3,676 results match your criteria: "Zollinger-Ellison Syndrome"
First reported case of multiple endocrine neoplasia type 1 in an Australian Aboriginal.
Endocrinol Diabetes Metab Case Rep
July 2024
Alice Springs Hospital, Alice Springs, Northern Territory, Australia.
Article Synopsis
- - The case study discusses a 48-year-old Aboriginal Australian woman diagnosed with Multiple Endocrine Neoplasia type 1 (MEN1), who faced significant health issues including hypercalcaemia, following a history of parathyroid surgery and several severe medical conditions, indicating the complexity of her case.
- - Genetic testing revealed a rare variant in the MEN1 gene, but cultural and logistical challenges hindered effective genetic counseling for her family, highlighting gaps in healthcare support for remote Aboriginal communities.
- - The case underscores the critical need for improved genetic counseling approaches and timely recognition of rare diseases in remote areas, as late diagnoses can lead to severe health consequences, as seen in her unfortunate passing in 2021.
Long-Term Proton Pump Inhibitor-Acid Suppressive Treatment Can Cause Vitamin B Deficiency in Zollinger-Ellison Syndrome (ZES) Patients.
Int J Mol Sci
July 2024
Digestive Diseases Branch, NIDDK, NIH, Bethesda, MD 20892-1804, USA.
Article Synopsis
- * A study of 175 ZES patients showed that 21% had vitamin B deficiency after an average of 10.2 years of treatment, particularly correlating with extremely low acid control rates.
- * The findings indicate that chronic PPI use results in significant acid reduction, which negatively impacts vitamin B levels and body stores, increasing the risk of deficiency.
Presentation, Diagnosis, and Treatment of a Sporadic Gastrinoma With Liver Metastases.
Cureus
May 2024
General Surgery, Brookdale University Hospital Medical Center, Brooklyn, USA.
Article Synopsis
- - A gastrinoma is a rare but serious tumor that produces gastrin, which can cause symptoms like anemia, weight loss, and diarrhea, complicating early detection.
- - These tumors often spread to the liver, and surgery is typically necessary to remove both the primary tumor and any metastases for a chance at a cure.
- - This report discusses a case involving a 59-year-old woman with anemia and gastrointestinal bleeding, revealing a pancreatic gastrinoma with extensive liver metastases, along with the treatment approach taken to improve her survival odds.
Natural language processing assisted detection of inappropriate proton pump inhibitor use in adult hospitalised patients.
Eur J Hosp Pharm
June 2024
Department of Electronic Engineering, Tsinghua University, Beijing, China
Article Synopsis
- The study aimed to create a system (PPI-MS) that monitors the clinical use of proton pump inhibitors (PPIs) in hospitalized adults, enhancing the detection of inappropriate usage.
- Researchers used natural language processing to analyze patient records and identify both therapeutic and preventive applications of PPIs, reviewing 9421 cases from July 2022 to July 2023.
- Results showed that over 50% of PPIs were used for prophylaxis, with nearly half deemed inappropriate, mainly due to lack of indications, and the monitoring system demonstrated a high accuracy and efficiency compared to manual tracking methods.
Middle-segment preserving pancreatectomy: a literature review and case report.
Langenbecks Arch Surg
June 2024
Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan.
Article Synopsis
- Middle segment-preserving pancreatectomy (MSPP) is a newer surgical option for treating benign and borderline pancreatic diseases, offering an alternative to total pancreatectomy (TP), with only 36 reported cases so far.
- In a case study of a 49-year-old man with Zollinger-Elison syndrome, MSPP was successfully performed, resulting in a postoperative pancreatic fistula that improved with conservative care, and no tumor recurrence was observed.
- Although MSPP has a high morbidity rate (54%) primarily due to complications like pancreatic fistula, it shows low mortality rates and maintains pancreatic function similar to traditional surgeries.
Article Synopsis
- A 5-year-old neutered Somali cat had jaundice due to extrahepatic biliary obstruction caused by a mass in the common bile duct, which was diagnosed as neuroendocrine carcinoma.
- During surgery, a perforation in the duodenum was also found, leading to the combined surgical procedures of choledochoduodenostomy and Billroth II.
- Although the cat recovered and survived for nearly 100 days without recurrence of the initial issues, it continued to experience intermittent vomiting and weight loss, indicating poor quality of life despite treatment.
Gastric neuroendocrine neoplasms.
Nat Rev Dis Primers
April 2024
Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum - University of Bologna, Bologna, Italy.
Article Synopsis
- Gastric neuroendocrine neoplasms (gNENs), including gastric neuroendocrine carcinomas (gNECs) and gastric neuroendocrine tumors (gNETs), are on the rise and have unique features compared to other neuroendocrine neoplasms.
- gNETs are classified into three types: Type I and II are gastrin-dependent and linked to chronic conditions, while Type III is sporadic with no hypergastrinaemia; each type has distinct clinical characteristics and treatment approaches.
- Management varies significantly, with Type I typically treated through endoscopy or surgery, Type II depending on multiple endocrine neoplasia type 1 management, and Type III requiring both local and systemic therapies,
Severe Hypomagnesemia Caused by Proton-Pump Inhibitors in a Patient With an Ostomy.
Cureus
March 2024
Nephrology, University of Florida College of Medicine - Jacksonville, Jacksonville, USA.
Article Synopsis
- * Long-term PPI use has been linked to electrolyte imbalances, particularly hypomagnesemia, but also hypokalemia and hypocalcemia, which may result from gastrointestinal or renal losses.
- * A case study highlights a patient with severe hypomagnesemia due to PPI use combined with gastrointestinal losses, leading to serious symptoms like tetany and arrhythmias.
Recurrent Duodenal Ulceration-More Than Simple Peptic Ulcer Disease?
Gastroenterology
September 2024
Division of Hospital Medicine, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina.
Sporadic gastrinoma with refractory benign esophageal stricture: A case report.
World J Clin Cases
March 2024
Department of Gastroenterology, First Affiliated Hospital of Anhui Medical University, Hefei 230001, Anhui Province, China.
Article Synopsis
- - Gastrinoma leads to excess gastrin production, resulting in increased gastric acid and recurring health issues like peptic ulcers and chronic diarrhea, coupled with complications such as esophageal strictures.
- - A case study illustrates a patient with gastrinoma who faced refractory benign esophageal stricture (RBES) and complete esophageal blockage, despite various treatments aimed at reducing acid secretion.
- - Early diagnosis of gastrinoma is crucial; prolonged uncontrolled acid can significantly heighten the risk of severe esophageal strictures, making treatment options like endoscopic procedures risky and complex.
Sporadic Zollinger-Ellison syndrome in a patient with isolated mesenteric gastrinoma.
Int J Surg Case Rep
March 2024
Faculté des Sciences de la Santé, Université Abdou Moumouni, Niamey, Niger.
Article Synopsis
- * A 40-year-old patient with long-term epigastric pain and diarrhea was diagnosed with ZES after undergoing imaging and biopsy, revealing a gastrinoma.
- * Surgical removal of the gastrinoma is the most effective treatment for ZES, and early diagnosis is crucial for managing symptoms like chronic diarrhea and abdominal pain.
Article Synopsis
- A 54-year-old man with obesity, hypertension, and a long history of abdominal pain underwent various medical tests over 12 years, revealing multiple ulcers but no clear diagnosis initially.
- In 2022, he was diagnosed with gastrinoma, a type of neuroendocrine tumor, after advanced imaging techniques identified a lesion not visible on CT scans.
- The report emphasizes the need to consider neuroendocrine tumors in similar cases and supports using 68Ga-DOTATOC PET/CT scans over older imaging methods for accurate diagnosis.
Primary gastrinoma of the gallbladder: a case report and review of the literature.
Front Oncol
January 2024
Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing, China.
Article Synopsis
- Primary gallbladder gastrinoma is a rarely reported neuroendocrine tumor, with no known prior cases documented in medical literature.
- A case study details a 50-year-old woman who experienced watery diarrhea and was later diagnosed with a tumor located at the gallbladder neck, confirmed during laparoscopic surgery.
- The study emphasizes the importance of immunohistochemical analysis for diagnosis and suggests that surgical removal can successfully alleviate symptoms, contributing new insights into this uncommon condition.
The cckOMA syndrome and its relation to the Zollinger-Ellison syndrome: a diagnostic challenge.
Scand J Gastroenterol
May 2024
Department of Clinical Biochemistry, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark.
Article Synopsis
- * The review highlights the need for gastroenterologists to recognize the symptoms of CCKoma, which can overlap with Zollinger-Ellison syndrome, and discusses the importance of accurate CCK and gastrin testing for proper diagnosis.
- * There is a notable lack of clinical awareness regarding CCKoma syndrome, as well as misconceptions about the specificity required for diagnostic assays, hindering accurate diagnosis and treatment for affected patients
Chronic Use of Proton Pump Inhibitors: A Potential Link to Amino Acid Deficiency and the Development of Depression.
Cureus
December 2023
Department of Behavioral Medicine and Psychiatry, West Virginia University School of Medicine, Martinsburg, USA.
Article Synopsis
- * A 34-year-old woman with long-term GERD treated with proton pump inhibitors (PPIs) experienced depression, which was later discovered to be due to a severe deficiency in the amino acid tyrosine.
- * After discontinuing PPIs and supplementing tyrosine, her depressive symptoms improved significantly, highlighting a potential connection between PPI use and mood disorders.
PBPK modeling to predict the pharmacokinetics of pantoprazole in different CYP2C19 genotypes.
Arch Pharm Res
January 2024
College of Pharmacy, Dongguk University-Seoul, Goyang, 10326, Republic of Korea.
Article Synopsis
- Pantoprazole is a medication used for treating GERD, maintaining esophagitis healing, and managing Zollinger-Ellison syndrome symptoms.
- It is primarily metabolized by the enzyme CYP2C19, which varies genetically among individuals, affecting how the drug is processed in the body.
- This study established a physiologically based pharmacokinetic model to predict pantoprazole's effects across different CYP2C19 enzyme activities, finding that the model accurately reflected observed clinical data, paving the way for more personalized treatment approaches.
Severe esophageal stricture after perforation and necrotizing esophagitis: unusual presentation of a duodenal gastrinoma.
J Surg Case Rep
December 2023
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601, Japan.
Article Synopsis
- Gastrinomas are rare tumors in the pancreas or duodenum that produce excess gastrin, leading to serious gastrointestinal issues such as gastroesophageal reflux disease, peptic ulcers, and chronic diarrhea.
- A case study of a 58-year-old woman reveals that her duodenal gastrinoma resulted in severe complications, including esophageal perforation and stricture, highlighting the tumor's potential seriousness.
- Early diagnosis of gastrinomas is crucial to prevent severe outcomes, suggesting that patients with persistent gastroesophageal reflux disease should be screened for this condition, especially if they require long-term treatment.
Management of Gastric Neuroendocrine Tumors: A Review.
Ann Surg Oncol
March 2024
Division of Surgical Oncology, Department of Surgery, Emory University School of Medicine, Atlanta, GA, USA.
Article Synopsis
- - Gastric neuroendocrine tumors (G-NET) are uncommon tumors from gastric enterochromaffin-like cells, classified into low, intermediate, or high grades based on their growth rates and further divided into three subtypes.
- - Types 1 and 2 tumors have elevated serum gastrin levels, often present with symptoms like abdominal pain and diarrhea, and are usually multifocal, while Type 3 tumors have normal gastrin levels, are solitary, and more aggressive.
- - Treatment and outcomes vary based on the tumor type, size, and stage, with Type 1 having the best prognosis and Type 3 the worst; the review covers their symptoms, diagnosis, and surgical options.
Complete Esophageal Obstruction: A Rare Complication of Zollinger-Ellison Syndrome.
ACG Case Rep J
November 2023
Section on Gastroenterology and Hepatology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC.
Article Synopsis
- Complete esophageal obstruction (CEO) is uncommon and often occurs in patients who have undergone radiation in the head and neck area.
- Zollinger-Ellison syndrome (ZES) usually involves little esophageal damage due to effective medications, and no previous cases of CEO in ZES patients have been reported.
- This case highlights the possible complications faced by modern patients with ZES, noting the lack of established endoscopic treatment options for such rare instances.
Esophageal Perforation Unveiling the Diagnosis of Zollinger-Ellison Syndrome.
J Community Hosp Intern Med Perspect
September 2023
Division of Gastroenterology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, United States.
Article Synopsis
- Gastrinomas, the most common neuroendocrine tumors, lead to Zollinger-Ellison Syndrome (ZES), characterized by high gastrin levels that cause increased acid production and symptoms like abdominal pain and diarrhea.
- *Despite symptoms resembling other conditions like GERD, delayed diagnosis can occur, as illustrated in a patient who had a history of GERD and a gastric ulcer but continued to suffer from severe symptoms.
- *The case highlights the need for early detection of ZES through serum gastrin testing to prevent serious complications like gastric perforation and metastasis, noting that esophageal perforation is atypical for ZES but possible due to persistent vomiting.
Multiple endocrine neoplasia type 1 with Zollinger-Ellison syndrome: clinicopathological analysis of a Japanese family with focus on menin immunohistochemistry.
Front Endocrinol (Lausanne)
December 2023
Department of Surgery, National Hospital Organization Hakodate Hospital, Hakodate, Hokkaido, Japan.
Article Synopsis
- MEN1 is a genetic disorder that leads to multiple tumors in various organs, caused by mutations in the menin gene; this study focused on a Japanese family with MEN1 and Zollinger-Ellison syndrome (ZES).
- The family members exhibited several tumors, including NETs and other types, and their treatment outcomes highlighted the importance of pancreaticoduodenectomy for ZES management.
- The results indicated that long-term monitoring is critical for pulmonary NETs due to the risk of metastasis, and variations in menin immunohistochemistry might reflect tumor development rather than serving as a reliable diagnostic marker.
AGA Clinical Practice Update on the Epidemiology, Evaluation, and Management of Exocrine Pancreatic Insufficiency: Expert Review.
Gastroenterology
November 2023
Division of Gastroenterology, Hepatology, and Nutrition, University of Florida, Gainesville, Florida.
Article Synopsis
- Exocrine pancreatic insufficiency (EPI) is a condition where the pancreas fails to provide enough digestive enzymes, leading to nutrient maldigestion and potential deficiencies, and it is often underdiagnosed.
- The American Gastroenterological Association (AGA) created a Clinical Practice Update to improve awareness and management of EPI among healthcare professionals.
- Best Practice Advice from the review includes identifying high-risk patients (like those with chronic pancreatitis or pancreatic cancer) and considering EPI in those with moderate-risk conditions (like celiac disease or diabetes).
Typical Zollinger-Ellison syndrome-atypical location of gastrinoma and absence of hypergastrinemia: A case report and review of literature.
World J Clin Cases
September 2023
Department of Gastroenterology, The Second Affiliated Hospital of Jiaxing University, Jiaxing 314001, Zhejiang Province, China.
Article Synopsis
- Zollinger-Ellison syndrome (ZES) is caused by gastrin-secreting tumors known as gastrinomas, leading to symptoms like watery diarrhea and ulcers; however, this case presents an atypical scenario.
- A 72-year-old woman with typical ZES symptoms had normal gastrin levels and no visible gastrinoma during initial examinations, complicating her diagnosis.
- The use of a new imaging technique, 18F-OC PET/CT, ultimately identified a gastrinoma at an unusual site, highlighting the potential for ZES symptoms even in the absence of hypergastrinemia.
A Rare Case of Hepatic Gastrinoma.
Cureus
August 2023
Department of Internal Medicine, University Clinical Hospital in Bialystok, Bialystok, POL.
Article Synopsis
- * A case study highlights a 70-year-old woman with hepatic ZES who initially presented with severe sepsis due to a urinary tract infection, complicated by GI bleeding and multiple duodenal ulcers.
- * Diagnosis of gastrinoma was confirmed through tests showing high gastrin levels and a somatostatin receptor scan.