2 results match your criteria: "Zoucheng Hospital of Traditional Chinese Medicine[Affiliation]"
EZH2 regulates H2B phosphorylation and elevates colon cancer cell autophagy.
J Cell Physiol
February 2020
Department of Gastrointestinal Surgery, Jining No. 1 People's Hospital, Jining, China.
Epigenetic alterations, especially histone modification, play vital roles in the pathogenesis of colon cancer. Upregulation of the enhancer of zeste homolog 2 (EZH2) has been reported to contribute to the initiation and progression of colon cancer. This study analyzed the association between EZH2 and phosphorylation of H2B at tyrosine 37 (H2B ) in colon cancer tissues and cells, along with the influences of the EZH2-H2B axis on colon cancer cell autophagy.
View Article and Find Full Text PDFEffect of Long Noncoding RNA H19 Overexpression on Intestinal Barrier Function and Its Potential Role in the Pathogenesis of Ulcerative Colitis.
Inflamm Bowel Dis
November 2016
*Division of General Surgery, Peking University First Hospital, Peking University, Beijing, People's Republic of China; and †Division of Gastroenterology, Zoucheng Hospital of Traditional Chinese Medicine, Zoucheng, People's Republic of China.
Background: Recently, long noncoding RNA (lncRNA) H19 has been reported to be related with VDR signaling and the development of inflammatory diseases including osteoarthritis. The aim of this study was to investigate the correlation between the expression level of H19 and VDR in ulcerative colitis (UC) tissues and to investigate the effect of H19 overexpression on intestinal epithelial barrier function.
Methods: The expression level of H19, miR-675-5p, and VDR in UC tissues and paired normal tissues collected from 12 patients with UC was investigated by quantitative real-time polymerase chain reaction.