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373 results match your criteria: "Zhuji People's Hospital[Affiliation]"
Bone
December 2024
Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin 300052, China. Electronic address:
Background: Differences in bone metabolism between patients with adrenal Cushing's syndrome (ACS) and Cushing's disease (CD) have been noted, but the impact of steroid hormones on bone metabolism remains underexplored. The purpose of this study is to explore the differences in bone metabolism between the two subtypes of Cushing's syndrome and the correlation between hormones synthesized by the adrenal reticulum and bone metabolism.
Method: This retrospective study included 75 premenopausal women, consisting of 33 patients with CD and 42 patients with ACS.
Transl Cancer Res
November 2024
Laboratory Medicine Center, Department of Laboratory Medicine, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, China.
Background: Gastric cancer (GC) is a malignancy with a grim prognosis, ranking as the second most common cause of cancer-related deaths globally. Various investigations have demonstrated the substantial involvement of ferroptosis and pyroptosis in the advancement of tumors. Nevertheless, the precise molecular mechanisms by which distinct genes associated with ferroptosis and pyroptosis influence the tumor microenvironment (TME) in GC remain elusive.
View Article and Find Full Text PDFFront Med (Lausanne)
November 2024
Liver Diseases Center, Ningbo No. 2 Hospital, Ningbo, China.
Background: Over the past decade, the proportion of hepatitis C virus (HCV) genotypes (GT) 1 and 2 has decreased in almost all regions of China, while GT 3 and 6 have emerged as new challenges. GT 6 is unique in many respects, like high genetic variability and emerging resistant variants. This study aims to assess the efficacy of sofosbuvir (SOF)-based treatments in patients with GT 6 chronic hepatitis C (CHC).
View Article and Find Full Text PDFOpen Med (Wars)
December 2024
Department of Orthopedics, Shaoxing People's Hospital, Shaoxing, 312000, Zhejiang, China.
Background: Osteosarcoma, a highly malignant skeletal tumor, primarily affects children and adolescents. Autophagy plays a crucial role in osteosarcoma pathophysiology. This study utilizes bibliometric analysis to evaluate current research on autophagy in osteosarcoma and forecast future directions.
View Article and Find Full Text PDFDiscov Oncol
November 2024
General Surgery Ward 4, Qinghai Provincial People's Hospital, Xining, Qinghai, China.
Background: Ferroptosis and inflammation are involved in cancer progression. The aim of this study was to identify inflammation-associated ferroptosis regulators in hepatocellular carcinoma (HCC).
Methods: FerrDb database was searched for ferroptosis-related genes.
Nat Aging
December 2024
Key Laboratory of Aging and Cancer Biology of Zhejiang Province, Zhejiang Key Laboratory of Medical Epigenetics, Hangzhou Normal University School of Basic Medical Sciences, Hangzhou, China.
Reactivation of endogenous retroviruses (ERVs) has been proposed to be involved in aging. However, the mechanism of reactivation and contribution to aging and age-associated diseases is largely unexplored. In this study, we identified a subclass of ERVs reactivated in senescent cells (termed senescence-associated ERVs (SA-ERVs)).
View Article and Find Full Text PDFAsian J Surg
November 2024
Department of Neurosurgery, People's Hospital of Longhua, Shenzhen, 518109, Guangdong, China. Electronic address:
Acad Radiol
November 2024
Department of Radiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China (X.C., J.Z., Y.P., Y.S., G.C., M.W.); Key Laboratory of Intelligent Medical Imaging of Wenzhou, Key Laboratory of Alzheimer's Disease of Zhejiang Province, Institute of Aging, Wenzhou Medical University, Wenzhou, China (M.W.).
Rationale And Objectives: Detection and diagnosis of architectural distortion (AD) on digital breast tomosynthesis (DBT) is challenging. This study applied artificial intelligence (AI) using deep learning (DL) algorithms to detect AD, followed by radiomics for classification.
Materials And Methods: 500 cases with AD on DBT reports were identified; the earlier 292 cases for training, and the later 208 cases for testing.
Oncol Lett
January 2025
Department of Radiology, Zhuji People's Hospital, Zhuji, Zhejiang 311800, P.R. China.
Eur J Nucl Med Mol Imaging
October 2024
Department of Neurology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Introduction: Progressive supranuclear palsy (PSP) is a neurodegenerative disorder with diverse clinical presentations that are linked to tau pathology. Recently, Subtype and Stage Inference (SuStaIn) algorithm, an innovative data-driven method, has been developed to model both the spatial-temporal progression and subtypes of disease. This study explores PSP progression using F-fluorodeoxyglucose (FDG) positron emission tomography (PET) imaging and the SuStaIn algorithm to identify PSP metabolic progression subtypes and understand disease mechanisms.
View Article and Find Full Text PDFAm J Mens Health
October 2024
Department of Urology, Zhuji People's Hospital, Zhuji, China.
While cisplatin remains a frontline treatment for bladder cancer (BCa), the onset of resistance greatly hampers its effectiveness. RAC3 is closely linked to chemoresistance in cancer cells, but its specific role in cisplatin resistance within BCa is still elusive. RAC3 expression in BCa was analyzed using bioinformatics and quantitative polymerase chain reaction (qPCR).
View Article and Find Full Text PDFCancer Immunol Immunother
October 2024
Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Zhonghua Xue Ye Xue Za Zhi
August 2024
Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Emerg Microbes Infect
December 2024
School of Laboratory Medicine, Hangzhou Medical College, Zhejiang, People's Republic of China.
sequence type (ST) 35 has been found in humans and animals worldwide. However, its genomic epidemiology and clonal transmission have not been explored in detail. In this study, 176 ST35 isolates from six countries were sequenced.
View Article and Find Full Text PDFSci Rep
September 2024
Emergency and Critical Care Center, ICU, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Shangtang Road 158, Hangzhou, 310014, Zhejiang, China.
Acute gastrointestinal injury (AGI) is common in mechanically ventilated (MV) patients, but the potential association between ventilatory pressure parameters and AGI grade and their impact on mortality remains unclear. This study aimed to explore the association between ventilatory pressure parameters and AGI grade, and their interaction on all-cause mortality in MV patients. This study was a secondary analysis of a multicenter, prospective, observational study that enrolled adult patients with an expected duration of mechanical ventilation ≥ 48 h from 14 general intensive care units in Zhejiang Province between March and August 2014.
View Article and Find Full Text PDFMov Disord
December 2024
Department of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Background: Primary familial brain calcification (PFBC) is a monogenic disorder characterized by bilateral calcifications in the brain. The genetic basis remains unknown in over half of the PFBC patients, indicating the existence of additional novel causative genes. NAA60 was a recently reported novel causative gene for PFBC.
View Article and Find Full Text PDFBiochem Biophys Res Commun
December 2024
Department of Cardiology, Zhuji People's Hospital, Zhejiang, China. Electronic address:
Doxorubicin (DOX), as a first-line anticancer drug, is widely used in the treatment of various cancers. However, its clinical application is restricted due to its severe cardiac toxicity. Previous studies have indicated exercise training can alleviate the DOX-induced cardiotoxicity (DIC), but the underlying mechanism remains unclear.
View Article and Find Full Text PDFBiomed Pharmacother
October 2024
Cancer Institute of Integrative Chinese and Western Medicine, Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang 310012, China; Hangzhou Medical College, Hangzhou, Zhejiang 310059, China. Electronic address:
Nat Sci Sleep
August 2024
Department of Neurology and Center for Sleep Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China.
Narcolepsy type 1 (NT1) is a unique central sleepiness disorder that affects individuals with excessive daytime sleepiness (EDS), cataplexy, sleep paralysis, and hypnagogic hallucinations. The etiology and pathogenesis of NT1 remains unclear, although some viral infections are thought to be related to NT1. This paper reports an unusual case of late-onset NT1 with human immunodeficiency virus (HIV) infection and antiretroviral therapy for five years.
View Article and Find Full Text PDFFront Nutr
July 2024
Department of Anesthesiology, Zhuji People's Hospital, Shaoxing University, Zhuji, China.
Oncol Lett
October 2024
Department of Radiology, Zhuji People's Hospital, Zhuji, Zhejiang 311800, P.R. China.
Oncol Res
July 2024
Department of Hematology, Zhuji People's Hospital, Shaoxing, 311800, China.
Multiple myeloma (MM) is a plasma cell malignancy and remains incurable as it lacks effective curative approaches; thus, novel therapeutic strategies are desperately needed. The study aimed to explore the therapeutic role of dihydromyricetin (DHM) in MM and explore its mechanisms. Human MM and normal plasma samples, human MM cell lines, and normal plasma cells were used for experiments.
View Article and Find Full Text PDFInt J Low Extrem Wounds
July 2024
Department of Endocrinology, Tongde Hospital of Zhejiang Province, Hangzhou, China.
Purpose: We aim to evaluate the efficacy of local antibiotic delivery systems in patients with diabetic foot osteomyelitis (DFO).
Methods: The Web of Science, PubMed, and Embase databases were searched for relevant publications until March 2024. All studies evaluating the efficacy of local antibiotic delivery systems in patients with DFO were included.
Biomed Pharmacother
August 2024
Cancer Institute of Integrative Chinese and Western Medicine, Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang 310012, China; Hangzhou Medical College, Hangzhou, Zhejiang 310059, China. Electronic address:
Lung adenocarcinoma (LUAD) is the leading cause of cancer death worldwide, with high incidence and low survival rates. Nicotinic acetylcholine receptors play an important role in the progression of LUAD. In this study, a screening of 17 nicotinic acetylcholine receptor allosteric agents revealed that spinosad effectively suppressed the proliferation of LUAD cells.
View Article and Find Full Text PDFJ Infect Dev Ctries
June 2024
Department of Respiratory Medicine, Changxing Hospital of Zhejiang Medical Health Group, Changxing 313117, Zhejiang Province, China.
Introduction: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death in the world. We aimed to investigate the associations between toll-like receptors 2 and 4 (TLR-2 and TLR-4) and β-lactam antibiotics in COPD patients complicated with pulmonary infections.
Methodology: A total of 156 COPD patients complicated with pulmonary infections were included.