Cardiac fibroblast-derived mitochondria-enriched sEVs regulate tissue inflammation and ventricular remodeling post-myocardial infarction through NLRP3 pathway.

Resident cardiac fibroblasts (CFs) play crucial roles in sensing injury signals and regulating inflammatory responses post-myocardial infarction (MI). Damaged mitochondria can be transferred extracellularly via various mechanisms, including extracellular vesicles (EVs). In this study, we aimed to investigate whether CFs could transfer damaged mitochondrial components via small EVs (sEVs) and elucidate their role in regulating inflammatory responses post-MI.

The role of artificial intelligence in aortic valve stenosis: a bibliometric analysis.

Purpose: To explore the expanding role of artificial intelligence (AI) in managing aortic valve stenosis (AVS) by bibliometric analysis to identify research trends, key contributors, and the impact of AI on enhancing diagnostic and therapeutic strategies for AVS.

Methods: A comprehensive literature review was conducted using the Web of Science database, covering publications from January 1990 to March 2024. Articles were analyzed with bibliometric tools such as CiteSpace and VOSviewer to identify key research trends, core authors, institutions, and research hotspots in AI applications for AVS.

DDX59-AS1: A Novel Prognostic Biomarker and Immunotherapy Predictor in Lung Adenocarcinoma.

Background: The precise function of DDX59 Antisense RNA 1 (DDX59- AS1) in lung adenocarcinoma (LUAD) has yet to be fully elucidated.

Objective: This study uses bioinformatics analysis and experimental validation to investigate the association between DDX59-AS1 and LUAD.

Methods: This study uses statistical analysis and database interrogation to investigate the potential association between DDX59-AS1 expression and various clinical characteristics, prognostic factors, regulatory networks, and immune infiltration in LUAD.

Exploration of key pathogenic mechanisms and potential intervention targets of the traditional Chinese medicine Coptis chinensis in the treatment of cervical cancer based on network pharmacology and molecular docking techniques.

Background: Traditional Chinese medicine (TCM) has shown potential in the treatment of cancer. This study investigated the molecular targets and mechanisms of Coptis chinensis in the treatment of cervical cancer using network pharmacology and bioinformatics.

Methods: Effective Coptis chinensis components were screened from the Traditional Chinese Medicine Systems Pharmacology (TCMSP) platform based on the following criteria: drug-like properties (DLP) ≥0.

Association of red blood cell distribution width-coefficient of variation with cranial ultrasound abnormalities in neonatal hyperbilirubinemia: a retrospective cross-sectional study.

Background: Neonatal hyperbilirubinemia frequently leads to severe neurological damage. Although cranial ultrasound (CUS) is crucial for assessing neonatal brain injury, the association between red blood cell distribution width-coefficient of variation (RDW-CV), a marker of red blood cell size variability, and cranial ultrasound abnormalities (CUAs) remains unclear.

Objective: The primary aim of this study was to explore the impact of RDW-CV on CUAs in neonatal hyperbilirubinemia and to elucidate the potential clinical implications of this relationship.

Evaluation of the causal effects of perfluorooctanesulfonate on COVID-19 and its associated mechanisms: Integrated Mendelian randomization and network toxicology analyses.

Observational reports have suggested that exposure to perfluorooctanesulfonate (PFOS) can influence COVID-19 infection-related parameters. This study thus sought to use integrated Mendelian randomization (MR) and network toxicology approaches to clarify the potential causal link between PFOS exposure and COVID-19 severity and the molecular mechanisms underlying this relationship. Inverse-variance-weighted analyses highlighted a causal link between plasma PFOS concentrations and a greater risk of sCOVID-19 (OR 1.

Outcomes and risk factors of transported patients with extracorporeal membrane oxygenation: An ECMO center experience.

Background: Extracorporeal membrane oxygenation (ECMO) has been proven to be a support method and technology for patients with cardiopulmonary failure. However, the transport of patients under ECMO support is challenging given the high-risk technical maneuvers and patient-care concerns involved. Herein, we examined the safety of ECMO during the transport of critically ill patients and its impact on mortality rates, to provide more secure and effective transport strategies in clinical practice.

The relationship between cardiometabolic Index and diabetic kidney disease in people with diabetes.

Introduction: Studies have shown a strong correlation between the cardiometabolic index (CMI) and health issues such as diabetes, atherosclerosis, and decreased renal function. Nevertheless, the correlation between CMI and diabetic kidney disease (DKD) remains ambiguous. The objective of this study is to evaluate the correlation between CMI and DKD in patients with diabetes in the United States.

Silibinin alleviates acute liver failure by modulating AKT/GSK3β/Nrf2/GPX4 pathway.

Silibinin (Sil) is a major bioactive component of silymarin, extracted from the fruit and seeds of Silybum marianum. Silibinin meglumine (SM) is a water-soluble derivative of silibinin that has shown significant potential in liver fibrosis. However, the potential effects and underlying mechanisms of SM on acute liver failure (ALF) are still not fully understood.

Severe liver injury induced by minocycline in hepatitis B patient: a Case Report.

Physical liver injury is an acute and potentially serious adverse event that may result in acute liver failure or even death. Diagnosis is often challenging. Minocycline, a semi-synthetic second-generation tetracycline, has high fat solubility and good tissue permeability.

Association between weight loss and survival outcomes in patients with gastric cancer: a meta-analysis.

Patients with gastric cancer often experience weight loss. A meta-analysis was conducted to evaluate the association between weight loss and survival outcomes in gastric cancer patients. We searched PubMed, Embase, and Web of Science according to the PECOS criteria: population (gastric cancer patients), exposure (weight loss), comparator (weight stable), outcomes [overall survival (OS) or recurrence-free survival], and study design (cohort studies).

Leukopenia-a rare complication secondary to invasive liver abscess syndrome in a patient with diabetes mellitus: A case report.

Background: Thrombocytopenia is a common complication of invasive liver abscess syndrome (ILAS) by () infection, which indicates severe infection and a poor prognosis. However, the presence of leukopenia is rare. There are rare reports on leukopenia and its clinical significance for ILAS, and there is currently no recognized treatment plan.

The causal association between COVID-19 and ischemic stroke: a mendelian randomization study.

Background: Current observational data indicates that ischemic stroke (IS) affects a significant proportion of people with COVID-19. The current study sought to evaluate the causal relationship between COVID-19 and IS.

Methods: A two-sample Mendelian randomization (2 S-MR) approach was used to probe the relationship between genetic determinants of three COVID-19 parameters (SARS-CoV-2 infection, COVID-19 hospitalization, and severe COVID-19) and the incidence of IS based on genome-wide association studies (GWAS) data.

Gut microbiota modulating therapy for diabetes mellitus should be individualized.

In this editorial, we commented on two articles published online in August and September 2024 in the , which focused on modifying the gut microbiota (GM) to prevent or delay the progression of diabetes mellitus (DM) and DM-related complications. Numerous studies, many of which are animal studies, have indicated the potential role of GM in the pathogenesis of DM. However, the detailed causality and mechanisms between GM and DM have not been fully clarified.

An unexpected retained metallic intraocular foreign body.

Purpose: This case report aims to describe a rare case of asymptomatic retained metallic intraocular foreign body (IOFB) in the retina with reduced full-field electroretinography (ff-ERG) in a Chinese woman.

Methods: This is a clinical investigation of a patient who unexpectedly presented with a metallic IOFB at the superior-temporal region of the left eye ring during a brain computed tomography.

Results: Her best-corrected visual acuity was 20/20 in both eyes.

A [F]FDG PET based nomogram to predict cancer-associated cachexia and survival outcome: A multi-center study.

Objectives: Cancer patients with cachexia face poor prognosis and shortened survival. Early diagnosis and accurate prognosis prediction remain challenging. This multi-center study aims to develop and externally validate a nomogram integrating [F]fluoro-2-deoxy-D-glucose ([F]FDG) PET findings and routine clinical biochemistry tests for predicting cancer-associated cachexia, while also assessing its potential prognostic value.