Intermetallic PtSn Nanosheets with p-d Orbital Hybridization for Selective Hydroxylamine Electrosynthesis.

The electrocatalytic nitrate reduction to hydroxylamine (NHOH) is a challenging catalytic process that has gained significant attention. However, its performance is hindered by the low selectivity of the electrocatalysts. Here, intermetallic PtSn nanosheets with p-d orbital hybridization have been synthesized, which significantly enhances the performance of electrocatalytic nitrate reduction to NHOH.

TMSOTf/TfOH-Promoted [4 + 2] Annulation of Ynamides with 2-Aminoarylnitriles To Construct 2,4-Diaminoquinolines.

An effective strategy to synthesize 2,4-diaminoquinoline compounds has been efficaciously developed via a TMSOTf/TfOH-promoted [4 + 2] annulation of ynamides with 2-aminoarylnitriles. Compared with the reported transition-metal catalysts, this metal-free promotion system presented a remarkable advancement, enabling the facile and regiospecific assembly of 2,4-diaminoquinoline frameworks with wide functional group compatibility and moderate to excellent yields.

ImmunoPET Imaging of Trop2 Expression in Bladder Cancer Using [Cu]Cu-NOTA-Trodelvy.

Trop2 exhibits significantly elevated expression in numerous solid malignancies, playing a crucial role in tumor advancement, whereas its presence in healthy tissues is minimal. In this study, we investigated Trop2 expression in bladder cancer models using [Cu]Cu-NOTA-Trodelvy for immunoPET imaging. In HT-1376 models, [Cu]Cu-NOTA-Trodelvy effectively visualized tumor as early as 12 h p.

CPCGI Alleviates Neural Damage by Modulating Microglial Pyroptosis After Traumatic Brain Injury.

Background: Traumatic brain injury (TBI) is a major global cause of mortality and long-term disability, with limited therapeutic options. Microglial pyroptosis, a form of programmed cell death associated with inflammation, has been implicated in exacerbating neuroinflammation and secondary injury following TBI. Compound porcine cerebroside ganglioside injection (CPCGI) has shown anti-inflammatory and antioxidant properties, but its effects on pyroptosis remain unexplored.

Progress on clinical and mechanism researches of acupuncture therapy for asthma.

Asthma is a chronic lung disease that occurs repeatedly and is hardly cured. Clinical studies have shown that acupuncture can effectively relieve asthma-related symptoms and is an ideal measure to treat asthma. The paper reviews the clinical and mechanism researches of acupuncture for asthma reported in China and other countries in recent 5 years, so as to provide the relevant evidences for the further study on asthma.

Clinical observation on treatment of patients with kidney- deficiency type ankylosing spondylitis by using Bushen Tongdu external treatment.

Objectives: To observe and evaluate the effectiveness and safety of Bushen Tongdu (reinforcing the kidney- and regulating the Governor Vessel) external treatment for patients with kidney- deficiency type ankylosing spondylitis (AS).

Methods: Patients with Kidney- deficiency type AS were randomly divided into an observation group(36 cases, 4 cases dropped out) and a control group(36 cases, 3 cases dropped out). The observation group were received the Bushen Tongdu external treatment which was a combination of Ren Du Zhou-Tian moxibustion and acupoint embedding therapy, i.

Curcumin delivery based on bovine bone protein hydrolysate-flaxseed gum emulsion carrier: a strategy for stability enhancement and bioaccessibility improvement.

Background: Curcumin is a natural polyphenolic compound that exhibits various biological activities. However, its low solubility in water and instability significantly limit its potential application in the food industry. Therefore, appropriate encapsulation systems are required to address these limitations.

Unveiling brain response mechanisms of citrus flavor perception: An EEG-based study on sensory and cognitive responses.

Citrus flavors are globally popular in food industry, yet research on the perceptual preferences of various citrus flavors is limited. Based on the subjective sensory evaluation, this study introduces a novel sensory analysis approach, using electroencephalography (EEG), to objectively measure the sensory and cognitive responses to nine citrus flavors, including d-limonene, concentrated (H-) and original essential oils of sweet orange (SEO), bergamot EO (BEO), lemon EO (LEO), and grapefruit EO (GEO). Results revealed that δ (0.

Research progress of photoelectrochemical sensors in food detection.

Food is the basic of the people, security is the basic of the food. As the quality of life improves, food safety has emerged as a global concern, making the development of simple, rapid, and efficient food safety detection methods critically important. Photoelectrochemical (PEC) sensors are a novel class of sensors developed in recent years that integrate photoelectric technology with biosensing.

The stability and in vitro digestion of resveratrol-loaded emulsion stabilized with peanut protein hydrolysate and dextran conjugate.

In this study, resveratrol emulsion was constructed using peanut protein isolate hydrolysate (HPPI) and dextran (Dex) conjugate (HPPI-Dex) as carriers. The interfacial properties of HPPI-Dex and the stability and digestion characteristics of the emulsion were investigated. The results showed that HPPI-Dex had lower interfacial tension, and the encapsulation rate of resveratrol in HPPI-Dex emulsion reached 97.

Effects of Lactobacillus curvatus SQ-425 and Staphylococcus simulans 65-4 as starter cultures on sensory characteristics, microbial communities and metabolites in fermented sausage.

Mixed starting cultures have been reported to perform better than commonly used single Lactic acid bacteria in meat fermentation. Lactobacillus curvatus SQ-425 and Staphylococcus simulans 65-4 were screened from 67 sausages collected from southwest regions in China to investigate the effects of single and combined inoculation (SF and CMF) on sausages quality, while natural fermentation (NF) was used as a control group. Inoculation of mixed cultures resulted in a continuous decrease in pH during fermentation, an increase in redness values of sausages and the highest sensory score.

Targeting the Contact-Kinin System: A Cyclopeptide with Anti-Thromboinflammatory Properties Against Stroke.

The contact-kinin system plays a central role in the thromboinflammatory pathology of ischemic stroke. Modulating this pathway represents a promising strategy for the prevention and treatment of ischemic stroke. Based on our recent findings demonstrating that the short peptide SD6 (SLGASD), derived from a specific influenza-related immunoglobulin heavy chain junction region sequence, exhibits anti-coagulant properties, we designed a cyclized version, cycloSD6, and evaluated its anti-ischemic stroke potential.

Role and mechanism of IL-33 in bacteria infection related gastric cancer continuum: From inflammation to tumor progression.

Gastric cancer, a globally prevalent malignant tumor, is characterized by low early diagnosis rate, high metastasis rate, and poor prognosis, particularly in East Asia, Eastern Europe, and South America. Helicobacter pylori (H. pylori) is recognized as the primary risk factor for gastric cancer.

Hippocampal Sclerosis: A Review on Current Research Status and Its Mechanisms.

Hippocampal sclerosis (HS) is a pathological condition characterized by significant loss of hippocampal neurons and gliosis. This condition represents the most common neuropathological change observed in patients with temporal lobe epilepsy (TLE) and is also found in aging individuals. TLE related to HS is the most prevalent type of drug-resistant epilepsy in adults, and its underlying mechanisms are not yet fully understood.

Catalase-induced changes in rheological properties and structure of wheat gluten proteins.

This study investigates the impact of catalase (CAT) on the rheological properties of wheat gluten by analyzing CAT-induced structural changes in gluten proteins to uncover the mechanisms behind these modifications. The results showed that CAT significantly enhanced the storage modulus (G') and loss modulus (G″) of gluten while reducing creep strain and recovery strain. The most pronounced effects were observed with the addition of 250 U/g CAT for 30 min.

Material basis and mechanism of Ephedra sinica in interfering with wind-chill cold.

Ephedra sinica has a long history in medicine, i.e., as the first medicinal plant for treating wind-chill colds.

Efficacy and Safety of 611 in Chinese Adults with Moderate-to-Severe Atopic Dermatitis: Results from a Phase II Trial.

Introduction: Atopic dermatitis (AD) is a chronic inflammatory skin disease. 611, a humanized monoclonal antibody, selectively targets the interleukin (IL)-4 receptor alpha, thereby inhibiting the signaling of both interleukin (IL)-4 and IL-13. This phase 2 study aimed to evaluate the efficacy and safety of 611 in Chinese adults with moderate-to-severe AD.

CPHNet: a novel pipeline for anti-HAPE drug screening via deep learning-based Cell Painting scoring.

Background: High altitude pulmonary edema (HAPE) poses a significant medical challenge to individuals ascending rapidly to high altitudes. Hypoxia-induced cellular morphological changes in the alveolar-capillary barrier such as mitochondrial structural alterations and cytoskeletal reorganization, play a crucial role in the pathogenesis of HAPE. These morphological changes are critical in understanding the cellular response to hypoxia and represent potential therapeutic targets.

A physical activity counseling intervention to promote health among pregnant women: a study protocol of randomized clinical trial.

Background: Pregnancy may result in gestational diabetes mellitus (GDM), discomfort, pregnancy-related musculoskeletal pain, sleep disturbances, and decreased quality of life in pregnant women. Physical activity during pregnancy can lower the odds ratio of developing GDM and offer numerous health benefits for mothers and infants. However, the prevalence of physical inactivity among pregnant women worldwide is high.

Maternal behavior promotes resilience to adolescent stress in mice through a microglia-neuron axis.

Early life experience modulates resilience to stress in later life. Previous research implicated maternal care as a key mediator of behavioral responses to the adversity in adolescence, but details of molecular mechanisms remain elusive. Here, we show social stress activates transcription factor C/EBPβ in mPFC neurons of adolescent mice, which transcriptionally upregulates Dnm1l and promotes mitochondrial dysfunction, thereby conferring stress susceptibility in adolescent mice.

Melatonin affects trophoblast epithelial-to-mesenchymal transition and oxidative damage resistance by modulating GDF15 expression to promote embryo implantation.

Melatonin is widely observed in the female reproductive system and regulates trophoblast cell functions, but its effects on embryo implantation and underlying mechanisms are not well understood. By constructing an in vitro embryo culture model, we found that melatonin enhances migration and implantation in human and mouse trophoblast cells. It also significantly promoted HTR-8/SVneo cell proliferation, inhibited apoptosis, enhanced migration, and mitigated oxidative damage.

Transcription factor ELF-1 protects against colitis by maintaining intestinal epithelium homeostasis.

Inflammatory bowel disease (IBD) is a chronic, relapsing, and remitting disease characterized by chronic inflammation in the gastrointestinal tract. The exact etiology and pathogenesis of IBD remain elusive. Although ELF-1 has been known to be highly expressed in epithelial cells for past twenty years, little is known about its function in epithelial cells and epithelial-related IBD.

Ivonescimab versus pembrolizumab for PD-L1-positive non-small cell lung cancer (HARMONi-2): a randomised, double-blind, phase 3 study in China.

Background: Ivonescimab is a bispecific antibody against programmed cell death protein 1 and vascular endothelial growth factor, yielding promising clinical outcomes for patients with advanced non-small cell lung cancer in early-phase studies. We compared the efficacy and safety of ivonescimab with pembrolizumab in patients with programmed cell death ligand-1 (PD-L1)-positive advanced non-small cell lung cancer.

Methods: HARMONi-2 is a randomised, double-blind, phase 3 trial across 55 hospitals in China.

Clinical Outcome of UCBT for Children with CAEBV: A Retrospective Analysis of a Single Center.

Background: Chronic active Epstein-Barr virus (CAEBV) infection is a severe, life-threatening condition characterized by persistent Epstein-Barr virus (EBV) infection and the clonal expansion of infected T or NK cells, leading to systemic inflammation, organ damage, and complications such as hemophagocytic lymphohistiocytosis and lymphoma. Allogeneic hematopoietic stem cell transplantation (HSCT) is the only effective treatment for eradicating EBV-infected cells; however, donor availability is limited. Umbilical cord blood stem cell transplantation (UCBT) is a promising alternative owing to its rapid availability and lower complication risk.

Classifying schizophrenia using functional MRI and investigating underlying functional phenomena.

Background: Existing studies have revealed functional abnormalities in certain brain regions of patients with schizophrenia (SZ), but the relationships between these abnormalities and their impact on disease progression remain unclear.

Methods: Fifty-six patients with SZ and 56 healthy controls were included. Based on resting-state functional magnetic resonance imaging, we analyzed fractional amplitude of low-frequency fluctuations (fALFF), regional homogeneity (ReHo), and degree centrality (DC).