Characteristics, polarization and targeted therapy of mononuclear macrophages in rheumatoid arthritis.

Macrophages are the core of the pathophysiology of rheumatoid arthritis (RA). They participate in specific and non-specific immunological responses, have phagocytosis, chemotaxis and immune regulatory functions, and are involved in the onset and progression of RA. In recent years, research on the pathophysiology of RA has focused on the polarization and functions of classically activated M1 and selectively activated M2 macrophage subtypes.

An ICT-based fluorescence enhancement probe for detection of Sn in cancer cells.

Development of a novel fluorescence enhancement probe for detection of Sn in organisms, with high selectivity and sensitivity, is of great interest but remains a great challenge. Herein, an ICT-based fluorescence probe TPPB was rationally developed to act as an 'enhancement' luminescent and "naked-eye" indicator for Sn detection. Importantly, spectroscopic studies indicated that TPPB was a fluorescence enhancement sensor for Sn with rapid response, low detection limit (0.

miR-let-7d attenuates EMT by targeting HMGA2 in silica-induced pulmonary fibrosis.

Silicosis is a serious occupational disease characterized by pulmonary chronic inflammation and progressive fibrosis. Epithelial-mesenchymal transition (EMT) of alveolar epithelial cells plays a vital role in silicosis. Recent studies discovered a variety of microRNAs (miRNAs) participating in fibrotic diseases.

Electrochemical sensor based on a three dimensional nanostructured MoS nanosphere-PANI/reduced graphene oxide composite for simultaneous detection of ascorbic acid, dopamine, and uric acid.

A three dimensional (3D) nanostructured composite based on the self-assembly of MoS nanospheres and polyaniline (PANI) loaded on reduced graphene oxide (denoted by 3D MoS-PANI/rGO) was prepared a feasible one-pot hydrothermal process. The 3D MoS-PANI/rGO nanocomposite not only exhibits good functionality and bioaffinity but also displays high electrochemical catalytic activity. As such, the developed 3D MoS-PANI/rGO nanocomposite can be employed as the sensing platform for simultaneously detecting small biomolecules, , ascorbic acid (AA), dopamine (DA), and uric acid (UA).

Dendritic cells trigger imbalance of Th1/Th2 cells in silica dust exposure rat model MHC-II, CD80, CD86 and IL-12.

Silicosis is one of the most common occupational respiratory diseases caused by inhaling silica dust over a prolonged period of time, and the progression of silicosis is accompanied with chronic inflammation and progressive pulmonary fibrosis, in which dendritic cells (DCs), the most powerful antigen presentation cell (APC) in the immune response, play a crucial role. To investigate the role of DCs in the development of silicosis, we established an experimental silicosis rat model and examined the number of DCs and alveolar macrophages (AMs) in lung tissues using immunofluorescence over 84 days. Additionally, to obtain an overview of the immunological changes in rat lung tissues, a series of indicators including Th1/Th2 cells, IFN-γ, IL-4, MHC-II, CD80/86 and IL-12 were detected using flow cytometry and an enzyme-linked immunosorbent assay (ELISA) as well as a real-time polymerase chain reaction (PCR) assay.