11 results match your criteria: "Zhongshan Ophthalmic Center at Sun Yat-sen University[Affiliation]"
Comparison of photodynamic therapy with two different parameters combined with subconjunctival injection of bevacizumab for corneal neovascularization.
Photodiagnosis Photodyn Ther
April 2024
The State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center at Sun Yat-sen University, Guangzhou 510060, China. Electronic address:
Article Synopsis
- - This study aimed to assess the effectiveness of two different photodynamic therapy (PDT) protocols combined with the drug bevacizumab for treating corneal neovascularization (CNV) in patients unresponsive to conventional treatments.
- - Patients were divided into two groups: one received lower energy PDT parameters, while the other received higher energy parameters, with the bevacizumab injection given immediately after PDT.
- - Results showed that overall, 60% of patients experienced improved vision and there was a significant reduction in neovascularization, particularly in the group that received the higher energy treatment, demonstrating the potential of optimized combined therapy for CNV.
Effects of PPAR-γ and RXR-α on mouse meibomian gland epithelial cells during inflammation induced by latanoprost.
Exp Eye Res
November 2022
Zhongshan Ophthalmic Center at Sun Yat-sen University, The State Key Laboratory of Ophthalmology, Guangdong Provincial Institute for Vision and Eye Research, #54 Xianlie South Road, Guangzhou, 510060, China. Electronic address:
The purpose of this study is to investigate the effects of latanoprost on the secretion of cytokines and chemokines from meibomian gland epithelial cells, and to evaluate the modulation of peroxisome proliferator-activated receptor γ (PPAR-γ) and retinoid X receptor α (RXR-α) during latanoprost-induced inflammation. Mouse meibomian gland epithelial cells were cultured in proliferation and differentiation medium, respectively. Cells were exposed to latanoprost, rosiglitazone (PPAR-γ agonist), or LG100268 (RXR-α agonist), respectively.
View Article and Find Full Text PDFMYRF: A Mysterious Membrane-Bound Transcription Factor Involved in Myelin Development and Human Diseases.
Neurosci Bull
June 2021
Institute of Life Sciences, Zhejiang Key Laboratory of Organ Development and Regeneration, College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, 311121, China.
DNA variants represent an important source of genetic variations among individuals. Next- generation sequencing (NGS) is the most popular technology for genome-wide variant calling. Third-generation sequencing (TGS) has also recently been used in genetic studies.
View Article and Find Full Text PDFSafety of antivascular endothelial growth factor administration in the ocular anterior segment in pterygium and neovascular glaucoma treatment: Systematic review and meta-analysis.
Medicine (Baltimore)
August 2018
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center at Sun Yat-sen University, Guangzhou, China.
Background: Anti-VEGF agents has been widely used in ocular diseases, but its safety for treating anterior segment disorders, the conclusions are controversial.
Methods: Several major databases, including CENTRAL, MEDLINE, and EMBASE, were searched. Safety data from 18 randomized controlled trials (RCTs) were used to compare anti-VEGF treatment in the ocular anterior segment in pterygium and neovascular glaucoma treatment with placebo/sham treatment for eye diseases.
Case report of ocular Kaposi's sarcoma.
BMC Ophthalmol
August 2017
The State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center at Sun Yat-sen University, #54 Xian lie South Road, Guangzhou, 510060, China.
Article Synopsis
- Kaposi's sarcoma (KS) is a type of cancer originating from blood vessels, often seen in patients with HIV/AIDS or those who have undergone immunosuppressive treatments.
- A rare case of ocular KS was reported in a 13-year-old male who developed the condition post-stem cell transplant, despite not having HIV or HHV-8 infection.
- Treatment involved a combination of surgical excision and grafts, including mitomycin C, which successfully cured the KS and helped prevent recurrence.
Collagen crosslinking of porcine sclera using genipin.
Acta Ophthalmol
June 2013
Zhongshan Ophthalmic Center at Sun Yat-sen University, The State Key Laboratory of Ophthalmology, Guangzhou, China.
Purpose: To evaluate the effect of collagen cross-linking induced by genipin in porcine sclera.
Methods: Porcine cadaver eyes were treated with genipin at concentrations (by w/v) of 0.01%, 0.
Optical coherence tomography and ultrasound biomicroscopy imaging of opaque corneas.
Cornea
April 2013
Corneal Division, Zhongshan Ophthalmic Center at Sun Yat-sen University, The State Key Laboratory of Ophthalmology, Guangzhou, China.
Purpose: The purpose was to determine the interchangeability of ultrasound biomicroscopy (UBM) and anterior segment optical coherence tomography (AS-OCT) for corneal opacity depth measurement.
Methods: Twenty-six eyes of 26 consecutive patients with corneal opacities were examined by both AS-OCT and UBM. The corneal thickness and the corneal opacity depth were measured and compared.
Anterior segment OCT-based diagnosis and management of Descemet's membrane detachment.
Ophthalmologica
September 2012
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center at Sun Yat-sen University, Guangzhou, China.
Aims: To evaluate anterior segment optical coherence tomography (AS-OCT) in the diagnosis and treatment of Descemet's membrane detachment (DMD) with severe corneal edema.
Methods: Nine eyes of 7 consecutive patients with suspected DMD with severe corneal edema due to different causes were imaged with the AS-OCT system. Configuration of Descemet's membrane (DM) was delineated before and after treatment, and quantitative analysis was performed.
Ocular safety and pharmacokinetics study of FK506 suspension eye drops after corneal transplantation.
J Ocul Pharmacol Ther
April 2012
Zhongshan Ophthalmic Center at Sun Yat-sen University, The State Key Laboratory of Ophthalmology, Guangzhou, China.
Purpose: The aim of this study was to investigate the sensitization, pharmacokinetics, and absorption of FK506 after corneal transplantation.
Methods: New Zealand albino rabbits were divided into normal and corneal transplantation groups. Each group was divided into 5 subgroups--saline, blank matrix, high-dose, medium-dose, and low-dose, respectively.
Preparation of 0.05% FK506 suspension eyedrops and its pharmacokinetics after topical ocular administration.
J Ocul Pharmacol Ther
August 2009
Zhongshan Ophthalmic Center at Sun Yat-sen University, The State Key Laboratory of Ophthalmology, Sun Yat-sen University, 54 south Xianlie Road, Guangzhou, People's Republic of China.
Purpose: To investigate the stability of FK506 eye suspension and its pharmacokinetics in rabbit aqueous humor, as well as its distribution in eye tissues.
Methods: Sedimentation rate, flocculation value, redispersion time, rheological study, and accelerated experiment were determined for evaluating the stability of FK506 suspension. In a single-dose pharmacokinetic study, six rabbits were instilled a 25-microL drop of 0.