30 results match your criteria: "Zuckerberg San Francisco General Hospital and the University of California[Affiliation]"

Alterations in platelet behavior after major trauma: adaptive or maladaptive?

Platelets

April 2021

Pittsburgh Trauma Research Center and Division of Trauma and Acute Care Surgery, University of Pittsburgh, Pittsburgh, PA, USA.

Platelets are damage sentinels of the intravascular compartment, initiating and coordinating the primary response to tissue injury. Severe trauma and hemorrhage induce profound alterations in platelet behavior. During the acute post-injury phase, platelets develop a state of impaired agonist responsiveness independent of platelet count, associated with systemic coagulopathy and mortality risk.

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Predictors of postinjury acute respiratory distress syndrome: Lung injury persists in the era of hemostatic resuscitation.

J Trauma Acute Care Surg

August 2019

From the Department of Surgery (L.Z.K., A.J.R., A.S.C., B.J.R., B.M.H., M.F.N.), Zuckerberg San Francisco General Hospital and the University of California, San Francisco, San Francisco, California; Department of Medicine (C.M.H., C.S.C.), University of California, San Francisco, San Francisco, California; Department of Biostatistics (S.M.), University of California, Berkeley, Berkeley, California; and Department of Surgery (M.J.C.), Denver Health Medical Center and the University of Colorado, Denver, Colorado.

Article Synopsis
  • The study investigates predictors of acute respiratory distress syndrome (ARDS) in trauma patients post-injury, particularly looking at the effects of hemostatic resuscitation practices over a span from 2005 to 2016.
  • Out of 914 intubated trauma patients, 22% developed ARDS, with early diagnoses typically occurring within 24 hours and a correlation found between severity of injuries and later diagnoses.
  • Platelet transfusion was identified as an independent risk factor for developing ARDS, while blood and plasma transfusions showed no significant relationship, suggesting a need for further exploration into the role of platelets in lung injury.
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Latently-infected CD4+ T cells are widely considered to be the major barrier to a cure for HIV. Much of our understanding of HIV latency comes from latency models and blood cells, but most HIV-infected cells reside in lymphoid tissues such as the gut. We hypothesized that tissue-specific environments may impact the mechanisms that govern HIV expression.

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Perhaps it's not the platelet: Ristocetin uncovers the potential role of von Willebrand factor in impaired platelet aggregation following traumatic brain injury.

J Trauma Acute Care Surg

November 2018

From the Department of Surgery (L.Z.K, A.J.R., A.S.C., A.T.F., R.A.C.,), Zuckerberg San Francisco General Hospital and the University of California, San Francisco, San Francisco, California; Department of Medicine (C.M.H., C.S.C.), San Francisco General Hospital and the University of California, San Francisco, San Francisco, California; and Department of Surgery (M.J.C.), Denver Health Medical Center and the University of Colorado; Denver, Colorado.

Background: Injury to the blood-brain barrier exposes endothelium rich in von Willebrand factor (vWF), which may play a role in altered platelet aggregation following traumatic brain injury (TBI). Ristocetin is an antimicrobial substance that induces vWF-mediated aggregation of platelets. We examined these mechanisms in injured patients by measuring the aggregation response of platelets to stimulating agonists (including ristocetin) via whole-blood multiple-electrode platelet aggregometry.

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