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TLR4 polymorphism and periodontitis susceptibility: A meta-analysis.

Medicine (Baltimore)

September 2016

Stomatological Hospital Affiliated to Zunyi Medical College School of Stomatology, Zunyi Medical University Special Key Laboratory of Oral Diseases Research, Higher Education Institution, Zunyi, Guizhou Province, China.

Background: Many primary and secondary studies reported the association between Toll-like receptor 4 (TLR4) polymorphism and periodontitis susceptibility, which mainly focused on TLR4-299A>G or TLR4-399C>T of Caucasian, however, these studies had different conclusions. The aim of this study was to reassess relative studies about TLR4 polymorphism and periodontitis susceptibility, and update meta-analysis.

Methods: We searched the electronic database including CNKI (Chinese National Knowledge Infrastructure), PubMed, Embase, and hand searched relative studies until January 4, 2016.

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