10,214 results match your criteria: "Zhongnan Hospital[Affiliation]"
USP7 depletion potentiates HIF2α degradation and inhibits clear cell renal cell carcinoma progression.
Cell Death Dis
October 2024
The First Affiliated Hospital of Xi'an Jiaotong University, Center for Precision Cancer Medicine, MED-X Institute, 710000, Xi'an, China.
Clear cell renal cell carcinoma (ccRCC) is characterized by Von Hippel Lindau (VHL) gene loss of function mutation, which leads to the accumulation of hypoxia-inducible factor 2α (HIF2α). HIF2α has been well-established as one of the major oncogenic drivers of ccRCC, however, its therapeutic targeting remains a challenge. Through an analysis of proteomic data from ccRCCs and adjacent non-tumor tissues, we herein revealed that Ubiquitin-Specific Peptidase 7 (USP7) was upregulated in tumor tissues, and its depletion by inhibitors or shRNAs caused significant suppression of tumor progression in vitro and in vivo.
View Article and Find Full Text PDFResponse to comments on 'Mechanisms of psycho-behavioural mindfulness intervention (MCARE) on depressive and anxiety symptoms in patients with acute coronary syndrome: A longitudinal mediation analysis'.
J Psychosom Res
December 2024
Center for Wise Information Technology of Mental Health Nursing Research, School of Nursing, Wuhan University, Wuhan, China. Electronic address:
Weight-adjusted waist index is positively and linearly associated with all-cause and cardiovascular mortality in metabolic dysfunction-associated steatotic liver disease: findings from NHANES 1999-2018.
Front Endocrinol (Lausanne)
October 2024
Department of Gastroenterology, Tongren Hospital of Wuhan University (WuHan Third Hospital), Wuhan, China.
Article Synopsis
- Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common chronic liver condition, and the study investigates how the weight-adjusted waist index (WWI) correlates with mortality rates in affected individuals, compared to the traditional BMI metric.
- The research used data from adults with MASLD between 1999-2018, analyzing their waist circumference and body weight to assess WWI and its impact on both all-cause and cardiovascular disease mortality.
- Results showed that higher WWI is linked to an increased risk of mortality even after adjusting for BMI, suggesting that WWI is a more accurate predictor of health risks in MASLD patients than BMI alone.
Advances and trends in pressure ulcer care research over the last 20 years: A bibliometric and visual analysis.
Heliyon
October 2024
Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, China.
Article Synopsis
- The study analyzes the trends in pressure ulcer care research over the last 20 years, using bibliometric and visual analysis to inform clinical practices and further research.
- A total of 5,102 publications were identified, showcasing a steady annual increase of 4.89% in research output, with key focus areas including epidemiology, risk assessment, and interventions.
- Recent research hotspots include education on pressure ulcers and care specific to COVID-19 patients, indicating a need for continued exploration, particularly concerning pressure ulcer care in the elderly population.
Targeting the LMP1-ALIX axis in EBV nasopharyngeal carcinoma inhibits immunosuppressive small extracellular vesicle secretion and boosts anti-tumor immunity.
Cancer Commun (Lond)
December 2024
Department of Radiation and Medical Oncology, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, P. R. China.
Article Synopsis
- Immunotherapy for nasopharyngeal carcinoma (NPC) is effective but has low response rates; the role of PD-L1 on small extracellular vesicles (sEVs) in tumor immunosuppression is a key focus of research.
- The study investigates how the Epstein-Barr virus protein LMP1 influences tumor immunity in NPC by analyzing T cell presence and sEV characteristics in both human tissues and mouse models.
- Results show that high LMP1 levels limit CD8 T cell infiltration and promote PD-L1 secretion through interactions with ALIX, suggesting a potential pathway for therapeutic intervention to enhance immune responses in NPC.
The detection, biological function, and liquid biopsy application of extracellular vesicle-associated DNA.
Biomark Res
October 2024
Department of Biological Repositories, Human Genetic Resources Preservation Center of Hubei Province, Zhongnan Hospital of Wuhan University, Wuhan, China.
Article Synopsis
- Cell-derived extracellular vesicles (EVs) are tiny particles released by cells, containing various biomolecules like DNA, proteins, and lipids that reflect their originating cells.
- EVs facilitate communication between cells and can act as biomarkers for diseases, with a particular focus on DNA fragments (EV-DNA) from both the genomic and mitochondrial origins.
- The review discusses advances in detecting EV-DNA, its potential to influence recipient cell functions, and its clinical applications as biomarkers in liquid biopsies, aiming to guide future research in this area.
Analysis of poor work postures during morning care operations of intensive care unit nurses: a field research.
BMC Nurs
October 2024
Teaching and Research Section of Clinical Nursing, Xiangya Hospital of Central South University, Changsha, China.
Background: Poor working postures in morning care operations contribute significantly to work-related muscle fatigue and low back pain among ICU (Intensive Care Unit, ICU) nurses. However,there are few field studies on the relationship between Poor working postures and work-related muscle fatigue, low back pain among ICU nurses.
Objective: This study aims to assess the frequency and degree of posture hazards associated with poor working postures during morning care operations of ICU nurses.
Mechanism of Mettl14 regulating AIM2 inflammasome activation and neuronal apoptosis and pyroptosis in spinal cord injury by mediating PPARγ m6A methylation.
J Physiol Biochem
November 2024
Department of Neurological Rehabilitation, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuhan, Hubei, 430071, People's Republic of China.
Spinal cord injury (SCI) represents a destructive pathological and neurological state. Methyltransferase-like 14 (Mettl14)-mediated m6A modification links to spinal cord injury (SCI), and we explored its mechanism. SCI mouse models were subjected to si-Mettl14 and si-negative control treatments and mouse behavior, pathological condition and apoptosis assessments.
View Article and Find Full Text PDFYap1 alleviates sepsis associated encephalopathy by inhibiting hippocampus ferroptosis via maintaining mitochondrial dynamic homeostasis.
J Cell Mol Med
October 2024
Department of Anesthesiology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Article Synopsis
- - Sepsis-associated encephalopathy (SAE) leads to serious cognitive issues, and this study investigates if Yes-associated protein 1 (YAP1) can protect against SAE by targeting ferroptosis, a form of cell death linked to iron levels and lipid damage.
- - Experimental results showed that knocking out YAP1 in mice resulted in higher mortality and cognitive problems, demonstrated by various behavioral tests, while increased oxidative stress and inflammation were observed in their brains.
- - Overexpressing YAP1 in cell models helped reduce ferroptosis and improved mitochondrial function, suggesting that YAP1 plays a protective role by regulating mitochondrial dynamics and potentially reducing cognitive dysfunction in SAE.
Near-Infrared Activatable Copper Nanoplatforms Synergize with the 5-Azacytidine Prodrug to Potentiate Cuproptosis.
Angew Chem Int Ed Engl
December 2024
Department of Cardiology, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, China.
Cuproptosis, a newly discovered cell death modality, is gaining recognition for its crucial role in antitumor therapy. Here, we demonstrated that Ferredoxin 1 (FDX1), a key gene involved in cuproptosis, is negatively correlated with malignancy and T-cell exhaustion in head and neck squamous cell carcinoma (HNSCC). Based on these findings, we developed near-infrared (NIR) light-controlled nanoparticles (NPs), CuD@PM, which can selectively deliver copper to HNSCC cells and induce cuproptosis in the presence of microneedles loaded with triacetylated azacitidine (TAc-AzaC) and 808 nm laser irradiation.
View Article and Find Full Text PDFAutocatalytic DNA circuitries.
Chem Soc Rev
November 2024
Department of Chemistry, Center for Bioanalytical Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing 100084, China.
Article Synopsis
- * Recent advances focus on constructing these DNA circuits using biocatalysis and dynamic hybridization methods, enabling ultra-sensitive detection of important biological molecules like DNA, RNA, and proteins.
- * The review covers practical uses, challenges, and future directions of autocatalytic DNA circuits, emphasizing their role in bioanalysis and biomedical applications, as well as potential development into intricate DNA nanostructures.
Identification of crucial genes and possible molecular pathways associated with active vitamin D intervention in diabetic kidney disease.
Heliyon
October 2024
Department of Nephrology, Minda Hospital Affiliated to Hubei Minzu University, Hubei Clinical Research Center for Kidney Disease, Enshi, China.
Background: A significant cause of advanced renal failure is diabetic nephropathy (DKD), with few treatment options available. Calcitriol shows potential in addressing fibrosis related to DKD, though its molecular mechanisms remain poorly understood. This research seeks to pinpoint the crucial genes and pathways influenced by calcitriol within the scope of DKD-related fibrosis.
View Article and Find Full Text PDFDifferential involvement of central and peripheral catecholamines between Alzheimer's disease and vascular dementia.
Heliyon
October 2024
Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Donghu Road 169, Wuhan, 430071, Hubei, China.
Article Synopsis
- The study investigates the role of catecholamines (like dopamine and norepinephrine) in the development of Alzheimer's disease (AD) and vascular dementia (VaD) by analyzing their levels in animal models.
- Using specific mouse and rat models, researchers measured catecholamine concentrations in both blood and different brain areas to understand their distribution and expression during these neurodegenerative processes.
- Findings reveal that while catecholamines like dopamine are significant in AD, VaD is more associated with changes in the central noradrenergic system and increased serum catecholamines, suggesting different treatment approaches may be needed for each condition.
Insights Into Gastrointestinal Motility Through the Use of Optogenetic Sensors.
J Neurogastroenterol Motil
October 2024
Department of Gastroenterology and Hubei Provincial Center and Key Laboratory for the Intestinal and Colorectal Disease, Wuhan University Zhongnan Hospital, Wuhan, China.
A multifunctional self-reinforced injectable hydrogel for enhancing repair of infected bone defects by simultaneously targeting macrophages, bacteria, and bone marrow stromal cells.
Acta Biomater
November 2024
Hubei Key Laboratory of Natural Products Research and Development, China Three Gorges University, Yichang, 443002, China; College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang, 443002, China. Electronic address:
Article Synopsis
- Injectable hydrogels (IHs) can effectively promote the repair of infected bone defects, but challenges exist in providing antibacterial and osteo-inductive properties while maintaining mechanical integrity.
- The newly developed AOHA-RA/Lap nanocomposite IH utilizes two types of reversible cross-links for enhanced injectability and self-recovery, and it can release active compounds for over 10 days.
- In studies, this hydrogel showed strong antibacterial effects against common bacteria and effectively induced necessary immune responses and bone cell differentiation, significantly improving healing in infected bone defect models without major side effects.
Nrf2 mitigates sepsis-associated encephalopathy-induced hippocampus ferroptosis via modulating mitochondrial dynamic homeostasis.
Int Immunopharmacol
December 2024
Department of Anesthesiology, Zhongnan Hospital of Wuhan University, Wuhan, China; Hubei Provincial Engineering Research Center of Minimally Invasive Cardiovascular Surgery, Wuhan, China; Wuhan Clinical Research Center for Minimally Invasive Treatment of Structural Heart Disease, Wuhan, China. Electronic address:
Article Synopsis
- Sepsis-associated encephalopathy (SAE) leads to severe cognitive issues, and recent research indicates that ferroptosis, a type of cell death linked to iron and lipid processes, may be involved in SAE's effects on the brain.
- The study shows that knocking out the Nrf2 gene worsens cognitive and emotional impairments in a mouse model of SAE and promotes brain injury and ferroptosis by increasing oxidative stress and inflammatory markers.
- Overexpressing Nrf2 appears to protect against these effects by improving mitochondrial function and reducing neuroinflammation, suggesting that targeting Nrf2 could be a promising approach for treating cognitive dysfunction in SAE.
Preliminary study of the role of histone deacetylase (HDAC) in steroid-induced avascular necrosis of the femoral head induced by BMSC adipogenic differentiation.
J Orthop Surg Res
October 2024
Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Article Synopsis
- The research investigates the role of histone deacetylase 10 (HDAC10) in the adipogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and its implications for steroid-induced avascular necrosis of the femoral head (SANFH).
- Dexamethasone treatment was found to worsen the differentiation balance of BMSCs, with HDAC10 showing significantly reduced expression in adipogenic differentiation models.
- The study suggests that decreased HDAC10 levels lead to increased PPARγ expression, contributing to the progression of SANFH, and highlights potential therapeutic avenues for the condition.
Smart photonic crystal hydrogels for visual glucose monitoring in diabetic wound healing.
J Nanobiotechnology
October 2024
School of Power and Mechanical Engineering, The Institute of Technological Science, Wuhan University, Wuhan, 430072, China.
Article Synopsis
- Diabetes is a serious chronic disease characterized by high blood sugar levels, often leading to complications like diabetic wounds that have slow healing processes.
- The study developed hydrogels with different modules to monitor crucial physiological indicators (glucose, pH, temperature) in diabetic wounds more efficiently than traditional methods.
- The hydrogels use innovative materials to allow quick and visible changes in color to indicate levels of these biomarkers, significantly improving the monitoring and treatment of diabetic wounds.
Genetic architectures of the human hippocampus and those involved in neuropsychiatric traits.
BMC Med
October 2024
Department of Epidemiology and Biostatistics, School of Public Health, Wuhan University, Wuhan, 430071, China.
Article Synopsis
- The hippocampus is important for various neuropsychiatric traits, and understanding its subfields' genetic relationships is vital as it has high heritability and could serve as biomarkers for these conditions.
- Researchers examined MRI data from over 41,000 UK participants to conduct genome-wide association studies on 24 hippocampal and subfield volume traits and assessed their genetic correlations with 10 neuropsychiatric traits.
- They identified 352 genetic variants related to these traits and found specific genes associated with various conditions, concluding that changes in hippocampal structures are linked to an increased risk of Parkinson's disease.
Mechanism of nucleosomal H2A K13/15 monoubiquitination and adjacent dual monoubiquitination by RNF168.
Nat Chem Biol
October 2024
Institute of Translational Medicine, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.
Article Synopsis
- RNF168 is an important protein involved in DNA damage repair, specifically regulating how DNA is marked for repair by adding ubiquitin to certain sites on histone H2A.
- The study developed new chemical strategies and used cryo-electron microscopy to create detailed images of how RNF168 interacts with the E2 enzyme UbcH5c and nucleosomes during this process.
- It revealed a unique binding mode for RNF168 that differs from other E3 ligases, providing valuable insights into how this protein functions and how mutations may affect its role in DNA repair.
Bacterial and clinical metabolic signatures and their interactions in obese patients post-bariatric surgery.
BMC Gastroenterol
October 2024
Department of Hepatobiliary & Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, PR China.
Article Synopsis
- Obesity in China is linked to metabolic disorders, and Laparoscopic Sleeve Gastrectomy (LSG) is effective for weight loss and metabolic improvement, yet the impact on gut microbiota needs more study.
- A study with 30 obese patients showed significant weight loss and improvements in glucose metabolism and liver function six months after LSG, alongside changes in gut microbiota.
- The findings suggest that LSG alters gut microbiota, contributing to better metabolic health, emphasizing the importance of understanding these microbiota changes for optimizing treatment.
Bidirectional causality between micronutrients and mental illness: Mendelian randomization studies.
J Affect Disord
January 2025
Department of Pathology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address:
Article Synopsis
- This study investigates the causal relationship between 20 micronutrients and 7 psychiatric disorders using Mendelian randomization on data from over 7 million individuals.
- Results indicated specific associations, such as Vitamin D potentially lowering the risk of depression and carotene being linked to higher depression rates and other mood disorders.
- The findings suggest that certain micronutrient levels, like copper and magnesium, may influence mental health, highlighting the need for further exploration into dietary impacts on psychiatric conditions.
SOX17 Prevents Endothelial-Mesenchymal Transition of Pulmonary Arterial Endothelial Cells in Pulmonary Hypertension through Mediating TGF-β/Smad2/3 Signaling.
Am J Respir Cell Mol Biol
October 2024
Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College,, Hangzhou, China;
Article Synopsis
- Endothelial to mesenchymal transition (EndMT) contributes to pulmonary vascular remodeling in pulmonary hypertension (PH), with SOX17 playing a key role in maintaining vascular health through its interaction with exosomes.
- The study shows that decreased SOX17 expression in PH patients and models correlates with increased EndMT and activation of TGF-β/Smad2/3 signaling pathways.
- SOX17 can inhibit TGF-β-induced EndMT by suppressing ROCK1 expression, and its overexpression in specific rat models prevents pulmonary vascular remodeling, highlighting its potential as a therapeutic target in PH.
Deubiquitylase USP52 Promotes Bladder Cancer Progression by Modulating Ferroptosis through Stabilizing SLC7A11/xCT.
Adv Sci (Weinh)
December 2024
Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Bladder cancer (BLCA) is a prevalent cancer with high case-fatality rates and a substantial economic burden worldwide. Understanding its molecular underpinnings to guide clinical management is crucial. Ferroptosis, a recently described non-apoptotic form of cell death, is initiated by the lethal accumulation of iron-dependent lipid peroxidation products.
View Article and Find Full Text PDFDevelopment and validation of a multimodal deep learning framework for vascular cognitive impairment diagnosis.
iScience
October 2024
Department of Neurology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei province, China.
Article Synopsis
- Cerebrovascular disease (CVD) is a major cause of dementia, and detecting vascular cognitive impairment (VCI) in these patients is a significant challenge.
- Researchers analyzed clinical and neuroimaging data from 307 CVD subjects to create a multimodal deep learning model using vision transformer and extreme gradient boosting techniques.
- The hybrid model achieved strong performance, comparable to expert clinicians, and is capable of highlighting important brain regions and clinical features that aid in the diagnosis of VCI, making it a valuable tool for clinical decision support.