5 results match your criteria: "a CReATe Fertility Centre[Affiliation]"
Ultrastructural identification of CD9 positive extracellular vesicles released from human embryos and transported through the zona pellucida.
Syst Biol Reprod Med
August 2019
a CReATe Fertility Centre, Toronto , Canada.
Extracellular vesicles (EVs) are highly specific and multi-purpose vesicular structures that are released by various cell and tissue types in the body. However, the secretion of EVs from mammalian embryos, especially human, has not been well characterized. Thus, the aim of this study was to 1) identify EVs in human preimplantation embryos at different stages of their development using scanning and electron microscopy, and 2) investigate whether EVs can cross the zona pellucida (ZP) and be released from human embryos cultured .
View Article and Find Full Text PDFInitial germ cell to somatic cell ratio impacts the efficiency of SSC expansion in vitro.
Syst Biol Reprod Med
February 2018
a CReATe Fertility Centre, Toronto , Ontario , Canada.
Unlabelled: Spermatogonial Stem Cell (SSC) expansion in vitro remains a major challenge in efforts to preserve fertility among pubertal cancer survivor boys. The current study focused on innovative approaches to optimize SSC expansion. Six- to eight-week-old CD-1 murine testicular samples were harvested by mechanical and enzymatic digestion.
View Article and Find Full Text PDFSperm DNA fragmentation index does not correlate with blastocyst euploidy rate in egg donor cycles.
Gynecol Endocrinol
March 2018
a CReATe Fertility Centre, Toronto , Canada.
Article Synopsis
- * The study included data from 45 IVF-ICSI cycles conducted at a fertility clinic, comparing those with a high DFI (greater than 15%) to those with a low DFI, revealing significant differences in sperm count and motility.
- * Despite differences in sperm quality, both groups showed similar rates of viable embryos (euploidy) after genetic screening, indicating that DFI did not significantly affect blastocyst euploidy in these IVF cycles.
The use of coenzyme Q10 and DHEA during IUI and IVF cycles in patients with decreased ovarian reserve.
Gynecol Endocrinol
July 2016
c Toronto West Fertility Center, Etobicoke , Canada .
Objective: The objective of this study is to compare the combination of dehydroepiandrosterone (DHEA) and coenzyme Q10 (CoQ10) (D + C) with DHEA alone (D) in intrauterine insemination (IUI) and in vitro fertilization (IVF) cycles among patients with decreased ovarian reserve.
Methods: We retrospectively extracted data from patients charts treated by DHEA with/without CoQ10 during IUI or IVF between February 2006 and June 2014. Prestimulation parameters included age, BMI, day 3 FSH and antral follicular count (AFC).
The continuum of high ovarian response: a rational approach to the management of high responder patient subgroups.
Syst Biol Reprod Med
September 2016
a CReATe Fertility Centre, Toronto , Ontario , Canada .
Article Synopsis
- Ovarian response to controlled ovarian hyperstimulation (COH) with gonadotropins varies significantly among patients and even within the same patient across different cycles.
- High responders, who react strongly to gonadotropins, face increased risks for ovarian hyperstimulation syndrome (OHSS), necessitating careful classification and management.
- The article reviews literature on high responders, proposes a clinical model to identify sub-groups, and suggests tailored treatment protocols to improve reproductive outcomes while minimizing complications.