Biomarker measurements of prenatal exposure to polychlorinated biphenyls (PCB) in umbilical cord blood from postpartum Hispanic women in Brownsville, Texas.

Biomarkers of polychlorinated biphenyls (PCB) were measured in both maternal and umbilical cord blood from 35 pregnant Hispanic women living in Brownsville, TX. Gas chromatography with an electron capture detector (GC/ECD) was used to analyze for 22 PCB analytes. Results indicated that both pregnant mothers and their fetuses were exposed to a variety of PCB at relatively low levels (≤ 0.

Predictors of attrition from an expressive writing intervention for sexual abuse survivors.

This study examined predictors of attrition from a clinical trial examining the effects of an expressive writing intervention for sexual problems among female survivors of child sexual abuse. Participants were 124 women all reporting sexual difficulties, who were randomized to a trauma-focused condition (n = 45), an experimental sexual schema-focused condition (n = 37), or a control condition (n = 42). Thirty-five women (28%) dropped out before completing posttreatment assessments.

The Case for Use of Simple Difference Scores to Test the Significance of Differences in Mean Rates of Change in Controlled Repeated Measurements Designs.

A previous Monte Carlo study examined the relative powers of several simple and more complex procedures for testing the significance of difference in mean rates of change in a controlled, longitudinal, treatment evaluation study. Results revealed that the relative powers depended on the correlation structure of the simulated repeated measurements. Tests on dropout-weighted linear slope coefficients fitted to all of the available measurements for each participant were found to provide superior power in the presence of compound symmetry (CS), but tests of significance applied to simple baseline-to-endpoint difference scores provided superior power in the presence of a strongly autoregressive (AR) correlation structure.

A Comparative Investigation of Rotation Criteria Within Exploratory Factor Analysis.

Exploratory factor analysis (EFA) is a commonly used statistical technique for examining the relationships between variables (e.g., items) and the factors (e.

Exenatide: first-in-class incretin mimetic for the treatment of Type 2 diabetes mellitus.

Exenatide is the first-in-class incretin mimetic for the treatment of Type 2 diabetes mellitus. Mechanistically, it mimics several of the glucoregulatory effects of glucagon-like peptide-1 including: 1) glucose-dependent insulin secretion via the glucose-dependent glucagon-like peptide-1 pancreatic receptor; 2) suppression of elevated plasma glucagon levels; 3) reduction in the rate of appearance of glucose into the systemic circulation by normalizing the accelerated rate of gastric emptying often present in Type 2 diabetes mellitus; 4) reduction of food intake, which in turn promotes weight loss; 5) stimulation of the glucagon-like peptide-1 receptor. AC reductions of approximately 1% can be expected with a baseline AC of 8.

How Do Proteins Recognize DNA? Solution Structure and Local Conformational Dynamics of Lac Operators by 2D NMR.

Abstract The NMR structures of the symmetrical lac operator DNA fragment, d(TGTGAGCGCTCACA)(2) and it's mutant, d(TATGAGCGCTCATA)(2), were determined by the MORASS hybrid relaxation matrix/restrained molecular dynamics methodology. The (1)H chemical shifts of nearly all of the non-exchangeable protons were assigned using standard two-dimensional NMR techniques. Ultimately, 181 NOE volumes/strand were used in the final MORASS structural determination for each molecule.

New Agents and Strategies in CLL Treatment.

Fludarabine Monophosphate (FLU) is an adenosine analogue with a high-level of anti-leukemic activity in patients (pts) with CLL. FLU (25-30 mg/m(2)/day × 5 every 4 weeks) was given to 78 previously treated pts with CLL. The overall response rate was 58% (CR 11%, nodular CR 26%, PR 21%).

Psychoeducational Services for Children and Youth in the Orient: Current Status, Problems, and some Remedies.

Utilizing information obtained through an international survey and existing literature, patterns in the practices, research, and preparation of professionals who deliver psychoeducational services to children and youth in six Oriental countries (i.e., China, Hong Kong(1), Japan, the Philippines, Taiwan, and Thailand) are described.

Naproxen sodium in treatment of bone pain due to metastatic cancer.

This multicenter, double-blind, randomized, parallel study compared the efficacy and safety of two dosages of naproxen sodium (NS) in 100 patients with bone pain due to metastatic cancer. Patients were asked to rate their pain on a scale of 0-99; those patients with pain scores of 40 or more (indicating moderate to severe pain) were enrolled. Patients receiving the high-dosage regimen (HDR; n = 51) received NS 550 mg every 8 h for 3 days.

Sexual history taking.

Including in the routine medical history some basic questions regarding sexual functioning can help to identify persons with sexual problems and to encourage future dialogue. The first step in counseling is to obtain a history of the patient's specific complaint. The aim is to collect pertinent information while creating a climate in which to discuss sexual problems.

Learning and Processes of Associative Mediation.

In the attempt to evaluate product and process views of associative mediation, 80 male and female university students learned paired-associate lists under one of several instructional sets. Those with mediation instructions wrote down associative mediators on cards-with (Intentional) or without (Incidental) instructions to learn the pairs--as pairs were projected onto a daylight screen. Others learned with Standard or Repetition instructions.

Forgetting of Acquisition and Extinction in an Invertebrate.

Two experiments with isopods, Armadillidium vulgare, were reported. In Experiment I, two groups of five Ss each learned to run a T maze to escape light and heat. Both original learning (OL), and relearning (RL) the next day, were to a criterion 9/10 correct.

Category and Position Competition in Free Recall.

The present two experiments were designed to investigate the effects of two competing retrieval strategies-category and position cueing. One hundred college students participated in Experiment I in which Presentation Rate, List Type, and Stimulus Position were manipulated within an FR paradigm. Sixty students participated in Experiment II in which Formal Response Similarity and Stimulus Position were manipulated within a PA paradigm.

ASSOCIATION STRUCTURES OF MENTAL RETARDATES.

Free word associations of low level retardates (I.Q., 48) and higher level (I.