Pharmacotherapy for generalized anxiety disorder in adult and pediatric patients: an evidence-based treatment review.

Generalized anxiety disorder (GAD) often begins during adolescence or early adulthood and persists throughout the lifespan. Randomized controlled trials support the efficacy of selective serotonin and selective serotonin norepinephrine reuptake inhibitors (SSRIs and SNRIs, respectively), as well as benzodiazepines, azapirones, anti-adrenergic medications, melatonin analogs, second-generation antipsychotics, kava, and lavender oil in GAD. However, psychopharmacologic treatment selection requires clinicians to consider multiple factors, including age, co-morbidity, and prior treatment.

Step-up and step-down treatments for optimal asthma control in children and adolescents.

Objective: To review therapeutic options for stepwise management of pediatric asthma in the context of this population's unique needs such as potential effects of asthma, treatments, or both on growth and psychosocial development, and caregiver involvement.

Data Sources And Study Selection: We conducted PubMed searches to identify relevant articles then reviewed resultant articles, guidelines for asthma management in children, and articles from personal files.

Results: Stepwise management of asthma, similar to adults, is recommended for children in current global and US guidelines.

Treatment of severe, uncontrolled eosinophilic asthma: Where we are heading.

Objective: We sought to highlight how our understanding of the pathophysiology of severe asthma has evolved over time and discuss the role of biomarkers in treatment advances and emerging new therapies.

Data Sources: Nonsystematic PubMed literature search.

Study Selection: Articles were selected based on areas of relevance to the classification of asthma by endotype, with an emphasis on the evolution of current treatment guidelines for severe asthma.

Psychosocial risks of prescription drug misuse among U.S. racial/ethnic minorities: A systematic review.

Prescription drug misuse (PDM) is the leading cause of accidental death in the U.S. One in five Americans report at least one lifetime incident of PDM.

Experimental Power for Indirect Effects in Group-randomized Studies with Group-level Mediators.

Mediation analyses have provided a critical platform to assess the validity of theories of action across a wide range of disciplines. Despite widespread interest and development in these analyses, literature guiding the design of mediation studies has been largely unavailable. Like studies focused on the detection of a total or main effect, an important design consideration is the statistical power to detect indirect effects if they exist.

Once-daily fluticasone furoate/vilanterol versus twice-daily fluticasone propionate/salmeterol in patients with asthma well controlled on ICS/LABA.

Objective: We aimed to demonstrate non-inferiority of once-daily fluticasone furoate/vilanterol 100/25 µg (FF/VI) to twice-daily fluticasone propionate/salmeterol 250/50 µg (FP/SAL) in adults/adolescents with asthma well controlled on inhaled corticosteroid/long-acting β agonist (ICS/LABA).

Methods: This was a randomized, double-blind, double-dummy, parallel-group, 24-week study (NCT02301975/GSK study 201378). Patients whose asthma met study-defined criteria for control were randomized 1:1:1 to receive FF/VI, FP/SAL or twice-daily FP 250 µg for 24 weeks.

Comparable efficacy of behavioral and pharmacological treatments among African American and White cocaine users.

Multiple randomized clinical trials (RCTs) have evaluated a range of treatments for cocaine dependence, but few of these have focused specifically on the racial diversity observed among cocaine-dependent patients. The present analyses evaluated racial variation in cocaine use and addiction-related psychosocial outcomes at baseline and follow-up among 388 African American and White adults participating in 1 of 5 RCTs evaluating a range of pharmacological and behavioral treatments for cocaine use disorders. General linear modeling (GLM) indicated significant racial variation in cocaine and psychosocial indicators at baseline.

Strength in the midst of pain: Abuse as a predictor of sexual relationship power among substance-abusing Black women.

The aim of this research was to explore the association of abuse experiences (child sexual abuse and adult physical/sexual violence) to sexual relationship power among Black substance-abusing women. The study was a secondary analysis of baseline data collected from 124 Black women in 12 drug treatment programs across the United States who initially participated in an HIV risk reduction trial conducted within the National Drug Abuse Treatment Clinical Trials Network of the National Institute on Drug Abuse (NIDA). The findings revealed that adult sexual abuse, but not childhood sexual or adult physical abuse, was associated with lower relationship control and decision-making dominance as measured by the Sexual Relationship Power Scale.

Does change in readiness influence retention among African American women and men in substance abuse treatment?

African Americans are less likely than other racial groups to engage in and complete outpatient substance abuse treatment. The current study, conducted as a secondary analysis of a multisite randomized clinical trial, examined whether readiness to change (RTC) over time influences retention and whether gender moderates the relationship between changes in RTC and retention among 194 African American women and men. Participants completed the University of Rhode Island Change Assessment at baseline and at the end of the 16-week study.

Estimating Standardized Effect Sizes for Two- and Three-Level Partially Nested Data.

Although previous research has discussed an effect size estimator for partially nested cluster randomized designs, the existing estimator (a) is not efficient when used with primary data, (b) can be biased when the homogeneity of variance assumption is violated, and (c) has not yet been empirically evaluated for its finite sample properties. The present paper addresses these limitations by proposing an alternative maximum likelihood estimator for obtaining standardized mean difference effect size and the corresponding sampling variance for partially nested data, as well as the variants that do not make an assumption of homogeneity of variance. The typical estimator, denoted as d (d with pooled SD and d with control arm SD), requires input of summary statistics such as observed means, variances, and the intraclass correlation, and is useful for meta-analyses and secondary data analyses; the newly proposed estimator [Formula: see text] ([Formula: see text] and [Formula: see text]) takes parameter estimates from a correctly specified multilevel model as input and is mainly of interest to researchers doing primary research.

Pharmacological approaches to restoring lens transparency: Real world applications.

Cataract is the most common cause of blindness and a major cause of visual impairment worldwide. As the world's population ages, cataract-induced visual impairment is of increasing prevalence, and treatment is limited to those with access to surgical care. While cataracts are mainly a disease of the elderly, infantile cataracts lead to lifelong visual impairment if untreated.

The G protein Gαs acts as a tumor suppressor in sonic hedgehog signaling-driven tumorigenesis.

G protein-coupled receptors (GPCRs) are critical players in tumor growth and progression. The redundant roles of GPCRs in tumor development confound effective treatment; therefore, targeting a single common signaling component downstream of these receptors may be efficacious. GPCRs transmit signals through heterotrimeric G proteins composed of Gα and Gβγ subunits.

Poinsinet's Edition of the Naturalis historia (1771-1782) and the Revival of Pliny in the Sciences of the Enlightenment.

This paper analyses the revival of Pliny's Naturalis historia within the scientific culture of the late eighteenth and early nineteenth centuries, focusing on a French effort to produce an edition with annotations by scientists and scholars. Between the Renaissance and the early eighteenth century, the Naturalis historia had declined in scientific importance. Increasingly, it was relegated to the humanities, as we demonstrate with a review of editions.

The use of an ecodevelopmental approach to examining substance use among rural and urban Latino/a youth: peer, parental, and school influences.

Using an ecodevelopmental framework, we examined how peer, parent, and student variables influence substance (tobacco, alcohol, and marijuana) use among rural and urban Latino/a adolescents (N = 2,500). Generally speaking, Latino/a adolescents in rural areas endorsed higher levels of substance use. Among the primary variables of study, there were a number of nuanced differences noted based on location, gender, and type of substance.

How the hypothalamus controls glucose production: an update.

Recent evidence highlights a crucial role of the brain in the control of glucose homeostasis. The hypothalamus senses and integrates signals of fuel abundance, such as circulating macronutrients (glucose and fatty acids) and nutrient-induced hormones (insulin and leptin). This, in turn, results in the activation of neural pathways that return circulating nutrients to baseline by reducing hepatic glucose production and food intake.

Method for Evaluating Germicidal Ultraviolet Inactivation of Biocontaminated Surfaces.

Safety issues related to work-site conditions often deal with potential worker exposure to infectious airborne microorganisms due to their dissemination in indoor air and contamination of surfaces. Germicidal ultraviolet (GUV) radiation is used in health-care settings and other occupational environments for microbial inactivation. In this study, a new methodology for determining the efficiency of GUV microbial inactivation of surfaces was developed and evaluated.