8 results match your criteria: "Zhengzhou Universitygrid.207374.5[Affiliation]"

Bluetongue (BT) is a severe noncontagious infectious disease that occurs in sheep and wild ruminants but occasionally also in cattle and camels. The worldwide BT pandemic has had a significant impact on global livestock production. Rapid detection helps prevent outbreaks of bluetongue disease.

View Article and Find Full Text PDF

Coxsackievirus A2 (CVA2) is an emerging pathogen that results in hand-foot-and-mouth disease (HFMD) outbreaks. Systemic inflammatory response and central nervous system inflammation are the main pathological features of fatal HFMD. However, the immunopathogenesis of CVA2 infection is poorly understood.

View Article and Find Full Text PDF

Identification and Functional Analysis of a Novel Hydrophobic Protein VdHP1 from Verticillium dahliae.

Microbiol Spectr

April 2022

Zhengzhou Research Base, State Key Laboratory of Cotton Biology, School of Agricultural Sciences, Zhengzhou Universitygrid.207374.5, Henan, Zhengzhou, China.

Verticillium dahliae could cause destructive vascular wilt disease on hundreds of plant species around the world, including cotton. In this study, we characterized the function of a hydrophobin gene in pathogen development and pathogenicity. Results showed that could induce cell death and activate plant immune responses.

View Article and Find Full Text PDF

The CD2-like (CD2V) protein is a crucial antigen of African swine fever virus (ASFV). CD2V interacts with the cellular AP-1 protein, participates in intracellular transport of virus, and induces neutralizing antibodies to partly protect swine from virus attack. In this study, a specific CD2V dimeric protein was designed to enhance antigenicity and immunogenicity, expressed in a Bac-to-Bac baculovirus expression vector system and purified by Ni-affinity chromatography.

View Article and Find Full Text PDF

Genomic Epidemiology Insights on NDM-Producing Pathogens Revealed the Pivotal Role of Plasmids on Transmission.

Microbiol Spectr

April 2022

School of Pharmaceutical Sciences, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou Universitygrid.207374.5, Zhengzhou, Henan, China.

Article Synopsis
  • A global increase in nosocomial infections caused by New Delhi metallo-β-lactamase (NDM) enzyme-producing bacteria poses a significant public health threat.
  • During a study in Henan, China, 81 NDM-producing strains were identified from 391 carbapenem-resistant Enterobacteriaceae (CRE) between 2013 and 2016, with E. coli being the most common.
  • The research uncovered genetic characteristics, including the presence of various plasmids and co-carriage of multiple resistance genes, which help understand the transmission and evolution of these dangerous bacteria.
View Article and Find Full Text PDF

Shiga toxin-producing Escherichia coli (STEC) O26 is the predominant non-O157 serogroup causing hemolytic uremic syndrome worldwide. Moreover, the serogroup is highly dynamic and harbors several pathogenic clones. Here, we investigated the phylogenetic relationship of STEC O26 at a global level based on 1,367 strains from 20 countries deposited in NCBI and Enterobase databases.

View Article and Find Full Text PDF

Tigecycline is regarded as one of the few important last-resort antibiotics to treat complicated skin and intra-abdominal infections. Members of the genus Staphylococcus are zoonotic pathogens and pose a serious threat to public health. Tigecycline resistance in this species appears to be a rare phenomenon, and the mechanisms underlying tigecycline resistance have not been fully elucidated.

View Article and Find Full Text PDF

Plasmids Shape the Current Prevalence of among Klebsiella pneumoniae in Food Production Chains.

mSystems

October 2021

College of Veterinary Medicine, Yangzhou Universitygrid.268415.c, Yangzhou, Jiangsu Province, People's Republic of China.

The emergence of novel antimicrobial resistance genes conferring resistance to last-resort antimicrobials poses a serious challenge to global public health security. Recently, one plasmid-mediated RND family multidrug resistance efflux pump gene cluster named , which confers resistance to tigecycline, was identified in bacteria of animal and human origins. However, the comprehensive landscape of the genomic epidemiology of this novel resistance determinant remained unclear.

View Article and Find Full Text PDF