Cell adhesion and apoptosis in ovarian stromal hyperplasia and hyperthecosis.

The aim of our study was to investigate cell adhesion and apoptosis in ovarian stromal hyperplasia and hyperthecosis in reproductive women with and without polycystic ovarian disease. We have studied 104 patients with a histological diagnosis of ovarian stromal hyperthecosis and stromal hyperplasia. Paraffin sections were stained by hematoxylin-eosin, von Gieson and immunohistochemistry for Bcl-2 (anti-apoptotic protein) and E-cadherin (cell adhesion marker).

Proliferation and apoptosis in ovarian stromal hyperplasia and hyperthecosis.

The aim of our study was to investigate proliferation and apoptosis in ovarian stromal hyperplasia and hyperthecosis in reproductive women with and without polycystic ovarian disease. We have studied 104 patients with a histological diagnosis of ovarian stromal hyperthecosis and stromal hyperplasia. Paraffin sections were stained by hematoxylin-eosin, von Gieson and immunohistochemistry for Bcl-2 (anti-apoptotic protein) and Ki-67 antigen (proliferation marker).

[Results of application of high daily doses of recombinant follicle stimulating hormone in different age groups of women in IVF program].

A prospective, randomized, comparative study has been carried out to investigate the effectiveness of administration of recombinant FSH (rFSH, Gonal-F) in doses 150 and 225 IU in different age groups of women. 63 patients started a long gonadotrophin-releasing hormone agonist protocol (GnRHa, Diphereline, 0,1 mg): 31 received rFSH 150 IU/day and 32 - 225 IU/day. The objective was to assess the impact of these dosing regimens in down-regulated women.

[Histological and morphological characteristics of the different stages of cervical glandular intraepithelial neoplasia].

Currently there is no world system classification of glandular hyperplasia of uterine cervix (endocervix). Different authors give nonmonosemantic estimations to each type of cervical hyperplasia. Cervical Glandular Intraepithelial Neoplasia (CGIN) or Glandular Dysplasia is considered as a precancerous lesion of endocervix.

[The use of gonadotropin-releasing hormone agonist (GnRH-a) dipherelin 3,75 mg for in vitro fertilization program].

For the purpose of optimizing the superovulation stimulation and improving clinical outcome, the gonadotropin-releasing hormone (GnRH-a) agonist were successfully used in the in vitro fertilization program. Under observation were 200 women of the reproductive age with the average length of sterility 7,6+/-4,1 years. The causes of sterility were as follows: tubo-peritoneal factor 84 (42%), endometriosis 54 (27%), PCOS 24 (19%), unknown infertility 38 (19%).

[Oxidative processes in the cervical and vaginal epithelial tissue in patients with HPV infection].

Genital human papilloma virus (HPV) infection is the sexually transmitted disease. HPV induces the proliferation of epithelial cells. In the areas of viral inclusions vulvovaginal warts, papillomas and condylomas are developing.