Exploring a recurrence model for atypical meningioma based on multiparametric MRI radiomic and clinical characteristics: a multicenter retrospective cohort study.

Objectives: Atypical meningioma (AM) has a high recurrence rate. This study explored the factors associated with recurrence and built a predictive model for AM by combining radiomic and clinical features.

Methods: This retrospective cohort study enrolled 451 adult AM patients who underwent surgical treatment at three institutions between May 2012 and April 2024.

Motor developmental delay in preschoolers with autism spectrum disorders in China and its association with core symptoms and maternal risk factors: a multi-center survey.

Background: Motor disturbance, as a related symptom of autism spectrum disorders (ASD), has not received the attention it deserves. We aimed to investigate the different degrees of motor developmental delay and influencing factors in Chinese preschool children with ASD, in order to enhance people's awareness of motor developmental delay in ASD children.

Methods: We recruited 1,256 ASD children aged 2-6 years from the China Multi-Center Preschool Autism Project (CMPAP).

Frailty mediated the associations of fine particulate matter with depression and anxiety: Findings from the UK Biobank.

Background: The role of frailty in the associations of fine particulate matter (PM2.5) with depression and anxiety was unknown.

Methods: This study is a longitudinal population-based cohort study.

Threshold size criterion to suspect malignant supraclavicular lymph node < 10 mm in esophageal cancer.

Objectives: To determine the threshold size for predicting metastasis of supraclavicular lymph nodes (SCLNs) < 10 mm on axial and multiplanar reconstruction CT in esophageal squamous cell carcinoma (ESCC).

Methods: This retrospective, multicenter study received approval from three institutional review boards, which waived informed consent. Patients with ESCC had ultrasound-guided fine-needle aspiration biopsy (US-FNAB) for SCLNs, with contrast-enhanced CT performed within 2 weeks prior to US-FNAB.

Stroke Mechanisms in Intracranial Atherosclerotic Disease: A Modified Classification System and Clinical Implications.

Background: In patients with symptomatic intracranial atherosclerotic stenosis (sICAS), recent evidence has suggested an association between artery-to-artery embolism (AAE) and cortical borderzone (CBZ) infarcts.

Methods: We recruited patients with 50-99% anterior-circulation sICAS in this cohort. Stroke mechanisms were categorized as isolated parent artery atherosclerosis occluding penetrating artery (PAO), isolated AAE, isolated hypoperfusion, and mixed mechanisms, using two classification systems.

Label-free electrochemical biosensor based on AuNPs and PCL-b-PHEAA amphiphilic copolymer for highly sensitive detection of CEA.

Carcinoembryonic antigen (CEA) is a broad-spectrum tumor marker expressed in various human cancers. In this study, the electrode loaded with AuNPs was used to replace the traditional electrode, providing more active sites for biological probes and significantly enhancing the sensitivity of the sensor. By constructing an aptamer-antigen-aptamer "sandwich structure," highly selective detection was achieved, effectively avoiding cross-reactions.

Influence of soil-rock composite stratum on mechanical response and failure modes of underground utility tunnel.

This research combines scaled model experiments with theoretical analysis to investigate the impact of underground utility tunnels (UUTs) on foundation bearing capacity and to examine the interaction between soil-rock composite strata and the stress-strain responses of the tunnel. The findings indicate that UUTs alter the foundation mechanism by reducing soil depth, streamlining the load transfer path, and causing stress to converge at the tunnel's top. Additionally, the results reveal that the influence range of the tunnel on both sides is approximately 1.

A safety risk assessment method for TBM tunnel construction based on attribute interval identification theory.

Based on the identification and analysis of safety risks in TBM tunnel construction, we construct a comprehensive safety risk dynamic evaluation index system tailored to this context. To account for the dynamic nature of safety risks during TBM tunnel construction, variable weight theory is incorporated, allowing for a more accurate reflection of the time-varying importance of risk indicators. Building on the theoretical framework of attribute interval recognition theory, we establish a TBM tunnel construction safety risk evaluation model grounded in attribute interval theory.

Post-cardiovascular disease healthy lifestyle, inflammation and metabolic biomarkers, and risk of dementia: a population-based longitudinal study.

Background: Cardiovascular disease (CVD) is associated with an increased risk of dementia, but the impact of healthy lifestyle on post-CVD dementia remains unclear.

Objectives: The aim of this study was to explore the association between post-CVD healthy lifestyle factors and risk of dementia. We further examined whether inflammation and metabolic biomarkers played a role in this association.

Status and factors influencing health-related quality of life in patients with non-alcoholic fatty liver disease in Hangzhou: a cross-sectional study.

Objective: Due to rapid economic development and the unique lifestyles, cultures and customs of Hangzhou, non-alcoholic fatty liver disease (NAFLD) has attracted widespread attention, with a prevalence rate of 35-45%. In this study, we used the Chinese version of the Chronic Liver Disease Questionnaire for NAFLD (CLDQ-NAFLD) to investigate the current health-related quality of life (HRQL) among patients with NAFLD and analyse the influencing factors, which provides a reference for improving the patients' HRQL.

Design: A cross-sectional design.

Germline mutation in Cbl proto-oncogene B is associated with inherited thrombocytopenia and predisposes megakaryocytes to ferroptosis.

Background: Inherited thrombocytopenias (ITs) are a group of heterogeneous diseases characterized by low platelet counts and bleeding diathesis. ITs are primarily caused by mutations in genes involved in megakaryocyte differentiation, maturation and platelet release. To date, ITs encompass 45 disorders with different degrees of variability in the prognosis.

Effect of prednisone plus either adalimumab or cyclosporine on dermatological symptoms in Vogt-Koyanagi-Harada disease: systemic outcomes from a randomized trial.

Background: Vogt-Koyanagi-Harada (VKH) disease causes vitiligo, poliosis, and alopecia.

Objective: To investigate the effect of prednisone plus either adalimumab or cyclosporine-based immunosuppression on VKH dermatological disorders using ancillary data from a VKH eye disease trial.

Methods: Patients with VKH disease treated with individualized prednisone tapering (maximum daily dose, 40 mg; maximum duration, 6 months) were randomized to adjunctive adalimumab (N=54) or cyclosporine (N=56).

A highland-adaptation variant near MCUR1 reduces its transcription and attenuates erythrogenesis in Tibetans.

To identify genomic regions subject to positive selection that might contain genes involved in high-altitude adaptation (HAA), we performed a genome-wide scan by whole-genome sequencing of Tibetan highlanders and Han lowlanders. We revealed a collection of candidate genes located in 30 genomic loci under positive selection. Among them, MCUR1 at 6p23 was a novel pronounced candidate.

Socioeconomic developments drove regime shifts of agriculture-ecology-economy nexus of social-ecological system: Four-decade lessons from southeast China.

Urbanization has been recognized as an effective measure to promote socioeconomic development; however, it leads to cropland and habitat loss and aggravates ecosystem services (ESs), which have not been sufficiently and systematically revealed from the perspective of agriculture-ecology-economy nexus (AEEN). To address these knowledge gaps, this novel study adopted a hotspot of urbanization to examine the response dynamics of ESs and agricultural production to urbanization, as well as their regime shifts and interactions, by employing statistical records, satellite images, and incorporating biophysical model-based ESs into AEEN. In the past four decades, Guangdong has undergone rapid urbanization and associated landscape transformations, represented by cropland and wetland shrinkage and urban expansion, particularly around central city clusters, which have caused ESs degradation and grain productivity reduction.

Polypropylene microplastic exposure modulates multiple metabolic pathways in tobacco leaves, impacting lignin biosynthesis.

The adverse effects of microplastics (MPs) and nanoplastics (NPs) on plant growth have gained significant attention. However, the response of tobacco plants to polypropylene microplastics (PP-MPs) remains poorly understood. To address this, a microcosm experiment was conducted in which tobacco seedlings were exposed to PP-MPs at varying concentrations (100 and 1000 mg/kg) and particle sizes (20 nm and 100 µm) for 48 days in red soil.

Tomato sucrose synthase SUS3 is involved in flower and seed development.

Sucrose is a vital product of photosynthesis and plays important roles in plant growth and development. Sucrose synthase (SUS) is one of the major contributors in sucrose utilization. However, its roles in plant development are still not well understood.

Enhanced tetracycline degradation through electron transfer activated by Bacillus cereus synthesized bio-FeS nanoparticles.

The synthesis of bio-FeS nanoparticles (NPs) was generally using Gram-negative bacteria and mostly in anaerobic systems, thus limiting their application in the degradation of toxic wastewater. In this study, we successfully synthesized bio-FeS NPs for the first time using the resilient Gram-positive bacterium Bacillus cereus, with the objective of investigating the mechanism of promoting electron transfer in the aerobic/anaerobic degradation of tetracycline (TC). The degradation efficiency of TC was increased by 2.

PpSPL1 and PpSPL15 inhibit peach branching by increasing strigolactone synthesis.

PpSPL1 and PpSPL15 inhibit peach branching by directly binding to and upregulating the expression of strigolactone (SL) synthesis gene PpLBO1. Branch number is a crucial agronomic trait that influences tree architecture, directly affecting fruit yield and quality. It remains unknown whether SQUAMOSA PROMOTER BINDING PROTEIN-LIKE (SPL), an important transcription factor in determining plant architecture, is involved in the peach branching process.

Evaluating fusion models for predicting occult lymph node metastasis in tongue squamous cell carcinoma.

Objectives: This study evaluated and compared the effectiveness of various predictive models for forecasting occult lymph node metastasis (LNM) in tongue squamous cell carcinoma (TSCC) patients.

Methods: In this retrospective diagnostic experiment, 268 patients were recruited from three medical centers. Based on the different hospitals from which the patients were recruited, they were divided into a training set, an internal testing set, and two external testing sets, comprising 107, 53, 63, and 45 patients, respectively.

"Pulsed" Chain Transfer Anionic Polymerization: A Green and Cost-Effective Approach for Controlled Polymer Synthesis.

Herein, we report a method that significantly enhances the atom economy of catalysts in living polymerization. By introducing intermittent, switchable chain-transfer reactions during the polymerization process, multiple regenerations of the catalyst are achieved while preserving the "living"/controlled characteristics. The specially designed catalytic system, composed of 1,2-dipyrrolidinoethane/n-butyllithium/n-butylpotassium/toluene, exhibits a chain-transfer rate that is highly sensitive to temperature.

Gasotransmitter-Nanodonor for Spatial Regulation of Anxiety-Like Behavior and Bone Metastasis.

Anxiety is highly prevalent among cancer patients, significantly impacting their prognosis. Current cancer therapies typically lack anxiolytic properties and may even exacerbate anxiety. Here, a gasotransmitter-nanodonors (GND) system is presented that exerts dual anxiolytic and anti-tumor effects via a "tumor-brain axis" strategy.

Dynamic Tumor in Situ Fluid Circulating Tumor DNA Postsurgery Effectively Predicts Recurrence and Clinical Benefits for Glioblastomas.

Background And Objectives: Glioblastoma (GBM) recurrence after surgery remains a significant clinical challenge because of limited early detection methods and effective molecular markers. This study investigates the potential of dynamic tumor in situ fluid circulating tumor DNA (TISF-ctDNA) as a tool for monitoring molecular residual disease and evaluating treatment efficacy in postsurgical patients with GBM.

Methods: In this prospective cohort study, 75 resectable glioma patients were enrolled between October 2019 to June 2023.