6,037 results match your criteria: "Zhongshan Ophthalmic Center[Affiliation]"

Comparison of rotational stability of the implantable collamer lens after using a vertical or horizontal implanting orientation.

J Cataract Refract Surg

January 2025

From the State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China (Zhao, Wan, Chen, Ye, Yang, Zhuang, Yu); Shenzhen Eye Hospital, Jinan University, Shenzhen Eye Institute, Shenzhen, China (Zhao).

Purpose: To compare rotational stability of the implantable collamer lens (ICL) between horizontal and vertical implantation.

Setting: Zhongshan Ophthalmic Center, Guangzhou, China.

Design: Prospective 1:1 matched design.

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Objective quantification of posterior capsule opacification using swept-source AS-OCT.

J Cataract Refract Surg

January 2025

From the State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China.

Purpose: To objectively quantify posterior capsule opacification (PCO) using swept-source anterior segment optical coherence tomography (SS-AS-OCT) in pseudophakic eyes.

Setting: Zhongshan Ophthalmic Center, Guangzhou, China.

Design: Prospective cross-sectional study.

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Comparative single-cell transcriptomic analysis across tissues of aging primates reveals specific autologous activation of ZNF281 to mitigate oxidative stress in cornea.

Aging Cell

December 2024

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology Visual Science, Guangzhou, China.

Reactive oxygen species (ROS) and oxidative stress accelerate cellular aging, but their impact on different tissues varies. The cornea, known for its robust antioxidant defense systems, is relatively resistant to age-related diseases like cancer. However, the precise mechanisms by which the cornea maintains ROS homeostasis during aging remain unclear.

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Peripapillary Retinal Nerve Fiber Layer and Macular Ganglion Cell-Inner Plexiform Layer Parameters and Their Associated Factors in Cynomolgus Macaques.

Invest Ophthalmol Vis Sci

September 2024

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China.

Purpose: The purpose of this study was to define the normal range of peripapillary retinal nerve fiber layer (pRNFL), macular ganglion cell layer (mGCL), and macular inner plexiform layer (mIPL) thickness in cynomolgus macaques, and explore their inter-relationship and correlation with age, refractive errors, and axial length (AL).

Methods: In this cross-sectional study, we measured biometric and refractive parameters, and pRNFL/mGCL/mIPL thickness in 357 healthy cynomolgus macaques. Monkeys were divided into groups by age and spherical equivalent (SE).

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Association of Retinal Nerve Fiber Layer Thinning With Elevated High Density Lipoprotein Cholesterol in UK Biobank.

Invest Ophthalmol Vis Sci

September 2024

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China.

Article Synopsis
  • - The study aimed to explore the relationship between retinal nerve fiber layer (RNFL) thickness and high-density lipoprotein cholesterol (HDL-C) levels in a healthy population of 31,738 UK Biobank participants, using advanced imaging techniques.
  • - Results showed that high HDL-C levels were linked to thinner RNFL thickness in both men and women, while moderate HDL-C levels were positively associated with thicker RNFL in women, indicating a complex relationship between cholesterol and eye health.
  • - The findings suggest that elevated HDL-C could be a potential risk factor for neurodegenerative diseases, highlighting its importance for preventive healthcare strategies.
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An L-type calcium channel blocker nimodipine exerts anti-fibrotic effects by attenuating TGF-β1 induced calcium response in an in vitro model of thyroid eye disease.

Eye Vis (Lond)

September 2024

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology Visual Science, Guangzhou, 510060, China.

Article Synopsis
  • - The study investigates the role of calcium (Ca) signaling in tissue fibrosis related to thyroid eye disease (TED), a serious autoimmune disorder affecting vision, and evaluates the therapeutic potential of nimodipine, an L-type calcium channel (LTCC) inhibitor.
  • - Researchers used primary cultures of orbital fibroblasts from TED patients and healthy donors, employing various techniques like RT-qPCR and flow cytometry to measure changes in gene expression and cell behavior in response to TGF-β1, a fibrosis-inducing factor.
  • - Results showed that nimodipine effectively blocked the Ca response triggered by TGF-β1, leading to a decrease in fibrogenic markers such as α-SMA and collagen types I and
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Clinical spectrum and possible pathogenesis of progressive outer retinal necrosis.

Br J Ophthalmol

December 2024

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, Guangdong, China.

Objective: Progressive outer retinal necrosis (PORN) is an alphaherpesvirus-caused panuveitis with devastating consequences for the eye. Our study aims to describe new findings in the clinical spectrum and propose a mechanism for the pathogenesis of PORN.

Methods: Observational, consecutive case series.

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Carbon dioxide laser excision as a novel treatment for large xanthelasma palpebrarum: long-term efficacy and safety.

Br J Ophthalmol

September 2024

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China

Article Synopsis
  • - This study investigates the safety and effectiveness of CO₂ laser excision as a treatment for large xanthelasma palpebrarum in 295 patients, who were followed for one year after the procedure.
  • - Results showed over 99% clearance for most cases, with a 6.8% recurrence rate, particularly higher in lesions larger than 2 mm; reported complications included minor issues like scarring and skin discoloration.
  • - The findings suggest that CO₂ laser excision is a precise and minimally invasive option for treatment, although more research is needed to enhance treatment approaches.
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Retinal and Choroidal Phenotypes Across Novel Subtypes of Type 2 Diabetes Mellitus.

Am J Ophthalmol

January 2025

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Study Center for Ocular Diseases, Guangzhou, China; Hainan Eye Hospital and Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Haikou, China. Electronic address:

Article Synopsis
  • The study aimed to analyze changes in choroidal thickness (CT) and ganglion cell-inner plexiform layer thickness (GC-IPLT) in different types of type 2 diabetes mellitus (T2DM) patients over a 4-year period.
  • It categorized patients into five groups based on their β-cell function and insulin resistance, measuring CT and GC-IPLT at the start and after four years using advanced imaging techniques.
  • Results showed significant thinning of both CT and GC-IPLT in all groups, with SIDD patients experiencing the fastest decline in CT and SIRD showing the greatest loss in GC-IPLT, indicating microvascular damage and early retinal degeneration linked to these diabetes phenotypes.
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Lens Power and Associated Factors in Nonhuman Primate Subjects: A Cross-sectional Study.

Invest Ophthalmol Vis Sci

September 2024

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China.

Purpose: We aimed to examine the normative profile of crystalline lens power (LP) and its associations with ocular biometric parameters including age, axial length (AL), spherical equivalent refraction (SE), corneal radius (CR), lens thickness, anterior chamber depth, and AL/CR ratio among a cynomolgus monkey colony.

Methods: This population-based cross-sectional Non-human Primate Eye Study recruited middle-aged subjects in South China. All included macaques underwent a detailed ophthalmic examination.

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Quickly diagnosing Bietti crystalline dystrophy with deep learning.

iScience

September 2024

Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Article Synopsis
  • Bietti crystalline dystrophy (BCD) is a challenging inherited retinal disease that requires early diagnosis, which this study aims to improve through deep learning techniques.
  • The research involves labeling ultra-wide-field color fundus photographs to classify images as BCD, retinitis pigmentosa, or normal, and further categorizing BCD patients into three clinical stages.
  • Three deep learning models (ResNeXt, Wide ResNet, and ResNeSt) were evaluated for their diagnostic accuracy and effectiveness, resulting in the creation of a significant BCD database for the Chinese population and a promising automated diagnosis method for future clinical use.
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Vision Improvement in Keratoconus Patients Trained With Perceptual Learning: A Randomized Controlled Trial.

Am J Ophthalmol

January 2025

From the State Key Laboratory of Ophthalmology (X.-H.T., M.-Y.W., J.-Y.J., D.L., S.-S.C., C.-Q.X., X.-Y.L., Y.H., X.Y.), Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, Guangdong Province, China. Electronic address:

Purpose: To investigate the effectiveness and maintenance of perceptional learning (PL) on vision improvement in keratoconus (KC) patients corrected with spectacles.

Design: Randomized, double-blind clinical trial.

Methods: Non-progressive KC patients 9 years of age or older who had best spectacle-corrected distance visual acuity (CDVA) of 0 to 1.

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The Impact of Intraocular Pressure Changes on Corneal Biomechanics in Primary Open-angle Glaucoma.

Am J Ophthalmol

January 2025

From the State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases (Y.X., Y.Y., Z.C., J.X., Y.Y., Y.Z., P.L., Y.F., K.Y., M.Y.), Guangzhou, China. Electronic address:

Purpose: To investigate the relationship between intraocular pressure (IOP) changes and corneal biomechanical properties, determine the quantitative relationship between IOP changes and corneal biomechanical properties in patients with glaucoma and observe the differences among different types of glaucoma when the effects of high-level IOP were excluded.

Design: Prospective clinical cohort study.

Methods: Setting: Institutional.

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Quantitative analysis of peripapillary capillary volume using dense B-scan OCT angiography in normal and diabetic retina.

Eye Vis (Lond)

September 2024

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, 7# Jinsui Road, Guangzhou, 510000, China.

Background: The value of quantitatively analyzing peripapillary capillary volume (PPCV) distribution was explored in normal and diabetic retinopathy (DR) eyes using dense B-scan optical coherence tomography angiography (DB OCTA).

Methods: This was a cross-sectional observational study followed by prospective follow-up for those with DR, which enrolled 101 healthy subjects and 140 DR patients. Dense, automatic, real-time (DART) volume scans of DB OCTA were performed using a Spectralis HRA + OCT2.

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The Systemic Genotype-Phenotype Characterization of PAX6-Related Eye Disease in 164 Chinese Families.

Invest Ophthalmol Vis Sci

August 2024

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China.

Purpose: This study aims to evaluate the genetic and phenotypic characteristics and elucidate the genotype-phenotype correlations of a large Chinese cohort with PAX6-related disorders.

Methods: Variants detected with exome sequencing were filtered through multistep bioinformatic and co-segregation analyses, and validated by Sanger sequencing. The related clinical data were collected, and cluster analysis and statistical analysis of the PAX6-related phenotypes across different variant groups were carried out.

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Clinical Outcomes of Descemet Membrane Endothelial Keratoplasty for Iridocorneal Endothelial Syndrome With a Glaucoma Drainage Device.

Cornea

August 2024

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China; and.

Purpose: The purpose of this study was to evaluate the feasibility and clinical outcomes of Descemet membrane endothelial keratoplasty (DMEK) for treating iridocorneal endothelial (ICE) syndrome with a glaucoma drainage device (GDD).

Methods: In this retrospective, interventional case series, data of ICE eyes with a GDD treated with DMEK were collected at the Zhongshan Ophthalmic Center. A total of 24 patients (24 eyes) with mild-to-moderate ocular anterior segment anomalies together with good intraocular pressure (IOP) control preoperatively were included between March 10, 2014, and November 11, 2021.

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Light-Activated Anti-Vascular Combination Therapy against Choroidal Neovascularization.

Adv Sci (Weinh)

October 2024

State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, 999077, China.

Choroidal neovascularization (CNV) underlies the crux of many angiogenic eye disorders. Although medications that target vascular endothelial growth factor (VEGF) are approved for treating CNV, their effectiveness in destroying new blood vessels is limited, and invasive intravitreal administration is required. Additionally, other drugs that destroy established neovessels, such as combretastatin A-4, may have systemic side effects that limit their therapeutic benefits.

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An Interpretable System for Screening the Severity Level of Retinopathy in Premature Infants Using Deep Learning.

Bioengineering (Basel)

August 2024

State Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.

Accurate evaluation of retinopathy of prematurity (ROP) severity is vital for screening and proper treatment. Current deep-learning-based automated AI systems for assessing ROP severity do not follow clinical guidelines and are opaque. The aim of this study is to develop an interpretable AI system by mimicking the clinical screening process to determine ROP severity level.

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Combining functional and morphological retinal vascular characteristics achieves high-precision diagnosis of mild non-proliferative diabetic retinopathy.

J Transl Med

August 2024

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Sun Yat-sen University, Guangzhou, China.

Background: To explore the functional and morphological variations of retinal vessels in diabetes with no clinically detectable retinopathy (NDR) and mild non-proliferative diabetic retinopathy (NPDR) and to establish a high-performance mild NPDR diagnostic model.

Methods: Normal subjects and type 2 diabetes patients with NDR and mild NPDR were recruited. Oxygen-saturation-related functional parameter (optical density ratio ODR) and morphological characteristics (fractal dimension D, vessel area rate VAR, mean vascular diameter D, vessel tortuosity τ) of different vascular areas were extracted with single fundus photography and comprehensively analyzed among groups.

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Purpose: To investigate the correlation between whole eye movement (WEM) parameters measured using Corvis ST and axial length (AL) to explore whether AL affects WEMs.

Methods: This single-center, cross-sectional study included data from healthy subjects and patients preparing for refractive surgery at the Qingdao Eye Hospital of Shandong First Medical University. Data were collected from July 2021 to April 2022.

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Artificial intelligence in corneal diseases: A narrative review.

Cont Lens Anterior Eye

December 2024

The Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, United States; Departments of Ophthalmology, Neurology, and Neurosurgery, Weill Cornell Medicine, New York, NY, United States; Department of Ophthalmology, University of Texas Medical Branch, Galveston, TX, United States; University of Texas MD Anderson Cancer Center, Houston, TX, United States; Texas A&M College of Medicine, TX, United States; Department of Ophthalmology, The University of Iowa Hospitals and Clinics, Iowa City, IA, United States.

Article Synopsis
  • Corneal diseases are increasingly problematic, especially in areas with limited eye care resources, but AI can help automate their diagnosis and management.
  • This review highlights AI’s effectiveness in diagnosing various corneal conditions, showing it often surpasses human accuracy by using combined imaging and clinical data.
  • Although there are challenges like diverse patient populations and the complexity of AI models, advancements in explainable AI and better data handling can improve the situation.
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Trajectories of choriocapillaris perfusion in healthy individuals and patients with diabetes mellitus: a prospective cohort study.

Br J Ophthalmol

August 2024

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, Guangdong, China

Purpose: To evaluate the longitudinal rate of choriocapillaris flow deficits (CFD) in healthy participants and patients with diabetes mellitus.

Methods: This prospective cohort study included healthy individuals and diabetic patients without diabetic retinopathy (non-DR) or with mild-to-moderate non-proliferative DR (NPDR). The swept-source optical coherence tomography angiography (OCTA) was adopted for quantifying CFD annually, and linear mixed models were used to analyse the CFD change and its 95% CI overtime.

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Article Synopsis
  • The review investigates the effectiveness of using ultra-pulsed CO2 fractional laser therapy combined with recombinant human epidermal growth factor (rHEGF) gel in treating keloids on the eyelids.
  • A total of 98 patients who underwent surgery were divided into two groups, one receiving the combination treatment and the other only laser therapy; after dropouts, 47 and 46 cases were analyzed.
  • Results showed that while no significant differences were detected in baseline characteristics between groups, the combination treatment significantly improved scar assessment scores compared to laser therapy alone.
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The Onset and Progression of Myopia Slows in Chinese 15-Year-Old Adolescents Following Vocational Rather Than Academic School Pathways.

Invest Ophthalmol Vis Sci

August 2024

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China.

Article Synopsis
  • - The study examined how different educational streams (academic vs. vocational) affect spherical equivalent (SE) and axial length (AL) changes, as well as the rates of myopia among Chinese adolescents aged 15.
  • - 880 first-born twins were followed from ages 7 to 18, and results showed that both educational streams experienced similar myopic development until age 15, but differed significantly in cumulative incidence rates of myopia after that age.
  • - The findings indicated that students in vocational high school (VHS) had a significantly lower incidence of myopia compared to those in academic high school (AHS), suggesting that education type may influence eye health outcomes.
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Long-Term Prediction and Risk Factors for Incident Visual Field Defect in Nonpathologic High Myopia.

Invest Ophthalmol Vis Sci

August 2024

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China.

Purpose: To investigate the long-term patterns and risk factors of visual field defect (VFD) development in nonpathologic high myopia (HM) over an 8-year follow-up.

Methods: This was an observational cohort study. The VFD classification adhered to the Glaucoma Suspects with High Myopia Study Group.

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