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Urine polymerase chain reaction as a screening tool for the detection of congenital cytomegalovirus infection.
Arch Dis Child Fetal Neonatal Ed
September 2003
Shaare Zedek Medical Center, Jerusalem, affiliated with Hebrew University School of Medicine, Jerusalem, Israel.
Objectives: To define the incidence of congenital cytomegalovirus (CMV) infection in a defined population in Israel as diagnosed by urine polymerase chain reaction (PCR), and to assess the utility of this method for screening for congenital CMV infection.
Design: A convenient sample of urine specimens from asymptomatic newborns were subjected to CMV PCR. Positive results were validated by urine tube culture and by determination of serum CMV IgM antibodies.