: Retroperitoneal sarcomas (RPS) present a surgical challenge with high rates of local recurrence (LR). We investigated the role of intraoperative electron radiotherapy (IOeRT) in reducing LR after surgical resection of RPS.

Methods: A retrospective analysis of all patients who underwent surgical resection for RPS between 2014 and 2021 at a tertiary academic referral center (n = 172).

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Childbirth is a major life event with expected positive outcomes, yet for some women postnatal psychopathological symptoms may harm women's interpersonal relationships. We hypothesized that higher levels of postnatal depression, post-traumatic stress (PTSD) symptoms, and fear of childbirth would be associated with mother-baby bond disorders and relationship dissatisfaction in couples. A cross-sectional self-report online questionnaire was used to survey partnered women who had delivered in the year prior to the study.

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A double-edged hormone: The moderating role of personality and attachment on oxytocin's treatment facilitation effect.

Psychoneuroendocrinology

May 2023

Shalvata Mental Health Center, affiliated with the Sackler School of Medicine, Tel Aviv University, Israel; Sackler School of Medicine, Tel Aviv University, Israel.

Background: Studies exploring the potential augmenting effect of oxytocin for patients with mental disorders have thus far reported mixed effects. However, oxytocin's effect may differ across patients with different interpersonal characteristics. This study aimed to examine the moderating role of attachment and personality traits on the effect of oxytocin administration on the therapeutic working alliance and symptomatic change, among hospitalized patients with severe mental illness.

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Transgender and Alagille Syndrome: A Rare Case of a Trans Woman with Alagille Syndrome.

Transgend Health

February 2023

Department of Plastic and Reconstructive Surgery, The National Burn Center, Sheba Medical Center, Tel Hashomer, Israel.

Alagille syndrome is a rare autosomal dominant disorder with variable expression. Liver damage, especially cholestatic, is the most common feature of the syndrome. Transgender patients may suffer from a great distress due to the discrepancy between assigned sex at birth and unaffirmed gender identity.

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Endometrioma increases the risk of antibiotic treatment failure and surgical intervention in patients with pelvic inflammatory disease.

Fertil Steril

June 2023

Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Ramat-Gan, affiliated with the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Objective: To evaluate the outcome of pelvic inflammatory disease (PID) in patients with endometriosis with and without ovarian endometrioma.

Design: A retrospective cohort study.

Setting: A single university-affiliated tertiary center.

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Imaging Characteristics of Diffuse Idiopathic Skeletal Hyperostosis: More Than Just Spinal Bony Bridges.

Diagnostics (Basel)

February 2023

Department of Diagnostic Imaging, Sheba Medical Center, Tel Hashomer, Affiliated with the Sackler School of Medicine, Tel Aviv University, Tel-Aviv 5265601, Israel.

Diffuse idiopathic skeletal hyperostosis (DISH) is a systemic condition characterized by new bone formation and enthesopathies of the axial and peripheral skeleton. The pathogenesis of DISH is not well understood, and it is currently considered a non-inflammatory condition with an underlying metabolic derangement. Currently, DISH diagnosis relies on the Resnick and Niwayama criteria, which encompass end-stage disease with an already ankylotic spine.

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Background: The benefit of implantable cardioverter-defibrillators (ICDs) in elderly patients is controversial.

Objectives: The aims of this study were to evaluate the risk for ventricular tachyarrhythmia (VTA) and ICD shocks by age groups and to assess the competing risk for VTA and death without prior VTA.

Methods: The study included 5,170 primary prevention ICD recipients enrolled in 5 landmark ICD trials (MADIT [Multicenter Automatic Defibrillator Implantation Trial] II, MADIT-Risk, MADIT-CRT [MADIT Cardiac Resynchronization Therapy], MADIT-RIT [MADIT Reduce Inappropriate Therapy], and RAID [Ranolazine in High-Risk Patients With Implanted Cardioverter-Defibrillator]).

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