Association between weight-adjusted-waist index and the prevalence of gallstone disease in Minhang District, Shanghai: a cross-sectional study.

Background: Gallstone disease (GSD) is a common and costly health issue with a multifactorial etiology linked to obesity. The Weight-Adjusted-Waist Index (WWI) is a novel anthropometric measure that incorporates both weight and waist circumference, potentially offering a better assessment of GSD risk associated with adiposity. This study aims to evaluate the association between WWI and the prevalence of GSD.

Targeting CCL2-CCR2 signaling pathway alleviates macrophage dysfunction in COPD via PI3K-AKT axis.

Background: Chronic obstructive pulmonary disease (COPD) remains a leading cause of morbidity and mortality worldwide, characterized by persistent respiratory symptoms and airflow limitation. The involvement of C-C motif chemokine ligand 2 (CCL2) in COPD pathogenesis, particularly in macrophage regulation and activation, is poorly understood despite its recognized role in chronic inflammation. Our study aims to elucidate the regulatory role and molecular mechanisms of CCL2 in the pathogenesis of COPD, providing new insights for therapeutic strategies.

Efficacy of a Self-Designed Questionnaire for Community Screening of COPD.

Purpose: To evaluate the screening efficacy of a self-designed questionnaire for chronic obstructive pulmonary disease (COPD) and the potential gender disparity in its efficacy.

Patients And Methods: A screening questionnaire, the COPD Screening Questionnaire-Minhang (COPD-MH), was designed with reference to the self-scored COPD population screener (COPD-PS) and the COPD screening questionnaire (COPD-SQ), incorporating characteristics of the local population in Shanghai, China. The revised questionnaire included only five questions.