Differentiated HIV Service Delivery vs Conventional Care: Tuberculosis Preventive Therapy Outcomes for People Living with HIV in Sub-Saharan Africa.

Introduction: Differentiated service delivery (DSD) models, which are mechanisms of HIV care that reduce provider visits and offer varied ART delivery methods, are scaling up across sub- Saharan Africa. It is unknown how the movement of patients to DSD models impacts services beyond ART, including the uptake and completion of tuberculosis preventive therapy (TPT).

Methods: Using the RE-AIM framework, we analyzed data from Opt4TPT, a longitudinal cohort study examining TPT delivery in South Africa and Zimbabwe.

Revisiting water resources management in the Mandara Mountains.

This article evaluates the prospects for rainwater harvesting (RWH) as a means of optimizing water management in the Mandara Mountains. RWH is a small-scale water conservation approach for locally intercepting and storing rainfall before it enters the usual hydrologic cycle. This ancient practice has recently sustained lives in semiarid areas of the world (e.

Trabecular bone deficits predominate in the appendicular skeleton of midlife women living with HIV: findings from a cross-sectional study in Zimbabwe.

HIV-related mortality has fallen due to scale-up of antiretroviral therapy (ART), so more women living with HIV (WLH) now live to reach menopause. Menopausal estrogen loss causes bone loss, as do HIV and certain ART regimens. However, quantitative bone data from WLH are few in Africa.

Advancing Sustainable HIV Services Through Integration in Primary Healthcare in Sub-Saharan Africa: A Perspective on Practical Recommendations.

Sub-Saharan Africa continues to bear a disproportionate burden of the global HIV epidemic. Integrating HIV services into primary healthcare is a crucial strategy to accelerate progress towards ending the epidemic. However, several challenges hinder effective integration, including underfunding, human resource shortages, infrastructure limitations, weak health systems, and sociocultural factors.

Can AIDS education reduce HIV stigma? Evidence from Zimbabwe.

HIV stigma remains a barrier to HIV prevention, testing, and treatment in sub-Saharan Africa. This study uses Zimbabwe Demographic and Health Survey data to examine how education reduces HIV stigma, focusing on two key initiatives: the 1992 AIDS Action Program, which enhanced HIV awareness, and the 1980 education reform, which expanded schooling access. By addressing gaps in the literature on external HIV stigma, the study highlights education's long-term impact on attitudes toward people living with HIV.

Ethnoveterinary medicines used by smallholder farmers for treatment of goat ailments in Chikomba, Murewa, Gutu and Mwenezi districts of Zimbabwe: is there cultural consensus in use practices?

Ethnopharmacological Relevance: Zimbabwe is a key biodiversity domain in sub-Saharan Africa and ethnoveterinary medicines play an integral role in livestock health. However, knowledge on whether plants are used by only a small proportion of people or whether similar uses exist in different communities and in a more regional context is incompletely documented.

Aim Of The Study: Firstly, the study documented plant-based complementary medicines used for managing goat ailments.

Genetic diversity and population structure analyses of tropical maize inbred lines using Single Nucleotide Polymorphism markers.

Analyses of the genetic distance and composition of inbred lines are a prerequisite for parental selection and to exploit heterosis in plant breeding programs. The study aimed to assess genetic diversity and population structure of a maize germplasm panel comprising 182 founder lines and 866 derived inbred lines using Single Nucleotide Polymorphism (SNP) markers to identify genetically unique lines for hybrid breeding. The founder lines were genotyped with 1201 SNPs, and the derived lines with 1484 SNPs.

Availability of assistive technologies (ATs) to children with disabilities in Bulawayo central district (BCD) in Zimbabwe.

Availability of assistive technologies (ATs) to children with disabilities is a critical human right enshrined in United Nations (UN) treaties and frameworks such as the United Nations Conventions on the Rights of Persons with Disabilities (UNCRPD), the United Nations Conventions on Rights of the Child (UNCRC), and United Nations 2030 Agenda for Sustainable Development. ATs optimize functionality, independence, and enhance educational experiences of children with disabilities. The study explored availability of ATs to children with disabilities in Bulawayo Central District (BCD) in Zimbabwe.

Fungal Biocontrol Agents in the Management of Postharvest Losses of Fresh Produce-A Comprehensive Review.

Postharvest decay of vegetables and fruits presents a significant threat confronting sustainable food production worldwide, and in the recent times, applying synthetic fungicides has become the most popular technique of managing postharvest losses. However, there are concerns and reported proofs of hazardous impacts on consumers' health and the environment, traceable to the application of chemical treatments as preservatives on fresh produce. Physical methods, on the other hand, cause damage to fresh produce, exposing it to even more infections.

Assessment of the impact of HIV infection on the hypothalamic-pituitary-ovarian axis and pubertal development among adolescent girls at a tertiary centre in Zimbabwe: a cross-sectional study.

Background: Proper planning of reproductive health needs for HIV-infected adolescents requires a clear understanding of the effects of HIV infection on adolescents' pubertal development.

Objective: To assess the effects of HIV infection on the hypothalamic-pituitary-ovarian (HPO) axis, ovarian reserve and pubertal development in adolescent girls at a tertiary hospital in Zimbabwe.

Methods: This was a cross-sectional survey of HIV-infected adolescent girls aged 10-19 years, with available CD4 + count results at a tertiary hospital in Zimbabwe.

Strategies for effective and efficient delivery of primary health care by village health workers: A scoping review using the Rodgers' Evolutionary Concept Analysis Framework.

Background:  Village health workers (VHWs), popularly known as community health workers (CHWs) in some contexts and settings, should effectively complement health care providers in primary health care (PHC) delivery in Zimbabwe. However, they continue to offer services that do not address current and emerging health issues.

Aim:  This study aims to review the literature and develop a conceptual framework to improve the effectiveness and efficiency of VHWs in service delivery.

SARS-CoV-2 transmission dynamics in Mozambique and Zimbabwe during the first 3 years of the pandemic.

The 2019 emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its rapid spread created a public health emergency of international concern. However, the impact of the pandemic in Sub-Saharan Africa, as documented in cases, hospitalizations and deaths, appears far lower than in the Americas, Europe and Asia. Characterization of the transmission dynamics is critical for understanding how SARS-CoV-2 spreads and the true scale of the pandemic.

Perceptions of cultural and provisioning ecosystem services and human wellbeing indicators amongst indigenous communities neighbouring the greater limpopo transfrontier conservation area.

Nature plays a crucial role in providing ecosystem services (ESs) essential for human wellbeing and biodiversity conservation in rural areas. However, existing paradigms often lack an integrative approach towards rural livelihoods and wellbeing, highlighting the need for a comprehensive understanding of the relationship between human wellbeing (HWB) and ESs. The area around the Greater Limpopo Transfrontier Conservation Area (GLTFCA) offers such ESs to indigenous people who rely heavily on these natural resources.

Is Drosophila Larval Competition Involved in Incipient Speciation?

Geographical, ethological, temporal and ecological barriers can affect interbreeding between populations deriving from an ancestral population, this progressively leading to speciation. A rare case of incipient speciation currently occurs between Drosophila melanogaster populations sampled in Zimbabwe (Z) and all other populations (M). This phenomenon was initially characterized by Z females refusing to mate with M males.

High unmet needs for cervical cancer screening among women living with HIV in six African countries: A population-based study.

Background: Cisgender women living with HIV (WLWH) are disproportionately impacted by cervical cancer. Nevertheless, disparities in uptake and implementation of cervical cancer services persist in sub-Saharan Africa, where population-level estimates of screening coverage remain scarce.

Methods: We pooled data from nationally representative Population-based HIV Impact Assessment (PHIA) surveys conducted in Ethiopia, Malawi, Rwanda, Tanzania, Zambia, and Zimbabwe (2015-2019).

Strategies for strengthening cervical cancer screening programmes in Gwanda district, Zimbabwe: a qualitative study.

Background: Numerous studies have been conducted on barriers to cervical cancer screening in low resourced settings. Few have however explored the factors that motivate women to make the decision for screening. This study therefore aimed at identifying strategies that could strengthen the utilisation of screening services, with the goal of informing the development of context for enhancing cervical cancer programmes in Gwanda district, Zimbabwe.

Measurement and interpretation of the Harare HIV combination prevention cascade in priority populations: A population survey of adolescent girls and young women and young men in Zimbabwe.

Introduction: HIV-negative adolescent girls and young women (AGYW), and male partners, have disproportionately high HIV incidence in many African countries. We used a new HIV Prevention Cascade (HPC) approach to quantify levels of, and barriers to, prevention method use to guide interventions to increase effective uptake of primary HIV prevention.

Methods: Data from the Manicaland HPC pilot study (2018-19; N=9803) in Zimbabwe were used to measure levels of sexual risk behaviour and construct HPCs for male condom, PrEP (females), VMMC (males) and combination prevention use by HIV-negative sexually-active AGYW (15-24-years) and male partners (15-29-years).

Disclosure, outing and family reactions: experiences of gender and sexuality diverse individuals in Harare, Zimbabwe.

Extensive research on the process of 'coming out' underscores the significance of disclosing one's sexual orientation and gender identity for personal development and self-expression. However, sharing this information with family members can be difficult, particularly in Zimbabwe where broader social and cultural forces pose significant challenges to 'coming out', and gender and/or sexuality diversity is strongly reacted against. This paper explores the experiences of gender and sexuality diverse persons in Harare as they came out to their families, or were 'outed' by others.

Acceptability and effectiveness of a study information video in improving the research consent process for youth: a non-inferiority trial.

Introduction: Obtaining informed consent for research includes the use of information sheets, which are often long and may be difficult for participants to understand. We conducted a trial to investigate whether consent procedures using a study information video coupled with electronic consent were non-inferior to standard consent procedures using participant information sheets (PIS) among youth aged 18-24 years in Zimbabwe.

Methods: The trial was nested within an endline population-based survey for a cluster-randomised trial from October 2021 to June 2022.

Healthcare provider perspectives on integrating HIV care into cancer centers in Malawi, South Africa, Uganda, and Zimbabwe.

Background: In East and Southern Africa, treatment of people with concomitant cancer and HIV is complicated by siloed service delivery pathways, which exacerbate barriers to care and impact clinical decision-making. Integrating HIV care into cancer treatment centers may improve service delivery and overall patient outcomes.

Methods: We administered a questionnaire to clinicians and support staff at tertiary cancer referral centers in Malawi, Zimbabwe, Uganda, and South Africa to assess level of concern about clinical management of people with HIV (PWH) and cancer, barriers to integrating HIV service delivery into cancer treatment delivery, and beliefs related to HIV, antiretroviral therapy (ART), and integrated care.

Leveraging digital health systems maturity assessments to guide strategic priorities.

Background: Many low- and middle-income countries (LMICs) face the daunting task of digitising, maturing and deciding where to invest in digital health systems.

Aim: Describing the facilitators and barriers to conducting digital health maturity assessments and how health leaders can prioritise the assessments.

Setting: eHealth leaders from 10 African countries, working or supporting Ministries of Health's digital health and participating in the eHealth Leaders' Forum from July 2023 to September 2023.

Safety, Tolerability, and Pharmacokinetics of Long-Acting Broadly Neutralizing HIV-1 Monoclonal Antibody VRC07523LS in Newborn Infants Exposed to HIV-1.

Background: Vertical HIV-1 transmission despite antiretroviral therapy may be mitigated by use of long-acting, broadly neutralizing, monoclonal antibodies (bNAb) such as VRC07523LS. The present study was designed to determine the safety and pharmacokinetics of VRC07523LS.

Methods: VRC07523LS, 80 mg/dose, was administered subcutaneously after birth to non-breastfed (Cohort 1; N=11, enrolled in USA) and breastfed (Cohort 2; N=11, enrolled in South Africa and Zimbabwe) infants exposed to HIV-1.

Effectiveness of monovalent rotavirus vaccine against hospital-attended rotavirus gastroenteritis among children in Uganda.

Background: The underlying causes for lower rotavirus vaccine effectiveness (VE) in high-child-mortality settings are not well understood. Uganda introduced the human monovalent G1P[8] rotavirus vaccine (Rotarix) in June 2018. We determined the effectiveness of Rotarix against rotavirus diarrhea requiring hospital care among Ugandan children.

Living with psychosis in West and Southeast Africa: SUCCEED Africa's four-country situation analysis.

As part of the formative work of the SUCCEED Africa consortium, we followed a participatory process to identify existing gaps and resources needed for the development and implementation of a rights-based intervention for people with lived experience of psychosis in Malawi, Nigeria, Sierra Leone and Zimbabwe. In 2021, we conducted a desk review of published and grey literature on psychosis in the four SUCCEED countries. Using an adapted version of the PRIME situation analysis template, data were extracted across the five domains of the WHO Community-Based Rehabilitation (CBR) Matrix: health, education, livelihoods, social and empowerment.