Naming impairments evoked by focal cortical electrical stimulation in the ventral temporal cortex correlate with increased functional connectivity.

Background: High-frequency cortical electrical stimulations (HF-CES) are the gold standard for presurgical functional mapping. In the dominant ventral temporal cortex (VTC) HF-CES can elicit transient naming impairment (eloquent sites), defining a basal temporal language area (BTLA).

Objective: Whether naming impairments induced by HF-CES within the VTC are related to a specific pattern of connectivity of the BTLA within the temporal lobe remains unknown.

Out-of-bag Prediction Error: A Cross Validation Index for Generalized Structured Component Analysis.

Cross validation is a useful way of comparing predictive generalizability of theoretically plausible a priori models in structural equation modeling (SEM). A number of overall or local cross validation indices have been proposed for existing factor-based and component-based approaches to SEM, including covariance structure analysis and partial least squares path modeling. However, there is no such cross validation index available for generalized structured component analysis (GSCA) which is another component-based approach.

Decrease in American birth rates makes it imperative for the United States to implement state mandated fertility coverage.

In recent years, the prevalence of infertility has increased due to delayed childbearing and an increase in the rate of male infertility. Given the high cost of fertility treatment, this option is not valid for families with a low income, and those who can afford it usually choose to have multiple embryo transfer, which has led to an increase in multiple birth rates and an increase in the cost of perinatal care. Due to the expected increase in infertility and decrease in the national live birth rate, the US should set a plan to fund infertility treatment and lead a policy for single embryo transfer.

Investigational drugs for the treatment of Zika virus infection: a preclinical and clinical update.

Introduction: The Zika virus (ZIKV) infection results in severe neurological complications and has emerged as a threat to public health worldwide. No drugs or vaccines are available for use in the clinic and the need for novel and effective therapeutic agents is urgent.

Areas Covered: This review describes the latest progress of antiviral development for the treatment of ZIKV infection; it primarily focuses on the literature describing 20 potential anti-ZIKV drugs/agents currently being tested in vivo or in clinical trials.

Where are we with injectables against HIV infection and what are the remaining challenges?

Drug adherence has been a recurring issue in the field of HIV treatment, and low treatment adherence is typically associated with emergence of drug resistance, treatment failure and increased risks of transmission. Injectable antiretroviral drugs offer a unique opportunity to counter this issue for the treatment of HIV-positive individuals. In addition, injectables offer a remarkable opportunity to reduce new HIV infections, if applied in the context of both treatment-as-prevention and pre-exposure prophylaxis.

Hypnosis and Psychoanalysis: Toward Undoing Freud's Primal Category Mistake.

Hypnosis predates psychoanalysis, when autohypnotic pathologies were identified through the lens of hypnosis, and labeled "hypnoid hysteria" in the language of the day. The broad spectrum of disorders then subsumed under that term is still reflected in ICD-10's subset, "F44-Dissociative (Conversion) Disorders." Freud initially embraced both hypnoid hysteria and hypnosis, but came to abandon hypnosis and, by extension, hypnoid hysteria as well.

Creating and Sustaining a Culture of Excellence: Insights From Accomplished University Team-Sport Coaches.

Purpose: Winning several national championships is an extraordinary feat that very few university coaches have accomplished. The objective of this study was to investigate how some of Canada's most accomplished university team-sport coaches created and sustained a culture of excellence in their programs.

Method: Six university coaches who had won more than 30 national titles participated in this study.

Investigational HIV integrase inhibitors in phase I and phase II clinical trials.

To date, three HIV integrase strand transfer inhibitors (INSTIs), i.e. raltegravir, elvitegravir and dolutegravir, have been approved for clinical use.

Routine assessment of unmet needs in individuals with advanced cancer and their caregivers: A qualitative study of the palliative care needs assessment tool (PC-NAT).

Purpose: To examine (1) approaches used by oncologists to administer the palliative care needs assessment tool (PC-NAT) in consultations with patients with advanced cancer and their caregivers, (2) potential of this tool to facilitate discussion of psychosocial issues, and (3) whether use of the tool alters the length of consultations.

Design: A qualitative analysis was undertaken of audio-taped, outpatient consultations.

Sample And Methods: 20 individuals with advanced cancer and their caregivers who participated in an interrupted time series study of the impact of the systematic utilization of the PC-NAT had a total of 48 consultations audio-taped.

A comparison of socioeconomic status and mental health among inner-city Aboriginal and non-Aboriginal women.

Aboriginal women in urban areas have been reported to experience high rates of poverty, homelessness, interpersonal violence, and health problems. However, there are few prior ethnocultural comparisons of urban women from similar socioeconomic backgrounds. The current study explored the mental and physical health of Aboriginal and non-Aboriginal women accessing social services agencies and shelters.

The onset and progression of alcohol use disorders: A qualitative study from Goa, India.

Quantitative evidence about the burden of alcohol use disorders (AUDs) needs to be complemented with a nuanced qualitative understanding of explanatory models to help supplement public health strategies that are too often steeped uncritically in biomedical models. The aim of this study was to identify the role of various factors in the onset and persistence of AUD and recovery from AUD. This was a qualitative study nested in a population cohort from Goa, India.

A protocol for ovulation delay in women who cannot use estrogen, including Jewish women with Niddah issues and a pilot study.

Orthodox Jewish women abstain from sexual intercourse from the commencement of menstruation until seven days after the end of menstrual bleeding at which point they can immerse themselves in a ritual bath and recommence relations. For women who ovulate prior to commencing intercourse this results in religious infertility. The traditional treatment for religious infertility is oral estrogens in the early follicular phase to delay ovulation.

On Suggestibility and Placebo: A Follow-Up Study.

Identifying what makes some people respond well to placebos remains a major challenge. Here, we attempt to replicate an earlier study in which we found a relationship between hypnotic suggestibility and subjective ratings of relaxation following the ingestion of a placebo sedative (Sheiner, Lifshitz, & Raz, 2016). To assess the reliability of this effect, we tested 34 participants using a similar design.

Two-Way Regularized Fuzzy Clustering of Multiple Correspondence Analysis.

Multiple correspondence analysis (MCA) is a useful tool for investigating the interrelationships among dummy-coded categorical variables. MCA has been combined with clustering methods to examine whether there exist heterogeneous subclusters of a population, which exhibit cluster-level heterogeneity. These combined approaches aim to classify either observations only (one-way clustering of MCA) or both observations and variable categories (two-way clustering of MCA).

Positive penicillin allergy testing results: a systematic review and meta-analysis of papers published from 2010 through 2015.

β-lactam antibiotics are the most widely used group of antibiotics, given their effectiveness for the most common bacterial pathogens and their relatively low price. Adverse reactions, mainly cutaneous, are often reported to be associated with their use and hence, less effective and usually more costly alternative antibiotics are prescribed. However, it is not clear what is the risk of immediate immune-mediated (i.