Developing a new treatment for superficial fungal infection using antifungal Collagen-HSAF dressing.

Fungal pathogens are common causes of superficial clinical infection. Their increasing drug resistance gradually makes existing antifungal drugs ineffective. Heat stable antifungal factor (HSAF) is a novel antifungal natural product with a unique structure.

ddRAD-Seq reveals evolutionary insights into population differentiation and the cryptic phylogeography of in Mainland China.

Species differentiation and local adaptation in heterogeneous environments have attracted much attention, although little is known about the mechanisms involved. is an anadromous, brackish-water halfbeak that is widely distributed in coastal areas and hyperdiverse freshwater systems in China, making it an interesting model for research on phylogeography and local adaptation. Here, 156 individuals were sampled at eight sites from heterogeneous aquatic habitats to examine environmental and genetic contributions to phenotypic divergence.

MomL inhibits bacterial antibiotic resistance through the starvation stringent response pathway.

Antibiotic resistance in gram-negative pathogens has become one of the most serious global public health threats. The role of the -acyl homoserine lactone (AHL)-mediated signaling pathway, which is widespread in gram-negative bacteria, in the bacterial resistance process should be studied in depth. Here, we report a degrading enzyme of AHLs, MomL, that inhibits the antibiotic resistance of through a novel mechanism.

Use of artificial structures to enhance fish diversity in the Youjiang River, a dammed river of the Pearl River in China.

The fragmentation and homogenization of habitats have seriously affected the fishery resources of the Pearl River. To protect the fishery resources, a novel artificial habitat, constructed using bamboo and palm slices, was deployed in the Youjiang River, a tributary of the Pearl River in China. The results of field and laboratory experiments showed that fish abundance, species richness and Shannon-Wiener diversity index were higher in the artificial habitats than at the control sites.

Long-term therapeutic effect in nonhuman primate eye from a single injection of anti-VEGF controlled release hydrogel.

Wet age-related macular degeneration (wet-AMD) is a leading cause of irreversible blindness. Current treatment of AMD requires monthly intravitreal injection, which is difficult to be implemented in many parts of the world. In recent years, controlled release of anti-vascular endothelial growth factor (VEGF) therapeutics has attracted intense research interest aiming to reduce the injection frequency to one or two times per year.