49,380 results match your criteria: "Zhengzhou University[Affiliation]"
JCO Precis Oncol
January 2025
Ge Zhang, MD, PhD, Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China, Henan Key Laboratory of Chronic Disease Prevention and Therapy & Intelligent Health Management, Zhengzhou, Henan, China, Tianjian Laboratory of Advanced Biomedical Sciences, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China; Shiqian Zhang, MD, PhD, Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China; Haonan Zhang, MD, PhD, Department of Thyroid Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Ruhao Wu, MD, PhD, Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China; and Haoze Zheng, MD, PhD, Academy of Interdisciplinary Studies, Hong Kong University of Science and Technology, Hong Kong, China.
Transgenic Res
January 2025
Shaanxi Tobacco Company Baoji City Company, Baoji, 721000, Shaanxi, China.
The involvement of Loose Plant Architecture 1 (LPA1) in regulating plant growth and leaf angle has been previously demonstrated. However, the fundamental genetic background remains unidentified. To further understand the tissue expression profile of the NtLPA1 gene, an overexpression vector (pBI121-NtLPA1) was developed and employed to modify tobacco using the leaf disc method genetically.
View Article and Find Full Text PDFAnal Chem
January 2025
Henan Key Laboratory of Biomolecular Recognition and Sensing, Henan Joint International Research Laboratory of Chemo/Biosensing and Early Diagnosis of Major Diseases, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000, China.
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons and the accumulation of alpha-synuclein. Glutathione (GSH), a key antioxidant, is significantly depleted in PD patients. This study presents a dual-mode detection strategy for selectively determining GSH using a single probe.
View Article and Find Full Text PDFMol Carcinog
January 2025
Department of Neurosurgery, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, The People's Republic of China.
RNF7 (Ring Finger Protein 7) is a key component of CRLs (Cullin-RING-type E3 ubiquitin ligases) and has been found to possess intrinsic anti-ROS capabilities. Aberrant expression of RNF7 has been observed in various tumor types and is known to significantly influence tumor initiation and progression. However, the specific role of RNF7 in glioblastoma remains unclear.
View Article and Find Full Text PDFHaematologica
January 2025
State Key Laboratory of Genetic Engineering, Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Shanghai Xuhui Central Hospital / Zhongshan-Xuhui Hospital, Fudan University, Shanghai.
Not available.
View Article and Find Full Text PDFInt J Med Sci
January 2025
Department of Laboratory Medicine, Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
While NUSAP1's association with various tumors is established, its predictive value for prognosis and immunotherapy in lung adenocarcinoma (LUAD) remains unconfirmed. We analyzed Nucleolar Spindle-Associated Protein 1 (NUSAP1) gene expression in TCGA and GTEx datasets and validated it in clinicopathological tissues using qRT-PCR and immunohistochemistry. Additionally, we investigated NUSAP1's relationship with patient prognosis across TCGA and five GEO cohorts.
View Article and Find Full Text PDFExp Ther Med
February 2025
Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450001, P.R. China.
Warfarin is a commonly employed anticoagulant drug aimed at rapidly reaching the optimal international normalized ratio (INR), potentially reducing the hospitalization time in clinical settings. However, limited research has been conducted on the influencing factors and the safety implications of promptly reaching the target INR range in patients with valvular heart disease who have undergone valve replacement or repair. The present study aimed to assess the factors related to the safety considerations of rapidly reaching the target INR range in patients treated with warfarin.
View Article and Find Full Text PDFCardiovasc Res
January 2025
State Key Laboratory of Cardiovascular Disease, Clinical Pharmacology Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
Aims: The therapeutic efficacy of coronary revascularization is compromised by myocardial ischemia-reperfusion (MI/R) injury. Higher levels of circulating arachidonic acid (AA) are reportedly associated with lower risk of cardiovascular disease. The cyclooxygenase (COX) pathway metabolizes AA into prostaglandins (PGs) and the platelet-activating thromboxane A2 (TXA2), which is inhibited by aspirin.
View Article and Find Full Text PDFZhonghua Wei Zhong Bing Ji Jiu Yi Xue
December 2024
Department of Public Utilities Development, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou 450003, Henan, China.
Objective: To explore the effects of veno-venous extra corporeal carbon dioxide removal (V-V ECCOR) on local mechanical power and gas distribution in the lungs of patients with mild to moderate acute respiratory distress syndrome (ARDS) receiving non-invasive ventilation.
Methods: Retrospective research methods were conducted. Sixty patients with mild to moderate ARDS complicated with renal insufficiency who were transferred to the respiratory intensive care unit (RICU) through the 96195 platform critical care transport green channel from January 2018 to January 2020 at the collaborative hospitals of Henan Provincial People's Hospital were enrolled.
Cardiovasc Diabetol
January 2025
Department of Emergency Intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, No.1st, Jian She Eastern Road, Zhengzhou, 450052, Henan Province, People's Republic of China.
Chronic heart failure (CHF) poses a significant threat to human health. The stress hyperglycemia ratio (SHR) is a novel metric for accurately assessing stress hyperglycemia, which has been correlated with adverse outcomes in various major diseases. However, it remains unclear whether SHR is associated with 28-day mortality in patients with pre-existing CHF who were admitted to intensive care units (ICUs).
View Article and Find Full Text PDFCell Commun Signal
January 2025
School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China.
Background: Staphylococcus aureus, a known contributor to non-healing wounds, releases vesicles (SAVs) that influence the delicate balance of host-pathogen interactions. Efferocytosis, a process by which macrophages clear apoptotic cells, plays a key role in successful wound healing. However, the precise impact of SAVs on wound repair and efferocytosis remains unknown.
View Article and Find Full Text PDFInt J Equity Health
January 2025
National Engineering Laboratory for Internet Medical Systems and Applications, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe Road, Erqi District, Zhengzhou, Henan, 450052, China.
Background: Ensuring vaccine access is a prerequisite for promoting human papilloma virus (HPV) vaccination. Although HPV vaccination efforts in China have primarily focused on young females, little research has examined the difficulties they face in accessing the HPV vaccine and its impact on vaccine uptake and intention. This study analyzed the overall perception of access difficulties to HPV vaccines, as well as three specific vaccine access difficulties, and examined their influencing factors among female university students in China.
View Article and Find Full Text PDFBMC Med
January 2025
Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China.
Background: The heterogeneity of cognitive impairments in schizophrenia has been widely observed. However, reliable cognitive boundaries to differentiate the subgroups remain elusive. The key challenge for cognitive subtyping is applying an integrated and standardized cognitive assessment and understanding the subgroup-specific neurobiological mechanisms.
View Article and Find Full Text PDFBMC Med Imaging
January 2025
Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Purpose: We used knowledge discovery from radiomics of T2-weighted imaging (T2WI) and contrast-enhanced T1-weighted imaging (T1C) for assessing relapse risk in patients with high-grade meningiomas (HGMs).
Methods: 279 features were extracted from each ROI including 9 histogram features, 220 Gy-level co-occurrence matrix features, 20 Gy-level run-length matrix features, 5 auto-regressive model features, 20 wavelets transform features and 5 absolute gradient statistics features. The datasets were randomly divided into two groups, the training set (~ 70%) and the test set (~ 30%).
Sci Rep
January 2025
Department of Neurology, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe Dong Road, Zhengzhou, Henan, China.
Parkinson's disease (PD) and insomnia are prevalent neurological disorders, with emerging evidence implicating tryptophan (TRP) metabolism in their pathogenesis. However, the precise mechanisms by which TRP metabolism contributes to these conditions remain insufficiently elucidated. This study explores shared tryptophan metabolism-related genes (TMRGs) and molecular mechanisms underlying PD and insomnia, aiming to provide insights into their shared pathogenesis.
View Article and Find Full Text PDFNat Commun
January 2025
Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chemical Biology Research Center, School of Pharmaceutical Sciences, Chongqing University, Chongqing, China.
Helicene-shaped molecules are compelling chemical structures with unique twisted helical chirality and remarkable properties. Although progress occurs in the catalytic asymmetric synthesis of helicene (-like) molecules, the enantioselective synthesis of multiple helicenes, especially four or higher helicity, is still challenging and has yet to be achieved. Herein, we report an organocatalytic [4 + 2] cycloadditions to achieve double S-shaped quadruple helicene-like molecules with high enantioselectivity (up to 96% e.
View Article and Find Full Text PDFZhonghua Yi Xue Yi Chuan Xue Za Zhi
January 2025
Department of Clinical Laboratory, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou Key Laboratory of Children's Infection and Immunity, Zhengzhou, Henan 450018, China.
Objective: To explore the clinical features of a child with Lamb-Shaffer syndrome (LAMSHF) due to a variant of SOX5 gene.
Methods: A child who was admitted to Children's Hospital Affiliated to Zhengzhou University in July 2022 was selected as the study subject. Clinical data of the child was collected.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
January 2025
Department of Digestive Disease, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, Henan 450018, China.
Objective: To explore the clinical features and genetic characteristics of three patients with Infantile liver failure syndrome type 2 (ILFS2).
Methods: Three children who were diagnosed with ILFS2 at the Children's Hospital Affiliated to Zhengzhou University from February 2023 to February 2024 were selected as the study subjects. Clinical data of the children were collected.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
October 2025
Department of Pediatric Neurology, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Objective: To explore the clinical and genetic characteristics of two children diagnosed with two rare genetic diseases simultaneously.
Methods: Two children with comorbidity of two genetic diseases due to dual genetic mutations diagnosed at the Third Affiliated Hospital of Zhengzhou University respectively in May 2022 and March 2023 were selected as the study subjects. Clinical and genetic data of the two children were retrospectively analyzed.
Carbohydr Polym
March 2025
College of Chemistry, Zhengzhou University, Zhengzhou 450000, China. Electronic address:
Soft actuators for intelligent robots require further elaboration to improve their biomedical applicability, which has led to the development of a series of flexible stimulus-responsive materials. However, fabricating degradable soft actuators that exhibit synergistic color and shape changes in response to environmental stimuli remains challenging. Here, we developed a soft actuating gel based on carbon dots (CDs) that are chemically cross-linked with sodium alginate.
View Article and Find Full Text PDFJ Neurointerv Surg
January 2025
Department of Cerebrovascular Disease, Zhengzhou University People's Hospital, Henan Provincial People's Hospital; Henan Provincial Cerebrovascular Interventional Innovation Engineering Technology Research Center, Henan International Joint Laboratory of Cerebrovascular Disease, Zhengzhou, Henan, China
Objective: This study aimed to examine the effect of drug-coated balloons (DCBs) on vascular luminal dilatational remodeling (VLDR) following simple balloon angioplasty.
Methods: A retrospective cohort study was conducted using data from patients diagnosed with intracranial atherosclerotic stenosis (ICAS), who were treated exclusively with balloon angioplasty at Henan Provincial People's Hospital between June 2019 and April 2023. Inverse probability weighting (IPW) was used to create balanced cohorts of patients who underwent drug-coated balloon angioplasty (DCBA) and plain old balloon angioplasty (POBA).
Int J Biol Macromol
January 2025
Zhongyuan Critical Metals Laboratory, Zhengzhou University, Zhengzhou, Henan 450001, PR China; School of Chemical Engineering, Zhengzhou University, Zhengzhou, Henan 450001, PR China; Luoyang Industrial Technology Institute, Luoyang, Henan 471132, PR China; The Key Lab of Critical Metals Minerals Supernormal Enrichment and Extraction, Ministry of Education, Zhengzhou, Henan 450001, PR China.
An efficient adsorbent for Ga(III) recovery was developed by applying the geochemical principles of Ga mineralization, using Al-rich clay minerals with a natural affinity for Ga as the raw material. Sodium alginate (SA) facilitated the cross-linked assembly of montmorillonite nanosheets (MMTNS), forming a three-dimensional structured hydrogel. This was achieved through electrostatic interactions between -OH groups on the edges of MMTNS and -COO groups in SA, as well as the complexation of Ca and -COO groups.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
Northwest A&F University, College of Food Science and Engineering, Yangling, Shanxi 712100, China; School of Food Science, Henan Institute of Science and Technology, 90 Eastern Hualan Avenue, Xinxiang 453003, China. Electronic address:
The effects of sugar boiling pretreatment (SBP) with different maltitol concentrations (20 %, 30 %, and 40 %) and boiling time (0 - 6 min) on the physicochemical and functional properties of purple sweet potato flour and the radiofrequency explosion puffing (RFEP) quality were investigated. The results showed that the volume ratio, crispness, anthocyanin retention rate and overall acceptability of the samples were maximized after boiling for 6 min at 40 % maltitol concentration achieving increases of 78.63 %, 437.
View Article and Find Full Text PDFTalanta
January 2025
Ministry of Education (MOE) Key Laboratory of Bioinorganic and Synthetic Chemistry, Ministry of Education, School of Chemistry, Sun Yat-sen University, Guangzhou, 510006, PR China; School of Chemical Engineering and Technology, Sun Yat-sen University, and Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), 519082, Zhuhai, PR China; Guangdong Provincial Key Laboratory of Emergency Test for Dangerous Chemicals, Guangdong Provincial Engineering Research Center for Ambient Mass Spectrometry, Institute of Analysis, Guangdong Academy of Sciences (China National Analytical Center Guangzhou), 100 Xianlie Middle Road, Guangzhou, 510070, PR China; Chemistry College, Center of Advanced Analysis and Gene Sequencing, Zhengzhou University, Kexue Avenue 100, Zhengzhou, 450001, PR China.
Macrocyclic polymer materials exhibit excellent selectivity and adsorption performance in pollutant adsorption due to unique host-guest recognition. Herein, three kinds of calixarene polymers (C4P, C6P and C8P) were synthesized through Sonogashira reaction, and were characterized through H NMR, FT-IR, SEM, and TEM. The water contact angle experiments revealed that three kinds of calixarene polymers were highly hydrophobic, and they all exhibited high enrichment efficiency for weak polar chloro-substituted benzene compounds (chlorobenzene, o-chlorotoluene, p-dichlorobenzene and o-dichlorobenzene) and BTEX (benzene, toluene, ethylbenzene and xylenes).
View Article and Find Full Text PDFEcotoxicol Environ Saf
January 2025
State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University, 999077, Hong Kong SAR.
p-Phenylenediamine (PPD) antioxidants and their quinone derivatives (PPDQs), as hot-spot novel contaminants in recent years, have been detected in air fine particulate matters (PM) in multiple regions. However, current research all discussed the pollution of PPDs and PPDQs based on the collected PM samples at least in one day (23.5 h).
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