3 results match your criteria: "Zhongnan Hosipital of Wuhan University[Affiliation]"
APEX1 regulates alternative splicing of key tumorigenesis genes in non-small-cell lung cancer.
BMC Med Genomics
July 2022
Department of Internal Medicine and Geriatrics, Zhongnan Hospital of Wuhan University, Wuhan University, No. 169 Dong Hu Road, Wuhan, 430071, Hubei, China.
Background: Aberrant alternative splicing (AS) contributes to tumor progression. Previous studies have shown that apurinic-apyrimidinic endonuclease-1 (APEX1) is involved in tumor progression. It is unknown whether APEX1 functions in tumor progression by regulation of AS.
View Article and Find Full Text PDFEstablishing a new human hypertrophic cardiomyopathy-specific model using human embryonic stem cells.
Exp Cell Res
February 2020
Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China. Electronic address:
Symptom of ventricular hypertrophy caused by cardiac troponin T (TNNT2) mutations is mild, while patients often showed high incidence of sudden cardiac death. The 92nd arginine to glutamine mutation (R92Q) of cTnT was one of the mutant hotspots in hypertrophic cardiomyopathy (HCM). However, there are no such human disease models yet.
View Article and Find Full Text PDF[Use of antiperistaltic cecoproctostomy in colorectal reconstruction].
Zhonghua Wei Chang Wai Ke Za Zhi
June 2011
Department of Colorectal Surgery, Zhongnan Hosipital of Wuhan University, Wuhan, China.
Objective: To explore the feasibility and functional outcome of antiperistaltic cecoproctostomy in colorectal reconstruction.
Methods: Fifty-six patients who underwent antiperistaltic cecoproctostomy were retrospectively studied. Indications for antiperistaltic cecoproctostomy included slow transit constipation(n=44), synchronous colon cancer or colonic polyps(n=5), acute obstructing left colon carcinoma(n=4), and adult megacolon(n=3).