9,335 results match your criteria: "a Bioprocessing Technology Institute; Centros[Affiliation]"

Synthesis of three-dimensional covalent organic frameworks through a symmetry reduction strategy.

Nat Chem

January 2025

State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, Jilin University, Changchun, People's Republic of China.

Three-dimensional (3D) covalent organic frameworks (COFs) hold significant promise for a variety of applications. However, conventional design approaches using regular building blocks limit the structural diversity of 3D COFs. Here we design and synthesize two 3D COFs, designated as JUC-644 and JUC-645, through a methodology that relies on using eight-connected building blocks with reduced symmetry.

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The gut-brain axis underlying hepatic encephalopathy in liver cirrhosis.

Nat Med

January 2025

Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China.

Up to 50-70% of patients with liver cirrhosis develop hepatic encephalopathy (HE), which is closely related to gut microbiota dysbiosis, with an unclear mechanism. Here, by constructing gut-brain modules to assess bacterial neurotoxins from metagenomic datasets, we found that phenylalanine decarboxylase (PDC) genes, mainly from Ruminococcus gnavus, increased approximately tenfold in patients with cirrhosis and higher in patients with HE. Cirrhotic, not healthy, mice colonized with R.

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The microalgal sector in Europe: Towards a sustainable bioeconomy.

N Biotechnol

January 2025

Research Division Agroecology and Environment, Agroscope, Zurich, Switzerland.

Microalgae are a diverse group of photosynthetic microorganisms that can be exploited to produce sustainable food and feed products, alleviate environmental pollution, or sequester CO to mitigate climate change, among other uses. To optimize resource use and integrate industrial waste streams, it is essential to consider factors such as the biology and cultivation parameters of the microalgal strains, as well as the cultivation system and processing technologies employed. This paper reviews the main commercial applications of microalgae (including cyanobacteria) and examines the biological and biotechnological aspects critical to the sustainable processing of microalgal biomass and its derived compounds.

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Local Symmetry-Broken Single Pd Atoms Induced by Doping Ag Sites for Selective Electrocatalytic Semihydrogenation of Alkynes.

ACS Nano

January 2025

Key Laboratory of Photoelectronic Conversion and Utilization of Solar Energy, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 260101, China.

Article Synopsis
  • Engineering the local coordination of single metal atoms can significantly boost their catalytic ability.
  • A study introduced Pd-Ag diatomic sites on g-CN, improving electrocatalytic semihydrogenation of alkynes compared to single Pd atom catalysts.
  • The asymmetric coordination from introducing Ag enhanced reaction efficiency, leading to over 98% conversion to styrene and a lower energy barrier for the reaction.
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Direct conversion of CO with renewable H to produce methanol provides a promising way for CO utilization and H storage. Cu/ZnO catalysts are active, but their activities depend on the preparation methods. Here, we reported a facile mechanical grinding method for the fast synthesis of Cu@zeolitic imidazolate framework-8 (ZIF-8) derived Cu/ZnO catalysts applied in CO hydrogenation to methanol.

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Aspergillus oryzae is a widely used host for heterologous expression of fungal natural products. However, the vectors previously developed are not convenient for use and screening positive transformants by PCR and fermentation is time- and effort-consuming. Hence, three plug-and-play vectors were developed here for multi-gene expression and liquid chromatography mass spectrometry detection was introduced to screen positive transformants.

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Revealing Intrinsic Free Charge Generation: Promoting the Construction of Over 19% Efficient Planar p-n Heterojunction Organic Solar Cells.

Angew Chem Int Ed Engl

January 2025

Key Laboratory of Photoelectric Conversion and Utilization of Solar Energy, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, 266101, China.

Due to high binding energy and extremely short diffusion distance of Frenkel excitons in common organic semiconductors at early stage, mechanism of interface charge transfer-mediated free carrier generation has dominated the development of bulk heterojunction (BHJ) organic solar cells (OSCs). However, considering the advancements in materials and device performance, it is necessary to reexamine the photoelectric conversion in current-stage efficient OSCs. Here, we propose that the conjugated materials with specific three-dimensional donor-acceptor conjugated packing potentially exhibit distinctive charge photogeneration mechanism, which spontaneously split Wannier-Mott excitons to free carriers in pure phases.

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Integrons in the Age of Antibiotic Resistance: Evolution, Mechanisms, and Environmental Implications: A Review.

Microorganisms

December 2024

State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bio-Resources, College of Life Science and Technology, Guangxi University, 100 Daxue Road, Nanning 530004, China.

Integrons, which are genetic components commonly found in bacteria, possess the remarkable capacity to capture gene cassettes, incorporate them into their structure, and thereby contribute to an increase in genomic complexity and phenotypic diversity. This adaptive mechanism allows integrons to play a significant role in acquiring, expressing, and spreading antibiotic resistance genes in the modern age. To assess the current challenges posed by integrons, it is necessary to have a thorough understanding of their characteristics.

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Naturally occurring protein toxins can derive from bacteria, fungi, plants, and animal venom. Traditionally, toxins are known for their destructive effects on host cells. Despite, and sometimes even because of, these harmful effects, toxins have been used for medical benefits.

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In the modern world, the principles of the bioeconomy are becoming increasingly important. Recycling and reusability play a crucial role in sustainable development. Green chemistry is based on enzymes, but immobilized biocatalysts are still often designed with synthetic polymers.

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Article Synopsis
  • The widespread presence of pharmaceuticals and personal care products (PPCPs) in the environment is a major concern due to their potential harmful effects on human health and wildlife.
  • Research highlights the role of various microorganisms, including algae, bacteria, and fungi, in biodegrading pharmaceutical compounds, with new techniques like Bio Electrochemical Systems (BES) being explored for enhanced degradation in wastewater.
  • Genetic modification of microbial strains is being evaluated to boost their degradation capabilities, while environmental factors such as temperature and pH may influence overall bioremediation efficiency, highlighting a need for further research in this area.
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Recent advances in phytase thermostability engineering towards potential application in the food and feed sectors.

Food Sci Biotechnol

January 2025

Integrated Bioprocess Laboratory, Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur, Chennai, 603203 India.

Article Synopsis
  • This review highlights recent advancements in engineering thermostable phytase through genetic modification and immobilization techniques over the last seven years.
  • Genetic modifications have improved the enzyme's thermostability and functionality, while immobilization methods have helped retain 50-60% of its activity at temperatures above 50°C.
  • Phytase is essential in the food and feed industries, as it reduces phytate content to enhance nutritional value in flour and poultry feed, making it a robust option for high-temperature applications.
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Given the complexities of continuous bioprocessing, it is critical to thoroughly investigate the process parameters unique to multi-column chromatography (MCC) and their potential impacts. However, existing studies have focused on either loading densities or residence time at steady states only, and their combined impact on critical quality attributes (CQAs) especially during transient phases were less known. In this study, we investigated the impact of critical process parameters during both steady-state and transient phases (start-up, close-down, and intermediate perturbation) through full factorial design.

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The purpose of this review is to gain attention about intro the advanced and green technology that has dual action for both clean wastewater and produce energy. Water scarcity and the continuous energy crisis have arisen as major worldwide concerns, requiring the creation of ecologically friendly and sustainable energy alternatives. The rapid exhaustion of fossil resources needs the development of alternative energy sources that reduce carbon emissions while maintaining ecological balance.

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Membrane-assisted direct seawater splitting (DSS) technologies are actively studied as a promising route to produce green hydrogen (H), whereas the indispensable use of supporting electrolytes that help to extract water and provide electrochemically-accelerated reaction media results in a severe energy penalty, consuming up to 12.5 % of energy input when using a typical KOH electrolyte. We bypass this issue by designing a zero-gap electrolyzer configuration based on the integration of cation exchange membrane and bipolar membrane assemblies, which protects stable DSS operation against the precipitates and corrosion in the absence of additional supporting electrolytes.

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Effect of catalase on CPC production during fermentation of Acremonium chrysogenum.

Bioresour Bioprocess

January 2025

Qingdao Innovation Institute of East China University of Science and Technology, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, People's Republic of China.

Cephalosporin C (CPC) is a critical raw material for cephalosporin antibiotics produced by Acremonium chrysogenum. During fermentation, the oxygen supply is a crucial factor limiting the efficient biosynthesis of CPC. This study demonstrated that the addition of exogenous surfactants significantly increased the dissolved oxygen (DO) level, extracellular catalase content, and final CPC titer.

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For commercial viability, cultivated meats require scientifically informed approaches to identify and manage hazards and risks. Here we discuss food safety in the rapidly developing field of cultivated meat as it shifts from lab-based to commercial scales. We focus on what science-informed risk mitigation processes can be implemented from neighbouring fields.

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Evaluating grease trap management practices: A case study from Seri Kembangan, Malaysia.

J Environ Manage

January 2025

Department of Food Service and Management, Faculty of Food Science and Technology, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia; Laboratory of Food Safety and Food Integrity Institute of Tropical Agriculture and Food Security, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. Electronic address:

Sewerage blockages due to oil and grease deposition discharged from food premises remain a persistent issue globally. This study evaluates the degree of compliance of food premises in Seri Kembangan, Selangor, Malaysia with grease trap guideline, and investigates the factors affecting restaurants' compliance performance. Data were collected from 36 restaurants through a questionnaire-based interview consisting of questions about grease trap installation, operation, maintenance and waste disposal, followed by a walkthrough of the kitchen.

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Combination of Apigenin and Melatonin with nanostructured lipid carriers as anti-inflammatory ocular treatment.

Int J Pharm

December 2024

Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028, Barcelona, Spain; Institute of Nanoscience and Nanotechnology (IN(2)UB), University of Barcelona, 08028 Barcelona, Spain. Electronic address:

Ocular inflammation is a complex pathology with limited treatment options. While traditional therapies have side effects, novel approaches, such as natural compounds like Apigenin (APG) and Melatonin (MEL) offer promising solutions. APG and MEL, in combination with nanostructured lipid carriers (NLC), may provide a synergistic effect in treating ocular inflammation, potentially improving patient outcomes and reducing adverse effects.

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Efficient separation and preconcentration of nanoparticles are crucial in a wide range of biomedical applications, particularly as target substances continue to diminish in size. In this study, we introduce an electric field-assisted membrane system that synergistically combines oversized-pore membranes with an electrokinetic particle retention mechanism. Utilizing Ti/Au-coated poly(tetrafluoroethylene) (PTFE) membranes, our approach generates electrokinetic forces to effectively separate and retain charged nanoparticles even smaller than the pores, achieving a separation efficiency over 99% and a preconcentration factor of 1.

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Multifunctional ortho-quinones are required for the formation of thiol-catechol-connectivities (TCC) but can be delicate to handle. We present the electrochemical oxidation of the dipeptide DiDOPA, achieving up to 92 % conversion efficiency of the catechols to ortho-quinones. Graphite and stainless steel could be employed as cost-efficient electrodes.

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Microwave-assisted protein extraction from foxtail millet: Optimization, structural characterization, techno-functional properties, and bioactivity of peptides.

Int J Biol Macromol

December 2024

Food Engineering and Bioprocess Technology Program, Department of Food, Agriculture, and Bioresources, School of Environment, Resources, and Development, Asian Institute of Technology, Khlong Luang, Pathumthani 12120, Thailand. Electronic address:

This research investigates the impact of microwave power, processing time, and solid-to-solvent ratio on protein recovery from foxtail millet (Setaria italica), using an artificial neural network (ANN) and genetic algorithm (GA). The extracted protein and subsequent hydrolysates were also evaluated for their techno-functional, structural, and digestibility properties. The ANN model, trained with the Levenberg-Marquardt algorithm and optimized by a GA, identified optimal extraction conditions (960 W, 66.

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Thermal processes are emerging as promising solutions to recovering phosphorus and other nutrient elements from anaerobic digestates. The feasibility of nutrient element recovery depends largely on the fates of nutrient elements and heavy metals during thermal processing. This study assesses the partitioning of macronutrients (N, P, K, Na, Ca and Mg) and heavy metals (Zn, Cu, and Mn) between condensed and gaseous phases during thermal conversion of cattle slurry digestates in gas atmospheres of pyrolysis, combustion, and gasification processes.

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A comprehensive understanding of microbial community dynamics is fundamental to the advancement of environmental microbiology, human health, and biotechnology. Metaproteomics, defined as the analysis of all proteins present within a microbial community, provides insights into these complex systems. Microbial adaptation and activity depend to an important extent on newly synthesized proteins (nP), however, the distinction between nP and bulk proteins is challenging.

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Metabolic Engineering of Corynebacterium glutamicum for High-Level Production of 1,5-Pentanediol, a C5 Diol Platform Chemical.

Adv Sci (Weinh)

December 2024

Department of Chemical Engineering and Materials Science, Graduate Program in System Health Science and Engineering, Ewha Womans University, Seoul, 03760, Republic of Korea.

The biobased production of chemicals is essential for advancing a sustainable chemical industry. 1,5-Pentanediol (1,5-PDO), a five-carbon diol with considerable industrial relevance, has shown limited microbial production efficiency until now. This study presents the development and optimization of a microbial system to produce 1,5-PDO from glucose in Corynebacterium glutamicum via the l-lysine-derived pathway.

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