89 results match your criteria: "a Guangzhou Women and Children's Medical Center affiliated to Guangzhou Medical University[Affiliation]"
CircFAM64A(3) promoted bladder cancer proliferation and inhibited CD8 + T cell via sponging to miR-149-5p and activated IL-6/JAK/STAT pathway.
Int Immunopharmacol
January 2025
Department of Urology, The First Affiliated Hospital of Nanjing Medical University China. Electronic address:
Background: The significance of circular RNA in tumour biology is increasingly recognized. This study aims to explore the value of circFAM64A(3) in the proliferation and immune evasion of bladder cancer.
Methods: Bioinformatics were used to identify the differentially expressed circular RNAs in bladder cancer.
Ziresovir in Hospitalized Infants with Respiratory Syncytial Virus Infection.
N Engl J Med
September 2024
From the Department of Respiratory Medicine (S.Z.), Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, National Clinical Research Center for Respiratory Diseases (S.Z., X.N.), National Center for Pediatric Cancer Surveillance, Key Laboratory of Major Diseases in Children, Ministry of Education (X.N), and the Department of Pediatric Medicine, Peking University Third Hospital (W.Z.), Beijing, the Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang (Y.S.), the Department of Pediatric Respiratory Medicine, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine (Y. Yin), the Department of Pulmonology, Shanghai Children's Hospital, and the School of Medicine, Shanghai Jiao Tong University (X.D.), and Shanghai Ark Biopharmaceutical (X.Z., T.J., Y.W., G.Z., K.R., J.Z.W.), Shanghai, the Department of Respiratory Medicine, Tianjin Children's Hospital, Machang Campus (Y. Zou), the Department of Respiratory Medicine, Tianjin Children's Hospital, Longyan Campus (Y.X.), and Tianjin University (Y. Zou, Y.X.), Tianjin, Children's Medical Center, Hunan Provincial People's Hospital, Changsha (L.Z.), the Departments of Respiratory Medicine and Pediatric Infectious Diseases, Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou (Hailin Zhang, Y.C.), the Department of Pediatrics, Sanya Central Hospital, Hainan Third People's Hospital, Sanya (Hua Zhang), the Department of Pediatric Respiratory Medicine, Children's Hospital of Nanjing Medical University (D.Z.), and the Department of Pediatric Medicine, First Affiliated Hospital with Nanjing Medical University (R.D.), Nanjing, the Department of Pediatrics, Women and Children's Hospital, and the School of Medicine, Xiamen University (T.S.), and the Department of Pediatric Respiratory Medicine, First Affiliated Hospital of Xiamen University (Y. Yang), Xiamen, the Department of Pediatrics, Zhongshan Women and Children's Hospital-Zhongshan Boai Hospital, Zhongshan (D.H.), the Department of Pediatric Respiratory Medicine, Jiangxi Provincial Children's Hospital, Nanchang (Q.C.), the Department of Pediatric Respiratory Medicine, Liaocheng People's Hospital, Liaocheng (Q.Y.), the Department of Respiratory Medicine and Clinical Allergy Center, Wuxi Children's Hospital, Wuxi (L.L.), the Department of Pediatric Respiratory Medicine, Children's Hospital, Zhejiang University School of Medicine, Hangzhou (Z.C.), the Department of Respiratory Medicine, Children's Hospital of Chongqing Medical University, Chongqing (E.L.), the Department of Pediatric Respiratory Medicine, Women and Children's Medical Center Affiliated to Guangzhou Medical University, Guangzhou (L.D., W.J.), the Department of Pediatric Respiration, Children's Medical Center, First Hospital of Jilin University, Changchun (H.C.), the Department of Pediatrics, First Affiliated Hospital of Guangxi Medical University, Nanning (G.N.), the Department of Pediatric Respiratory Medicine, Third Affiliated Hospital of Zhengzhou University (X.W.), and the Respiratory Department, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, and Zhengzhou Children's Hospital (Z.S.), Zhengzhou, the Department of Respiratory Medicine, Shenzhen Children's Hospital, Shenzhen (Y. Zheng), the Department of Respiratory Medicine, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan (X.L.), the Department of Respiratory Medicine, Children's Hospital of Soochow University, Suzhou (C.H.), and the Department of Pediatric Respiratory and Immunology Medicine, West China Second University Hospital, Sichuan University, Chengdu (H.L.) - all in China.
Background: Respiratory syncytial virus (RSV) is a leading cause of severe illness in infants, with no effective treatment. Results of a phase 2 trial suggested that ziresovir may have efficacy in the treatment of infants hospitalized with RSV infection.
Methods: In a phase 3, multicenter, double-blind, randomized, placebo-controlled trial conducted in China, we enrolled participants 1 to 24 months of age who were hospitalized with RSV infection.
Early Prenatal Detection of Recessive Split-hand/Foot Malformation Caused by a Homozygous Variant of .
J Med Ultrasound
August 2024
Prenatal Diagnostic Center, Guangzhou Women and Children's Medical Center Affiliated to Guangzhou Medical University, Guangzhou, Guangdong, China.
Role of indocyanine green-guided near-infrared fluorescence imaging in identification of the cause of neonatal cholestasis.
Medicine (Baltimore)
July 2024
Women and Children's Medical Center Affiliated to Guangzhou Medical University, Guangzhou, China.
Article Synopsis
- - The study investigated the use of indocyanine green (ICG)-guided near-infrared fluorescence (NIRF) imaging for diagnosing neonatal cholestasis during surgery, comparing its effectiveness to the traditional method of laparoscopic bile duct exploration from January to December 2022.
- - A total of 16 neonates, aged 42 to 93 days, were included, and while most (15 out of 16) were diagnosed with biliary atresia, the results from ICG-guided imaging matched those of laparoscopic exploration.
- - The findings indicate that ICG-guided NIRF is a safe and minimally invasive option with diagnostic reliability comparable to conventional methods, suggesting it could be a
The Association of Fetal Umbilical-portal-systemic Venous Shunts and Genetic Variants: Another Case Report.
J Med Ultrasound
February 2024
Prenatal Diagnostic Center, Guangzhou Women and Children's Medical Center Affiliated to Guangzhou Medical University, Guangzhou, Guangdong, China.
[Correlation between clinical phenotypes and genotypes among 46 children with SCN1A-related developmental epileptic encephalopathy].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
April 2024
Department of Neurology, Women and Children's Medical Center affiliated to Guangzhou Medical University, Guangzhou, Guangdong 510120, China.
Objective: To explore the correlation between clinical phenotypes and genotypes among 46 children with SCN1A-related developmental epileptic encephalopathy (DEE).
Methods: Clinical data of 46 children with DEE and SCN1A variants identified at the Guangzhou Women and Children's Medical Center between January 2018 and June 2022 were collected. The children were grouped based on their age of onset, clinical manifestations, neurodevelopmental status, and results of genetic testing.
Isolated polyhydramnios: Is a genetic evaluation of value?
Eur J Obstet Gynecol Reprod Biol
February 2024
Prenatal Diagnostic Center, Guangzhou Women and Children's Medical Center affiliated to Guangzhou Medical University, Guangzhou, Guangdong, China. Electronic address:
Objective: To analyze the risk for genetic aberrations and pregnancy outcomes in pregnancies with isolated polyhydramnios.
Study Design: This was a retrospective study of singleton pregnancies complicated by isolated polyhydramnios that underwent genetic amniocentesis between 2016 and 2021. Clinical and laboratory data were collected and reviewed for these cases, including maternal demographics, prenatal sonographic findings, chromosomal microarray results, and pregnancy outcomes.
Clinical and molecular analysis of nine fetal cases with clinically significant variants causing nemaline myopathy.
Eur J Obstet Gynecol Reprod Biol
January 2024
Prenatal Diagnostic Center, Guangzhou Women and Children's Medical Center affiliated to Guangzhou Medical University, Guangzhou, Guangdong, China. Electronic address:
Article Synopsis
- * It reviewed nine cases diagnosed with NM, identifying genetic mutations and analyzing ultrasound findings, where most had normal early scans but abnormalities in the second and third trimesters.
- * Of the nine cases studied, four pregnancies were terminated due to NM, while only one infant survived past one year, highlighting the challenges and serious implications of this condition.
A meta-analysis of treatment for early-stage cervical cancer: open versus minimally invasive radical trachelectomy.
BMC Pregnancy Childbirth
October 2023
Department of Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Background: In previous systematic reviews, meta-analysis was lacking, resulting in the statistical difference between the data of different surgeries being impossible to judge. This meta-analysis aims to contrast the fertility results and cancer outcomes between open and minimally invasive surgery.
Method: We systematically searched databases including PubMed, Embase, Cochrane, and Scopus to collect studies that included open and minimally invasive radical trachelectomy.
Application of real-time PCR-based multicolor melting curve with automatic analysis system in pregestational and prenatal thalassemia diagnoses.
Ann Hum Genet
November 2023
Prenatal Diagnostic Center, Guangzhou Women and Children's Medical Center affiliated to Guangzhou Medical University, Guangzhou, Guangdong, People's Republic of China.
Article Synopsis
- - The study assessed the effectiveness of a multicolor melting curve analysis (MMCA) for mass thalassemia screening and prenatal diagnosis using 18,912 blood samples from couples and prenatal sources.
- - MMCA showed a high detection rate for thalassemia genotypes, identifying various carriers and rare genetic variants, except for one specific initiation codon mutation.
- - The findings suggest that MMCA can be a reliable, cost-effective, and efficient alternative to traditional methods for thalassemia testing in routine screenings and prenatal diagnoses.
Association between serum copper level and reproductive health of Women in the United States: a cross-sectional study.
Int J Environ Health Res
June 2024
Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Copper is an indispensable trace element in metabolism. This study aimed to investigate the relationship between copper and reproductive health, and possibly provide new insights for diagnosis and treatment. This study was based on data extracted from the NHANES database (2013-2014 and 2015-2016).
View Article and Find Full Text PDFFetal macrocephaly in the third trimester: Prenatal phenotype of TAOK1-associated neurodevelopmental disorder.
Eur J Obstet Gynecol Reprod Biol
October 2023
Prenatal Diagnostic Center, Guangzhou Women and Children's Medical Center Affiliated to Guangzhou Medical University, Guangzhou, Guangdong, China. Electronic address:
[Analysis of a case of Multiple pterygium syndrome due to a novel variant of CHRNG gene].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
June 2023
Guangzhou Women and Children's Medical Center Affiliated to Guangzhou Medical University, Guangzhou, Guangdong 510630, China.
Objective: To explore the clinical characteristics and genetic etiology of a child with multiple pterygium syndrome (MPS).
Methods: A child with MPS who was treated at the Orthopedics Department of Guangzhou Women and Children's Medical Center Affiliated to Guangzhou Medical University on August 19, 2020 was selected as the study subject. Clinical data of the child was collected.
Autosomal recessive renal tubular dysgenesis: The need for clinical vigilance in anuric fetuses with normal renal sonography.
Eur J Obstet Gynecol Reprod Biol
June 2023
Prenatal Diagnostic Center, Guangzhou Women and Children's Medical Center affiliated to Guangzhou Medical University, Guangzhou, China. Electronic address:
Fetal phenotype of Cornelia de Lange syndrome with a molecular confirmation.
Eur J Obstet Gynecol Reprod Biol
May 2023
Prenatal Diagnostic Center, Guangzhou Women and Children's Medical Center Affiliated to Guangzhou Medical University, Guangzhou, Guangdong, China. Electronic address:
Article Synopsis
- The study aimed to showcase fetal features of Cornelia de Lange Syndrome (CdLS) through a review of 13 diagnosed cases using genetic testing and physical exams.
- All cases showed CdLS-causing genetic variants, with most linked to mutations in the NIPBL gene, while some had normal ultrasound results despite having the syndrome.
- Prenatal diagnoses are feasible for CdLS linked to NIPBL variants, but detecting non-classic cases solely through ultrasound remains difficult.
Accurate Identification of Breakpoints in a Cryptic Reciprocal Translocation by Whole-Genome Sequencing.
Cytogenet Genome Res
June 2023
Prenatal Diagnosis and Reproduction Department, Guangzhou Women and Children's Medical Center Affiliated to Guangzhou Medical University, Guangzhou, China.
Chromosomal abnormalities are a common cause of spontaneous abortions, but conventional detection methods (karyotype, FISH, and chromosomal microarray [CMA]) have limitations, and many cryptic balanced chromosomal rearrangements are difficult to detect. We describe a couple who experienced a missed abortion, studied by CMA. CMA of the abortion tissue detected a 1.
View Article and Find Full Text PDFFetal intrahepatic portosystemic shunts: A benign and self-limiting feature?
Eur J Obstet Gynecol Reprod Biol
April 2023
Prenatal Diagnostic Center, Guangzhou Women and Children's Medical Center affiliated to Guangzhou Medical University, Guangzhou, Guangdong, China. Electronic address:
Unexplained severe polyhydramnios: Remember Bartter syndrome.
Eur J Obstet Gynecol Reprod Biol
April 2023
Prenatal Diagnostic Center, Guangzhou Women and Children's Medical Center affiliated to Guangzhou Medical University, Guangzhou, China. Electronic address:
Long Non-Coding RNA TUG1 Attenuates Insulin Resistance in Mice with Gestational Diabetes Mellitus via Regulation of the MicroRNA-328-3p/SREBP-2/ERK Axis.
Diabetes Metab J
March 2023
Department of Obstetrics and Gynecology, Guangzhou Women and Children's Medical Center Affiliated to Guangzhou Medical University, Guangzhou, China.
Background: Long non-coding RNAs (lncRNAs) have been illustrated to contribute to the development of gestational diabetes mellitus (GDM). In the present study, we aimed to elucidate how lncRNA taurine upregulated gene 1 (TUG1) influences insulin resistance (IR) in a high-fat diet (HFD)-induced mouse model of GDM.
Methods: We initially developed a mouse model of HFD-induced GDM, from which islet tissues were collected for RNA and protein extraction.
Aicardi-Goutières syndrome: The need for clinical vigilance in fetuses with sonographic features of congenital infection.
Eur J Obstet Gynecol Reprod Biol
March 2023
Prenatal Diagnostic Center, Guangzhou Women and Children's Medical Center affiliated to Guangzhou Medical University, Guangzhou, China. Electronic address:
Retrospective analysis of prenatal ultrasound of children with Pompe disease.
Taiwan J Obstet Gynecol
November 2022
Prenatal Diagnostic Center, Guangzhou Women and Children's Medical Center Affiliated to Guangzhou Medical University, Guangzhou, Guangdong, China. Electronic address:
Objective: The aim of this retrospective study is to determine the prenatal ultrasound markers of patients diagnosed postnatally with infantile-onset Pompe disease (IOPD).
Materials And Methods: This is a retrospective study of cases with a postnatal diagnosis of IOPD during a 5-year period. The medical file of the patients with IOPD was reviewed, and data regarding especially pregnancy were collected.
Prenatal isolated clubfoot increases the risk for clinically significant exome sequencing results.
Prenat Diagn
December 2022
Prenatal Diagnostic Center, Guangzhou Women and Children's Medical Center Affiliated to Guangzhou Medical University, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou, Guangdong, China.
Article Synopsis
- The study aimed to assess the effectiveness of exome sequencing (ES) in identifying genetic causes of isolated fetal clubfoot in singleton pregnancies between 2018 and 2021.
- A total of 38 fetuses diagnosed with isolated clubfoot underwent ES after initial genetic testing was inconclusive, resulting in the identification of pathogenic variants in 10.5% of cases.
- The findings suggest that isolated clubfoot may be linked to genetic conditions, indicating that ES should be considered in genetic investigations for affected pregnancies.
Sotos syndrome: A study of antenatal presentation.
Eur J Obstet Gynecol Reprod Biol
December 2022
Prenatal Diagnostic Center, Guangzhou Women and Children's Medical Center Affiliated to Guangzhou Medical University, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou, Guangdong, People's Republic of China. Electronic address:
Objective: To determine the fetal ultrasound findings associated with Sotos syndrome caused by deletions at 5q35 including the NSD1 and a point mutation in this gene.
Study Design: This was a retrospective study of eight pregnancies with fetal Sotos syndrome identified by chromosomal microarray (CMA)/whole exome sequencing (WES). Clinical and laboratory data were collected and reviewed for these cases.
Outcomes associated with isolated agenesis of the corpus callosum diagnosed in utero.
Ultrasound Obstet Gynecol
October 2022
Prenatal Diagnostic Center, Guangzhou Women and Children's Medical Center affiliated to Guangzhou Medical University, Guangzhou, Guangdong, China.
First trimester megacystis caused by a homozygous variant in MYL9.
Eur J Obstet Gynecol Reprod Biol
November 2022
Prenatal Diagnostic Center, Guangzhou Women and Children's Medical Center affiliated to Guangzhou Medical University, Guangzhou, Guangdong, China. Electronic address: