Plaque erosion risk and JAK2 V617F variant.

Background And Aims: Clonal haematopoiesis of indeterminate potential (CHIP) can increase the risk of myocardial infarction (MI). Among various CHIP mutations, JAK2 V617F substantially elevated this risk. However, the specific associations between JAK2 V617F and two mechanisms of MI, plaque erosion and plaque rupture, remain unclear.

Thrombin-Responsive and Sequential Targeted Nanoplatform for Synergistic Thrombolysis Therapy.

Traditional thrombolytic therapy is limited by low specificity, uncontrollable bleeding complications, and secondary vascular re-embolism. To address this issue, we developed a thrombin-responsive and sequential targeted nanoplatform (MMSN-UK/TI@pep-Fuco) for efficient thrombolysis based on the attack-defense-protection integrated strategy. Herein, the multilevel mesoporous silica nanoparticle with multiple pore sizes was synthesized and modified with fucoidan (Fuco) using the compound peptide (pep) as a bridge to form multifunctional drug carriers MMSN@pep-Fuco.

Analysis of pregnancy outcomes in patients with unexplained recurrent miscarriage assisted by IVF/ICSI with or without PGT-A.

Purpose: The objective of this study was to evaluate the efficacy of preimplantation genetic testing for aneuploidy (PGT-A) in reducing the incidence of early miscarriage among patients diagnosed with unexplained recurrent spontaneous abortion (URSA).

Methods: This investigation was designed as a retrospective cohort study, examining patients who underwent freeze-thaw embryo transfer (FET) of single blastocysts from January 2018 to August 2023. A total of 675 FET cycles involving patients with URSA were included in the study.

Costunolide Ameliorates the Methylmalonic Acidemia Via the PINK1/Parkin Pathway.

Methylmalonic acidemia (MMA) is a congenital organic acidemia characterized by mitochondrial dysfunction due to the abnormal accumulation of intermediate metabolites, which subsequently leads to brain damage. Currently, there are no specific pharmacological treatments available for MMA in clinical practice. Costunolide (COS) is a sesquiterpenoid compound derived from Radix Aucklandiae, it exhibits a broad spectrum of bioactivities.

The effect of health insurance reimbursement rates on middle-aged and elderly people's hospital choices: evidence from China.

Background: Adjusting the health insurance reimbursement rate is essential to optimize the allocation of medical resources. This paper investigates the effect of health insurance reimbursement rates on middle-aged and elderly people's choice of hospitals in China.

Methods: This study is conducted using the China Health and Retirement Longitudinal Study (CHARLS) database.

Research on the traceability and treatment of nitrate pollution in groundwater: a comprehensive review.

The preservation of groundwater quality is essential for maintaining the integrity of the water ecological cycle. The preservation of groundwater quality is crucial for sustaining the integrity of the water ecological cycle. Nitrate (NO) has emerged as a pervasive contaminant in groundwater, attracting significant research attention due to its extensive distribution and the potential environmental consequences it poses.

Transcriptome analysis of the hypothalamus and testes in Brandt's Vole: new insights into mechanisms of photoperiodic plasticity in postnatal testicular development.

Postnatal gonadal development is regulated by photoperiod via the hypothalamus, especially in seasonal breeding small rodents. However, the precise molecular mechanisms remain unclear. In this study, we conducted a comparative analysis of the transcriptomes of the hypothalamus and testes in 10-week-old male Brandt's voles born under long (LP, 16L:8D) and short photoperiod (SP, 8L:16D) conditions.

Characterization of a G. max × G. soja nested association mapping population and identification of loci controlling seed composition traits from wild soybean.

Wild soybean (Glycine soja Siebold & Zucc.) has valuable genetic diversity for improved disease resistance, stress tolerance, seed protein content and seed sulfur-containing amino acid concentrations. Many studies have reported loci controlling seed composition traits based on cultivated soybean populations, but wild soybean has been largely overlooked.

Uncovering phenolic profiles of different forms in safflower seeds and their antioxidant capacity, and biological activity.

In this study, free, soluble bound (glycosylated, esterified), and insoluble-bound phenolic compounds from safflower seeds were identified and quantified by UPLC-MS/MS. The four phenolic fractions were assessed for their antioxidant capacity and inhibition of α-amylase and tyrosinase. In four phenolic fractions, 55 phenolic compounds, mainly flavonoids (19) and phenolic acids (16), were identified.

MAEST: accurately spatial domain detection in spatial transcriptomics with graph masked autoencoder.

Spatial transcriptomics (ST) technology provides gene expression profiles with spatial context, offering critical insights into cellular interactions and tissue architecture. A core task in ST is spatial domain identification, which involves detecting coherent regions with similar spatial expression patterns. However, existing methods often fail to fully exploit spatial information, leading to limited representational capacity and suboptimal clustering accuracy.

A Comparative Study of 141 Glial Fibrillary Acidic Protein Immunoglobulin G Positive Cases.

Background: Glial fibrillary acidic protein-immunoglobulin G (GFAP-IgG) positivity is associated with autoimmune GFAP astrocytopathy (GFAP-A), but also with other autoimmune encephalitides and viral infections. We attempted to elucidate the characteristics of GFAP-A in relation to other GFAP-IgG-positive encephalitides and constructed a differential diagnosis model.

Methods: 141 GFAP-IgG-positive cases were identified, including 52 astrocytopathy (GFAP-A group), 48 autoimmune encephalitis (AE-G), and 41 viral encephalitis (VE-G).

Notch signaling in cancers: mechanism and potential therapy.

The Notch signaling pathway is an evolutionarily conserved intercellular signaling cascade that regulates a number of cellular processes, including cell development, proliferation, apoptosis, and genome stability. The Notch signaling pathway is pervasive in the human body, affecting tumorigenesis and progression, which is one of the most significant signaling pathways in this regard, influencing various receptors and cellular functions of tumor cells. Aberrant expression or mutation of Notch has been linked to the onset and progression of a variety of malignant tumors.

Efficacy and safety of endoscopic fenestration for treating giant middle cranial fossa arachnoid cysts in pediatrics.

Objective: A middle cranial fossa is a well-recognized location for an intracranial arachnoid cyst in children. Giant middle fossa arachnoid cysts (GMFACs) can compress brain tissue, leading to rupture and potentially developing a subdural hygroma or hematoma. With recent advancements in neuroendoscopic technology, neuroendoscopic treatments have increasingly been used for middle fossa cysts.

Spray-induced gene silencing for crop protection: recent advances and emerging trends.

The RNA-based spray-induced gene silencing (SIGS) technology represents an ecologically sustainable approach to crop protection and pathogen management. Following the recent approval of Ledprona as the first sprayable double-stranded RNA (dsRNA) biopesticide by the EPA at the end of 2023, SIGS has emerged as a focal point in both academic and industrial sectors. This review analyzes recent advances and emerging trends in SIGS.

pH-Activated Nanoplatform Derived from M1 Macrophages' Exosomes for Photodynamic and Ferroptosis Synergistic Therapy to Augment Cancer Immunotherapy.

Combining nanomedicine with immunotherapy offers a promising and potent cancer treatment strategy; however, improving the effectiveness of the antitumor immune response remains challenging. A "cold" tumor microenvironment (TME) is a marked factor affecting the efficacy of immunotherapy. Herein, intracellular-acidity-activatable dynamic nanoparticles (NPs) were designed for precision photodynamic immunotherapy and ferroptosis in cancer.

Sleep disturbance among Chinese survivors of childhood sexual abuse: associations with perceived discrimination and rumination.

Background: Although childhood sexual abuse (CSA) has been widely recognized for its association with sleep disturbance (SD) in adulthood, little is known about its associations with perceived discrimination (PD) and rumination. This study seeks to build upon existing literature by examining the impact of CSA on adult SD within a Chinese survivor sample while also investigating the mediating effects of PD and rumination on this association.

Methods: A total of 1,210 respondents completed the Childhood Sexual Abuse Questionnaire, the Inventory of Depressive Symptomatology Self Report, the Perceived Discrimination Scale, and the Ruminative Response Scale.

A new strategy improving TB diagnosis: stratified urine LAM test based on lymphocyte counts.

Background: Traditional lipoarabinomannan tests have limited sensitivity in HIV-negative individuals. Our aims were to compare chemiluminescence-based LAM (AIMLAM) and other diagnostic modalities in HIV-negative patients and to explore whether lymphocyte counts impact the sensitivity and costs of AIMLAM.

Methods: This is a prospective, cross-sectional, diagnostic accuracy study.

Supercritical CO Activation Enables an Exceptional Methanol Synthesis Activity Over the Industrial Cu/ZnO/AlO Catalyst.

The ternary Cu/ZnO/AlO catalyst is widely used in the industry for renewable methanol synthesis. The tenuous trade-off between the strong metal-support interaction (SMSI)-induced Cu-ZnO interface and the accessible Cu surface strongly affects the activity of the final catalyst. Successes in the control of oxide migration on adsorbate-induced SMSI catalysts have motivated this to develop a supercritical CO activation strategy to synchronously perfect the Cu-O-Zn interface and Cu-Cu surface sites through the manipulation of the adsorbate diffusion kinetics, which involves OCH and "side-on" fixed CO species.

A node-localized transporter TaSPDT is responsible for the distribution of phosphorus to grains in wheat.

Wheat (Triticum aestivum L.) is one of the world's main food crops and the largest phosphorus (P) fertilizer consumer globally. However, the molecular mechanism of P distribution in wheat remains largely unknown.

Acid-Controlled Fabrication of Multicolor Carbon Dots with Switchable Organelle-Targeting Capability for Visualizing Organelle Interactions.

Synchronous regulation of the photoluminescence and physicochemical characteristics of multicolor carbon dots (CDs) can fully realize their application potential in multicomponent imaging. Herein, by utilizing an acid-regulated synthetic strategy, green-emissive and orange-emissive CDs that target lipid droplets (LDs) and mitochondria (Mito) have been developed for fluorescence visualization of LD-Mito interactions. The finding of different molecular fluorophores reveals that the precursor undergoes different reaction pathways in neutral and acidic conditions, which alters the size of sp-conjugated domain and surface properties for the successful regulation of photoluminescence properties and organelle-targeting ability.

Realizing the Ultrafast Recovery of the Monolayer MoS-Based NH Sensor by Gas-Ion-Gate.

Over the past decade, the two-dimensional material MoS has attracted great attention due to its room temperature stability, high surface area-to-volume ratios, abundance of active sites at the edges, and exceptional surface sensitivity to the environment, which are key characteristics for applications in chemical sensing. However, the slow recovery of ammonia (NH) sensors based on MoS materials at room temperature has restricted their further development. This paper presents a novel approach to address this limitation by demonstrating a monolayer MoS-based NH sensor with rapid recovery capabilities, leveraging O generated through gas-ion-gate (GIG) technology.

The predictive role of composite inflammatory ratio parameters in the conscious awareness recovery after severe acute ischemic stroke: a retrospective cohort study.

Background: Inflammatory mechanisms play a significant role in ischemic stroke. Peripheral neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), which are indicators capable of reflecting the magnitude of the inflammatory response, have been research hotspots. However, few research findings evaluate the prediction significance of these biomarkers in the recovery of conscious awareness following severe acute ischemic stroke.

LoG-staging: a rectal cancer staging method with LoG operator based on maximization of mutual information.

Deep learning methods have been migrated to rectal cancer staging as a classification process based on magnetic resonance images (MRIs). Typical approaches suffer from the imperceptible variation of images from different stage. The data augmentation also introduces scale invariance and rotation consistency problems after converting MRIs to 2D visible images.

Preparation, characterization and application of chitosan/thyme essential oil composite film.

In order to prepare a chitosan-based antibacterial film with excellent mechanical properties and study its properties, the tape casting method was used to prepare the composite film from chitosan, glycerin and thyme essential oil. Through single factor test and response surface optimization test, the tensile strength and elongation at break were used as response indicators to prepare the composite film with better mechanical properties, and the physical properties, water vapor permeability, solubility and bacteriostasis of the composite film were measured, and the characterization of the microstructure of the composite films. The results showed that the optimized composite film ratio was 1.