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Histone Modifications Regulate the Developmental Expression of Human Hepatic UDP-Glucuronosyltransferase 1A1.

Drug Metab Dispos

December 2017

Department of Pharmacology, School of Basic Medicine, Zhengzhou University (Y.-L.N., J.-Y.L., L.Y., P.W., H.-Z.B., L.-R.Z.); Laboratory of Cardiovascular Disease and Drug Research, Seventh People's Hospital of Zhengzhou (X.-G.M.); Department of Clinical Pharmacology, First Affiliated Hospital, Zhengzhou University (Q.-C.K.), Zhengzhou, People's Republic of China

Human UDP-glucuronosyltransferase 1A1 (UGT1A1) is a unique enzyme involved in bilirubin conjugation. We previously characterized the hepatic expression of transcription factors affecting UGT1A1 expression during development. Accordingly, in this study, we characterized the ontogenetic expression of hepatic UGT1A1 from the perspective of epigenetic regulation.

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