30 results match your criteria: "Zuckerberg San Francisco General Hospital and the University of California[Affiliation]"
Platelets
April 2021
Pittsburgh Trauma Research Center and Division of Trauma and Acute Care Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Platelets are damage sentinels of the intravascular compartment, initiating and coordinating the primary response to tissue injury. Severe trauma and hemorrhage induce profound alterations in platelet behavior. During the acute post-injury phase, platelets develop a state of impaired agonist responsiveness independent of platelet count, associated with systemic coagulopathy and mortality risk.
View Article and Find Full Text PDFJ Thromb Haemost
September 2019
Department of Surgery, Denver Health Medical Center and the University of Colorado, Denver, Colorado.
J Trauma Acute Care Surg
August 2019
From the Department of Surgery (L.Z.K., A.J.R., A.S.C., B.J.R., B.M.H., M.F.N.), Zuckerberg San Francisco General Hospital and the University of California, San Francisco, San Francisco, California; Department of Medicine (C.M.H., C.S.C.), University of California, San Francisco, San Francisco, California; Department of Biostatistics (S.M.), University of California, Berkeley, Berkeley, California; and Department of Surgery (M.J.C.), Denver Health Medical Center and the University of Colorado, Denver, Colorado.
PLoS Pathog
November 2018
San Francisco Veterans Affairs (VA) Medical Center and University of California, San Francisco (UCSF), San Francisco, CA, United States of America.
Latently-infected CD4+ T cells are widely considered to be the major barrier to a cure for HIV. Much of our understanding of HIV latency comes from latency models and blood cells, but most HIV-infected cells reside in lymphoid tissues such as the gut. We hypothesized that tissue-specific environments may impact the mechanisms that govern HIV expression.
View Article and Find Full Text PDFJ Trauma Acute Care Surg
November 2018
From the Department of Surgery (L.Z.K, A.J.R., A.S.C., A.T.F., R.A.C.,), Zuckerberg San Francisco General Hospital and the University of California, San Francisco, San Francisco, California; Department of Medicine (C.M.H., C.S.C.), San Francisco General Hospital and the University of California, San Francisco, San Francisco, California; and Department of Surgery (M.J.C.), Denver Health Medical Center and the University of Colorado; Denver, Colorado.
Background: Injury to the blood-brain barrier exposes endothelium rich in von Willebrand factor (vWF), which may play a role in altered platelet aggregation following traumatic brain injury (TBI). Ristocetin is an antimicrobial substance that induces vWF-mediated aggregation of platelets. We examined these mechanisms in injured patients by measuring the aggregation response of platelets to stimulating agonists (including ristocetin) via whole-blood multiple-electrode platelet aggregometry.
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